High affinity immunoglobulin gamma Fc receptor I

NameHigh affinity immunoglobulin gamma Fc receptor I
Synonyms
  • Fc-gamma RI
  • Fc-gamma RIA
  • FCG1
  • FcgammaRIa
  • FCGR1
  • FcRI
  • IGFR1
  • IgG Fc receptor I
Gene NameFCGR1A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001416|High affinity immunoglobulin gamma Fc receptor I
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG
TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL
ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG
ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN
TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG
IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ
LQEGVHRKEPQGAT
Number of residues374
Molecular Weight42631.525
Theoretical pI8.08
GO Classification
Functions
  • receptor signaling protein activity
Processes
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • innate immune response
  • regulation of immune response
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • phagocytosis, engulfment
  • intracellular signal transduction
  • cytokine-mediated signaling pathway
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • antigen processing and presentation of peptide antigen via MHC class I
  • interferon-gamma-mediated signaling pathway
  • signal transduction
  • immune response
Components
  • plasma membrane
  • integral component of membrane
  • early endosome membrane
  • clathrin-coated endocytic vesicle membrane
General FunctionReceptor signaling protein activity
Specific FunctionHigh affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Pfam Domain Function
Transmembrane Regions293-313
GenBank Protein ID31332
UniProtKB IDP12314
UniProtKB Entry NameFCGR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016183|High affinity immunoglobulin gamma Fc receptor I (FCGR1A)
ATGTGGTTCTTGACAACTCTGCTCCTTTGGGTTCCAGTTGATGGGCAAGTGGACACCACA
AAGGCAGTGATCACTTTGCAGCCTCCATGGGTCAGCGTGTTCCAAGAGGAAACCGTAACC
TTGCACTGTGAGGTGCTCCATCTGCCTGGGAGCAGCTCTACACAGTGGTTTCTCAATGGC
ACAGCCACTCAGACCTCGACCCCCAGCTACAGAATCACCTCTGCCAGTGTCAATGACAGT
GGTGAATACAGGTGCCAGAGAGGTCTCTCAGGGCGAAGTGACCCCATACAGCTGGAAATC
CACAGAGGCTGGCTACTACTGCAGGTCTCCAGCAGAGTCTTCACGGAAGGAGAACCTCTG
GCCTTGAGGTGTCATGCGTGGAAGGATAAGCTGGTGTACAATGTGCTTTACTATCGAAAT
GGCAAAGCCTTTAAGTTTTTCCACTGGAATTCTAACCTCACCATTCTGAAAACCAACATA
AGTCACAATGGCACCTACCATTGCTCAGGCATGGGAAAGCATCGCTACACATCAGCAGGA
ATATCTGTCACTGTGAAAGAGCTATTTCCAGCTCCAGTGCTGAATGCATCTGTGACATCC
CCACTCCTGGAGGGGAATCTGGTCACCCTGAGCTGTGAAACAAAGTTGCTCTTGCAGAGG
CCTGGTTTGCAGCTTTACTTCTCCTTCTACATGGGCAGCAAGACCCTGCGAGGCAGGAAC
ACATCCTCTGAATACCAAATACTAACTGCTAGAAGAGAAGACTCTGGGTTATACTGGTGC
GAGGCTGCCACAGAGGATGGAAATGTCCTTAAGCGCAGCCCTGAGTTGGAGCTTCAAGTG
CTTGGCCTCCAGTTACCAACTCCTGTCTGGTTTCATGTCCTTTTCTATCTGGCAGTGGGA
ATAATGTTTTTAGTGAACACTGTTCTCTGGGTGACAATACGTAAAGAACTGAAAAGAAAG
AAAAAGTGGGATTTAGAAATCTCTTTGGATTCTGGTCATGAGAAGAAGGTAATTTCCAGC
CTTCAAGAAGACAGACATTTAGAAGAAGAGCTGAAATGTCAGGAACAAAAAGAAGAACAG
CTGCAGGAAGGGGTGCACCGGAAGGAGCCCCAGGGGGCCACGTAG
GenBank Gene IDX14356
GeneCard IDNot Available
GenAtlas IDFCGR1A
HGNC IDHGNC:3613
Chromosome Location1
Locus1q21.2-q21.3
References
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