NameADP/ATP translocase 1
Synonyms
  • Adenine nucleotide translocator 1
  • ADP,ATP carrier protein 1
  • ADP,ATP carrier protein, heart/skeletal muscle isoform T1
  • ANT 1
  • ANT1
  • Solute carrier family 25 member 4
Gene NameSLC25A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010417|ADP/ATP translocase 1
MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVR
IPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVS
VQGIIIYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMM
QSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV
Number of residues298
Molecular Weight33064.265
Theoretical pI10.27
GO Classification
Functions
  • adenine transmembrane transporter activity
Processes
  • small molecule metabolic process
  • energy reserve metabolic process
  • regulation of insulin secretion
  • apoptotic mitochondrial changes
  • viral process
  • adenine transport
  • mitochondrial genome maintenance
  • negative regulation of necroptotic process
  • generation of precursor metabolites and energy
  • transport
Components
  • nucleus
  • mitochondrial inner membrane
  • myelin sheath
  • integral component of plasma membrane
  • mitochondrion
General FunctionAdenine transmembrane transporter activity
Specific FunctionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
Pfam Domain Function
Transmembrane Regions5-39 75-100 109-143 176-202 207-241 273-298
GenBank Protein ID339920
UniProtKB IDP12235
UniProtKB Entry NameADT1_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010418|ADP/ATP translocase 1 (SLC25A4)
ATGGGTGATCACGCTTGGAGCTTCCTAAAGGACTTCCTGGCCGGGGGCGTCGCCGCTGCC
GTCTCCAAGACCGCGGTCGCCCCCATCGAGAGGGTCAAACTGCTGCTGCAGGTCCAGCAT
GCCAGCAAACAGATCAGTGCTGAGAAGCAGTACAAAGGGATCATTGATTGTGTGGTGAGA
ATCCCTAAGGAGCAGGGCTTCCTCTCCTTCTGGAGGGGTAACCTGGCCAACGTGATCCGT
TACTTCCCCACCCAAGCTCTCAACTTCGCCTTCAAGGACAAGTACAAGCAGCTCTTCTTA
GGGGGTGTGGATCGGCATAAGCAGTTCTGGCGCTACTTTGCTGGTAACCTGGCGTCCGGT
GGGGCCGCTGGGGCCACCTCCCTTTGCTTTGTCTACCCGCTGGACTTTGCTAGGACCAGG
TTGGCTGCTGATGTGGGCAAGGGCGCCGCCCAGCGTGAGTTCCATGGTCTGGGCGACTGT
ATCATCAAGATCTTCAAGTCTGATGGCCTGAGGGGGCTCTACCAGGGTTTCAACGTCTCT
GTCCAAGGCATCATTATCTATAGAGCTGCCTACTTCGGAGTCTATGATACTGCCAAGGGG
ATGCTGCCTGACCCCAAGAACGTGCACATTTTTGTGAGCTGGATGATTGCCCAGAGTGTG
ACGGCAGTCGCAGGGCTGGTGTCCTACCCCTTTGACACTGTTCGTCGTAGAATGATGATG
CAGTCCGGCCGGAAAGGGGCCGATATTATGTACACGGGGACAGTTGACTGCTGGAGGAAG
ATTGCAAAAGACGAAGGAGCCAAGGCCTTCTTCAAAGGTGCCTGGTCCAATGTGCTGAGA
GGCATGGGCGGTGCTTTTGTATTGGTGTTGTATGATGAGATCAAAAAATATGTCTAA
GenBank Gene IDJ02966
GeneCard IDNot Available
GenAtlas IDSLC25A4
HGNC IDHGNC:10990
Chromosome Location4
Locus4q35
References
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  2. Cozens AL, Runswick MJ, Walker JE: DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989 Mar 20;206(2):261-80. 2541251
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