NameFatty acid-binding protein, intestinal
Synonyms
  • FABPI
  • Fatty acid-binding protein 2
  • I-FABP
  • Intestinal-type fatty acid-binding protein
Gene NameFABP2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012494|Fatty acid-binding protein, intestinal
MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQEGNKFTVKESSAFRNIE
VVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNELNTVREIIGDELVQTYVY
EGVEAKRIFKKD
Number of residues132
Molecular Weight15207.165
Theoretical pI7.52
GO Classification
Functions
  • transporter activity
  • fatty acid binding
Processes
  • digestion
  • small molecule metabolic process
  • triglyceride catabolic process
Components
  • cytosol
General FunctionTransporter activity
Specific FunctionFABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID46854681
UniProtKB IDP12104
UniProtKB Entry NameFABPI_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012495|Fatty acid-binding protein, intestinal (FABP2)
ATGGCGTTTGACAGCACTTGGAAGGTAGACCGGAGTGAAAACTATGACAAGTTCATGGAA
AAAATGGGTGTTAATATAGTGAAAAGGAAGCTTGCAGCTCATGACAATTTGAAGCTGACA
ATTACACAAGAAGGAAATAAATTCACAGTCAAAGAATCAAGCACTTTTCGAAACATTGAA
GTTGTTTTTGAACTTGGTGTCACCTTTAATTACAATCTAGCAGACGGAACTGAACTCAGG
GGGACCTGGAGCCTTGAGGGAAATAAACTTATTGGAAAATTCAAACGGACAGACAATGGA
AACGAACTGAATACTGTCCGAGAAATTATAGGTGATGAACTAGTCCAGACTTATGTATAT
GAAGGAGTAGAAGCCAAAAGGATCTTTAAAAAGGATTGA
GenBank Gene IDBC069466
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3556
Chromosome Location4
Locus4q28-q31
References
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  4. Pelsers MM, Namiot Z, Kisielewski W, Namiot A, Januszkiewicz M, Hermens WT, Glatz JF: Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. Clin Biochem. 2003 Oct;36(7):529-35. 14563446
  5. Darimont C, Gradoux N, de Pover A: Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells. Am J Physiol. 1999 Mar;276(3 Pt 1):G606-12. 10070036
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