Guanine nucleotide-binding protein G(t) subunit alpha-1

NameGuanine nucleotide-binding protein G(t) subunit alpha-1
Synonyms
  • GNATR
  • Transducin alpha-1 chain
Gene NameGNAT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020727|Guanine nucleotide-binding protein G(t) subunit alpha-1
MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLE
ECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMS
DIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGI
IETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMH
ESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIK
VQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
Number of residues350
Molecular Weight40040.415
Theoretical pI5.32
GO Classification
Functions
  • G-protein beta/gamma-subunit complex binding
  • signal transducer activity
  • G-protein coupled receptor binding
  • GTP binding
  • GTPase activity
  • metal ion binding
  • GDP binding
  • acyl binding
  • protein kinase binding
Processes
  • response to light intensity
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • retina development in camera-type eye
  • sensory perception of umami taste
  • signal transduction
  • positive regulation of cyclic-nucleotide phosphodiesterase activity
  • cellular response to electrical stimulus
  • detection of chemical stimulus involved in sensory perception of bitter taste
  • negative regulation of cyclic-nucleotide phosphodiesterase activity
  • detection of light stimulus involved in visual perception
  • response to light stimulus
  • regulation of rhodopsin mediated signaling pathway
  • visual perception
  • rhodopsin mediated signaling pathway
  • eye photoreceptor cell development
  • cell proliferation
  • phototransduction, visible light
Components
  • neuronal cell body
  • photoreceptor connecting cilium
  • membrane
  • plasma membrane
  • photoreceptor inner segment
  • heterotrimeric G-protein complex
  • cytosol
  • photoreceptor disc membrane
  • photoreceptor outer segment membrane
  • apical plasma membrane
  • photoreceptor outer segment
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31865
UniProtKB IDP11488
UniProtKB Entry NameGNAT1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0020728|Guanine nucleotide-binding protein G(t) subunit alpha-1 (GNAT1)
ATGGGGGCTGGGGCCAGTGCTGAGGAGAAGCACTCCAGGGAGCTGGAAAAGAAGCTGAAA
GAGGACGCTGAGAAGGATGCTCGAACCGTGAAGCTGCTGCTTCTGGGTGCCGGTGAGTCC
GGGAAGAGCACCATCGTCAAGCAGATGAAGATTATCCACCAGGACGGGTACTCGCTGGAA
GAGTGCCTCGAGTTTATCGCCATCATCTACGGCAACACGTTGCAGTCCATCCTGGCCATC
GTACGCGCCATGACCACACTCAACATCCAGTACGGAGACTCTGCACGCCAGGACGACGCC
CGGAAGCTGATGCACATGGCAGACACTATCGAGGAGGGCACGATGCCCAAGGAGATGTCG
GACATCATCCAGCGGCTGTGGAAGGACTCCGGTATCCAGGCCTGTTTTGAGCGCGCCTCG
GAGTACCAGCTCAACGACTCGGCGGGCTACTACCTCTCCGACCTGGAGCGCCTGGTAACC
CCGGGCTACGTGCCCACCGAGCAGGACGTGCTGCGCTCGCGAGTCAAGACCACTGGCATC
ATCGAGACGCAGTTCTCCTTCAAGGATCTCAACTTCCGGATGTTCGATGTGGGCGGGCAG
CGCTCGGAGCGCAAGAAGTGGATCCACTGCTTCGAGGGCGTGACCTGCATCATCTTCATC
GCGGCGCTGAGCGCCTACGACATGGTGCTAGTGGAGGACGACGAAGTGAACCGCATGCAC
GAGAGCCTGCACCTGTTCAACAGCATCTGCAACCACCGCTACTTCGCCACGACGTCCATC
GTGCTCTTCCTTAACAAGAAGGACGTCTTCTTCGAGAAGATCAAGAAGGCGCACCTCAGC
ATCTGTTTCCCGGACTACGATGGACCCAACACCTACGAGGACGCCGGCAACTACATCAAG
GTGCAGTTCCTCGAGCTCAACATGCGGCGCGACGTGAAGGAGATCTATTCCCACATGACG
TGCGCCACCGACACGCAGAACGTCAAATTTGTCTTCGACGCTGTCACCGACATCATCATC
AAGGAGAACCTCAAAGACTGTGGCCTCTTCTGA
GenBank Gene IDX15088
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4393
Chromosome Location3
Locus3p21
References
  1. Fong SL: Characterization of the human rod transducin alpha-subunit gene. Nucleic Acids Res. 1992 Jun 11;20(11):2865-70. 1614872
  2. Lerea CL, Bunt-Milam AH, Hurley JB: Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. Neuron. 1989 Sep;3(3):367-76. 2534964
  3. Van Dop C, Medynski DC, Apone LM: Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye. Nucleic Acids Res. 1989 Jun 26;17(12):4887. 2748346
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  6. Bell MW, Desai N, Guo XX, Ghalayini AJ: Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments. J Neurochem. 2000 Nov;75(5):2006-19. 11032890
  7. Szabo V, Kreienkamp HJ, Rosenberg T, Gal A: p.Gln200Glu, a putative constitutively active mutant of rod alpha-transducin (GNAT1) in autosomal dominant congenital stationary night blindness. Hum Mutat. 2007 Jul;28(7):741-2. 17584859
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  9. Dryja TP, Hahn LB, Reboul T, Arnaud B: Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. Nat Genet. 1996 Jul;13(3):358-60. 8673138
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