Glucose-6-phosphate 1-dehydrogenase

NameGlucose-6-phosphate 1-dehydrogenase
Synonyms
  • 1.1.1.49
  • G6PD
Gene NameG6PD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002167|Glucose-6-phosphate 1-dehydrogenase
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
Number of residues515
Molecular Weight59256.31
Theoretical pI6.84
GO Classification
Functions
  • glucose-6-phosphate dehydrogenase activity
  • glucose binding
  • protein homodimerization activity
  • identical protein binding
  • NADP binding
Processes
  • oxidation-reduction process
  • negative regulation of protein glutathionylation
  • lipid metabolic process
  • pentose-phosphate shunt
  • pentose biosynthetic process
  • response to food
  • pentose-phosphate shunt, oxidative branch
  • ribose phosphate biosynthetic process
  • regulation of neuron apoptotic process
  • gene expression
  • response to ethanol
  • small molecule metabolic process
  • transcription initiation from RNA polymerase II promoter
  • NADPH regeneration
  • glutathione metabolic process
  • substantia nigra development
  • carbohydrate metabolic process
  • response to organic cyclic compound
  • glucose metabolic process
  • cellular response to oxidative stress
  • NADP metabolic process
  • cholesterol biosynthetic process
  • erythrocyte maturation
  • glucose 6-phosphate metabolic process
Components
  • nucleus
  • cytosol
  • extracellular exosome
  • microtubule organizing center
  • centrosome
  • cytoplasmic side of plasma membrane
  • cytoplasm
  • intracellular membrane-bounded organelle
  • membrane
General FunctionProtein homodimerization activity
Specific FunctionCatalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31543
UniProtKB IDP11413
UniProtKB Entry NameG6PD_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016308|Glucose-6-phosphate 1-dehydrogenase (G6PD)
ATGGGCCGGCGGGGCTCAGCCCCCGGAAACGGTCGTACACTTCGGGGCTGCGAGCGCGGA
GGGCGACGACGACGAAGCGCAGACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACC
CAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGGGCGATGCCTTCCATCAGTCGGAT
ACACACATATTCATCATCATGGGTGCATCGGGTGACCTGGCCAAGAAGAAGATCTACCCC
ACCATCTGGTGGCTGTTCCGGGATGGCCTTCTGCCCGAAAACACCTTCATCGTGGGCTAT
GCCCGTTCCCGCCTCACAGTGGCTGACATCCGCAAACAGAGTGAGCCCTTCTTCAAGGCC
ACCCCAGAGGAGAAGCTCAAGCTGGAGGACTTCTTTGCCCGCAACTCCTATGTGGCTGGC
CAGTACGATGATGCAGCCTCCTACCAGCGCCTCAACAGCCACATGAATGCCCTCCACCTG
GGGTCACAGGCCAACCGCCTCTTCTACCTGGCCTTGCCCCCGACCGTCTACGAGGCCGTC
ACCAAGAACATTCACGAGTCCTGCATGAGCCAGATAGGCTGGAACCGCATCATCGTGGAG
AAGCCCTTCGGGAGGGACCTGCAGAGCTCTGACCGGCTGTCCAACCACATCTCCTCCCTG
TTCCGTGAGGACCAGATCTACCGCATCGACCACTACCTGGGCAAGGAGATGGTGCAGAAC
CTCATGGTGCTGAGATTTGCCAACAGGATCTTCGGCCCCATCTGGAACCGGGACAACATC
GCCTGCGTTATCCTCACCTTCAAGGAGCCCTTTGGCACTGAGGGTCGCGGGGGCTATTTC
GATGAATTTGGGATCATCCGGGACGTGATGCAGAACCACCTACTGCAGATGCTGTGTCTG
GTGGCCATGGAGAAGCCCGCCTCCACCAACTCAGATGACGTCCGTGATGAGAAGGTCAAG
GTGTTGAAATGCATCTCAGAGGTGCAGGCCAACAATGTGGTCCTGGGCCAGTACGTGGGG
AACCCCGATGGAGAGGGCGAGGCCACCAAAGGGTACCTGGACGACCCCACGGTGCCCCGC
GGGTCCACCACCGCCACTTTTGCAGCCGTCGTCCTCTATGTGGAGAATGAGAGGTGGGAT
GGGGTGCCCTTCATCCTGCGCTGCGGCAAGGCCCTGAACGAGCGCAAGGCCGAGGTGAGG
CTGCAGTTCCATGATGTGGCCGGCGACATCTTCCACCAGCAGTGCAAGCGCAACGAGCTG
GTGATCCGCGTGCAGCCCAACGAGGCCGTGTACACCAAGATGATGACCAAGAAGCCGGGC
ATGTTCTTCAACCCCGAGGAGTCGGAGCTGGACCTGACCTACGGCAACAGATACAAGAAC
GTGAAGCTCCCTGACGCCTATGAGCGCCTCATCCTGGACGTCTTCTGCGGGAGCCAGATG
CACTTCGTGCGCAGCGACGAGCTCCGTGAGGCCTGGCGTATTTTCACCCCACTGCTGCAC
CAGATTGAGCTGGAGAAGCCCAAGCCCATCCCCTATATTTATGGCAGCCGAGGCCCCACG
GAGGCAGACGAGCTGATGAAGAGAGTGGGTTTCCAGTATGAGGGCACCTACAAGTGGGTG
AACCCCCACAAGCTCTGA
GenBank Gene IDX03674
GeneCard IDNot Available
GenAtlas IDG6PD
HGNC IDHGNC:4057
Chromosome LocationX
LocusXq28
References
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