NameSolute carrier family 2, facilitated glucose transporter member 3
Synonyms
  • Glucose transporter type 3, brain
  • GLUT-3
  • GLUT3
Gene NameSLC2A3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017515|Solute carrier family 2, facilitated glucose transporter member 3
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLT
SLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEML
ILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGS
EELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQ
EMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG
VQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYN
GMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLF
PSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGV
MEMNSIEPAKETTTNV
Number of residues496
Molecular Weight53923.785
Theoretical pINot Available
GO Classification
Functions
  • glucose binding
  • glucose transmembrane transporter activity
Processes
  • small molecule metabolic process
  • carbohydrate metabolic process
  • transmembrane transport
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • L-ascorbic acid metabolic process
  • glucose transport
  • hexose transport
  • glucose transmembrane transport
Components
  • extracellular exosome
  • integral component of plasma membrane
  • plasma membrane
  • integral component of membrane
General FunctionGlucose transmembrane transporter activity
Specific FunctionFacilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).
Pfam Domain Function
Transmembrane Regions11-32 65-85 91-111 119-142 154-174 184-204 270-290 305-325 332-352 364-389 400-420 430-450
GenBank Protein IDNot Available
UniProtKB IDP11169
UniProtKB Entry NameGTR3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017516|Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
ATGGGGACACAGAAGGTCACCCCAGCTCTGATATTTGCCATCACAGTTGCTACAATCGGC
TCTTTCCAATTTGGCTACAACACTGGGGTCATCAATGCTCCTGAGAAGATCATAAAGGAA
TTTATCAATAAAACTTTGACGGACAAGGGAAATGCCCCACCCTCTGAGGTGCTGCTCACG
TCTCTCTGGTCCTTGTCTGTGGCCATATTTTCCGTCGGGGGTATGATCGGCTCCTTTTCC
GTCGGACTCTTCGTCAACCGCTTTGGCAGGCGCAATTCAATGCTGATTGTCAACCTGTTG
GCTGTCACTGGTGGCTGCTTTATGGGACTGTGTAAAGTAGCTAAGTCGGTTGAAATGCTG
ATCCTGGGTCGCTTGGTTATTGGCCTCTTCTGCGGACTCTGCACAGGTTTTGTGCCCATG
TACATTGGAGAGATCTCGCCTACTGCCCTGCGGGGTGCCTTTGGCACTCTCAACCAGCTG
GGCATCGTTGTTGGAATTCTGGTGGCCCAGATCTTTGGTCTGGAATTCATCCTTGGGTCT
GAAGAGCTATGGCCGCTGCTACTGGGTTTTACCATCCTTCCTGCTATCCTACAAAGTGCA
GCCCTTCCATTTTGCCCTGAAAGTCCCAGATTTTTGCTCATTAACAGAAAAGAAGAGGAG
AATGCTAAGCAGATCCTCCAGCGGTTGTGGGGCACCCAGGATGTATCCCAAGACATCCAG
GAGATGAAAGATGAGAGTGCAAGGATGTCACAAGAAAAGCAAGTCACCGTGCTAGAGCTC
TTTAGAGTGTCCAGCTACCGACAGCCCATCATCATTTCCATTGTGCTCCAGCTCTCTCAG
CAGCTCTCTGGGATCAATGCTGTGTTCTATTACTCAACAGGAATCTTCAAGGATGCAGGT
GTTCAAGAGCCCATCTATGCCACCATCGGCGCGGGTGTGGTTAATACTATCTTCACTGTA
GTTTCTCTATTTCTGGTGGAAAGGGCAGGAAGAAGGACTCTGCATATGATAGGCCTTGGA
GGGATGGCTTTTTGTTCCACGCTCATGACTGTTTCTTTGTTATTAAAGGATAACTATAAT
GGGATGAGCTTTGTCTGTATTGGGGCTATCTTGGTCTTTGTAGCCTTCTTTGAAATTGGA
CCAGGCCCCATTCCCTGGTTTATTGTGGCCGAACTCTTCAGCCAGGGCCCCCGCCCAGCT
GCGATGGCAGTGGCCGGCTGCTCCAACTGGACCTCCAACTTCCTAGTCGGATTGCTCTTC
CCCTCCGCTGCTCACTATTTAGGAGCCTACGTTTTTATTATCTTCACCGGCTTCCTCATT
ACCTTCTTGGCTTTTACCTTCTTCAAAGTCCCTGAGACCCGTGGCAGGACTTTTGAGGAT
ATCACACGGGCCTTTGAAGGGCAGGCACACGGTGCAGATAGATCTGGAAAGGACGGCGTC
ATGGAGATGAACAGCATCGAGCCTGCTAAGGAGACCACCACCAATGTCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11007
Chromosome Location12
LocusNot Available
References
  1. Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB, Bell GI: Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem. 1988 Oct 25;263(30):15245-8. 3170580
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  4. Seatter MJ, De la Rue SA, Porter LM, Gould GW: QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry. 1998 Feb 3;37(5):1322-6. 9477959
  5. Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, Ren W, Hirata K, Yamamoto M, Fan S, Yan N: Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015 Oct 15;526(7573):391-6. doi: 10.1038/nature14655. Epub 2015 Jul 15. 26176916