Solute carrier family 2, facilitated glucose transporter member 1

NameSolute carrier family 2, facilitated glucose transporter member 1
Synonyms
  • Glucose transporter type 1, erythrocyte/brain
  • GLUT-1
  • GLUT1
  • HepG2 glucose transporter
Gene NameSLC2A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016298|Solute carrier family 2, facilitated glucose transporter member 1
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTT
LTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFE
MLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIM
GNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHD
LQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEK
AGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQ
LPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGM
CFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPE
ELFHPLGADSQV
Number of residues492
Molecular Weight54083.325
Theoretical pI8.91
GO Classification
Functions
  • protein self-association
  • identical protein binding
  • glucose transmembrane transporter activity
  • D-glucose transmembrane transporter activity
  • dehydroascorbic acid transporter activity
  • xenobiotic transporter activity
Processes
  • cellular response to glucose starvation
  • carbohydrate metabolic process
  • response to osmotic stress
  • transmembrane transport
  • lactose biosynthetic process
  • glucose transport
  • energy reserve metabolic process
  • regulation of insulin secretion
  • hexose transport
  • glucose transmembrane transport
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • protein complex assembly
  • L-ascorbic acid metabolic process
  • small molecule metabolic process
Components
  • cortical actin cytoskeleton
  • cytosol
  • extracellular exosome
  • melanosome
  • cell-cell junction
  • integral component of plasma membrane
  • Golgi membrane
  • basolateral plasma membrane
  • midbody
  • blood microparticle
  • membrane
  • female pronucleus
  • caveola
  • plasma membrane
General FunctionXenobiotic transporter activity
Specific FunctionFacilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
Pfam Domain Function
Transmembrane Regions12-33 67-87 91-112 121-144 156-176 186-206 272-293 307-328 335-355 366-388 402-422 430-450
GenBank Protein ID183303
UniProtKB IDP11166
UniProtKB Entry NameGTR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016299|Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
ATGGAGCCCAGCAGCAAGAAGCTGACGGGTCGCCTCATGCTGGCCGTGGGAGGAGCAGTG
CTTGGCTCCCTGCAGTTTGGCTACAACACTGGAGTCATCAATGCCCCCCAGAAGGTGATC
GAGGAGTTCTACAACCAGACATGGGTCCACCGCTATGGGGAGAGCATCCTGCCCACCACG
CTCACCACGCTCTGGTCCCTCTCAGTGGCCATCTTTTCTGTTGGGGGCATGATTGGCTCC
TTCTCTGTGGGCCTTTTCGTTAACCGCTTTGGCCGGCGGAATTCAATGCTGATGATGAAC
CTGCTGGCCTTCGTGTCCGCCGTGCTCATGGGCTTCTCGAAACTGGGCAAGTCCTTTGAG
ATGCTGATCCTGGGCCGCTTCATCATCGGTGTGTACTGCGGCCTGACCACAGGCTTCGTG
CCCATGTATGTGGGTGAAGTGTCACCCACAGCCCTTCGTGGGGCCCTGGGCACCCTGCAC
CAGCTGGGCATCGTCGTCGGCATCCTCATCGCCCAGGTGTTCGGCCTGGACTCCATCATG
GGCAACAAGGACCTGTGGCCCCTGCTGCTGAGCATCATCTTCATCCCGGCCCTGCTGCAG
TGCATCGTGCTGCCCTTCTGCCCCGAGAGTCCCCGCTTCCTGCTCATCAACCGCAACGAG
GAGAACCGGGCCAAGAGTGTGCTAAAGAAGCTGCGCGGGACAGCTGACGTGACCCATGAC
CTGCAGGAGATGAAGGAAGAGAGTCGGCAGATGATGCGGGAGAAGAAGGTCACCATCCTG
GAGCTGTTCCGCTCCCCCGCCTACCGCCAGCCCATCCTCATCGCTGTGGTGCTGCAGCTG
TCCCAGCAGCTGTCTGGCATCAACGCTGTCTTCTATTACTCCACGAGCATCTTCGAGAAG
GCGGGGGTGCAGCAGCCTGTGTATGCCACCATTGGCTCCGGTATCGTCAACACGGCCTTC
ACTGTCGTGTCGCTGTTTGTGGTGGAGCGAGCAGGCCGGCGGACCCTGCACCTCATAGGC
CTCGCTGGCATGGCGGGTTGTGCCATACTCATGACCATCGCGCTAGCACTGCTGGAGCAG
CTACCCTGGATGTCCTATCTGAGCATCGTGGCCATCTTTGGCTTTGTGGCCTTCTTTGAA
GTGGGTCCTGGCCCCATCCCATGGTTCATCGTGGCTGAACTCTTCAGCCAGGGTCCACGT
CCAGCTGCCATTGCCGTTGCAGGCTTCTCCAACTGGACCTCAAATTTCATTGTGGGCATG
TGCTTCCAGTATGTGGAGCAACTGTGTGGTCCCTACGTCTTCATCATCTTCACTGTGCTC
CTGGTTCTGTTCTTCATCTTCACCTACTTCAAAGTTCCTGAGACTAAAGGCCGGACCTTC
GATGAGATCGCTTCCGGCTTCCGGCAGGGGGGAGCCAGCCAAAGTGACAAGACACCCGAG
GAGCTGTTCCATCCCCTGGGGGCTGATTCCCAAGTGTGA
GenBank Gene IDK03195
GeneCard IDNot Available
GenAtlas IDSLC2A1
HGNC IDHGNC:11005
Chromosome Location1
Locus1p35-p31.3
References
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