78 kDa glucose-regulated protein

Name78 kDa glucose-regulated protein
Synonyms
  • BiP
  • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
  • GRP-78
  • GRP78
  • Heat shock 70 kDa protein 5
  • Immunoglobulin heavy chain-binding protein
Gene NameHSPA5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019062|78 kDa glucose-regulated protein
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
Number of residues654
Molecular Weight72332.425
Theoretical pI4.8
GO Classification
Functions
  • ATPase activity
  • glycoprotein binding
  • ubiquitin protein ligase binding
  • unfolded protein binding
  • protein domain specific binding
  • enzyme binding
  • ribosome binding
  • misfolded protein binding
  • ATP binding
  • chaperone binding
  • calcium ion binding
Processes
  • regulation of ATF6-mediated unfolded protein response
  • IRE1-mediated unfolded protein response
  • platelet degranulation
  • ER-associated ubiquitin-dependent protein catabolic process
  • cellular response to glucose starvation
  • endoplasmic reticulum unfolded protein response
  • PERK-mediated unfolded protein response
  • ATF6-mediated unfolded protein response
  • protein folding in endoplasmic reticulum
  • cellular response to interleukin-4
  • platelet activation
  • toxin transport
  • positive regulation of protein ubiquitination
  • cerebellar Purkinje cell layer development
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • substantia nigra development
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • regulation of IRE1-mediated unfolded protein response
  • positive regulation of cell migration
  • activation of signaling protein activity involved in unfolded protein response
  • blood coagulation
  • regulation of PERK-mediated unfolded protein response
  • cellular protein metabolic process
  • cerebellum structural organization
  • regulation of protein folding in endoplasmic reticulum
  • negative regulation of protein homodimerization activity
  • ER overload response
  • cellular response to antibiotic
  • negative regulation of apoptotic process
  • maintenance of protein localization in endoplasmic reticulum
Components
  • endoplasmic reticulum
  • plasma membrane
  • focal adhesion
  • endoplasmic reticulum membrane
  • midbody
  • endoplasmic reticulum chaperone complex
  • melanosome
  • cell surface
  • extracellular exosome
  • mitochondrion
  • myelin sheath
  • membrane
  • smooth endoplasmic reticulum
  • endoplasmic reticulum lumen
  • endoplasmic reticulum-Golgi intermediate compartment
  • integral component of endoplasmic reticulum membrane
  • nucleus
General FunctionUnfolded protein binding
Specific FunctionProbably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID386758
UniProtKB IDP11021
UniProtKB Entry NameGRP78_HUMAN
Cellular LocationEndoplasmic reticulum lumen
Gene sequence
>lcl|BSEQ0019063|78 kDa glucose-regulated protein (HSPA5)
ATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAG
GAGGACAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACCTGGGGACCACCTACTCC
TGCGTCGGCGTGTTCAAGAACGGCCGCGTGGAGATCATCGCCAACGATCAGGGCAACCGC
ATCACGCCGTCCTATGTCGCCTTCACTCCTGAAGGGGAACGTCTGATTGGCGATGCCGCC
AAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGACGCCAAGCGGCTCATCGGC
CGCACGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAGGTGGTT
GAAAAGAAAACTAAACCATACATTCAAGTTGATATTGGAGGTGGGCAAACAAAGACATTT
GCTCCTGAAGAAATTTCTGCCATGGTTCTCACTAAAATGAAAGAAACCGCTGAGGCTTAT
TTGGGAAAGAAGGTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAA
CGCCAAGCAACCAAAGACGCTGGAACTATTGCTGGCCTAAATGTTATGAGGATCATCAAC
GAGCCTACGGCAGCTGCTATTGCTTATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATC
CTGGTGTTTGACCTGGGTGGCGGAACCTTCGATGTGTCTCTTCTCACCATTGACAATGGT
GTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGAGAAGACTTTGACCAG
CGTGTCATGGAACACTTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAA
GACAATAGAGCTGTGCAGAAACTCCGGCGCGAGGTAGAAAAGGCCAAACGGGCCCTGTCT
TCTCAGCATCAAGCAAGAATTGAAATTGAGTCCTTCTATGAAGGAGAAGACTTTTCTGAG
ACCCTGACTCGGGCCAAATTTGAAGAGCTCAACATGGATCTGTTCCGGTCTACTATGAAG
CCCGTCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAATTGTT
CTTGTTGGTGGCTCGACTCGAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAAT
GGCAAGGAACCATCCCGTGGCATAAACCCAGATGAAGCTGTAGCGTATGGTGCTGCTGTC
CAGGCTGGTGTGCTCTCTGGTGATCAAGATACAGGTGACCTGGTACTGCTTGATGTATGT
CCCCTTACACTTGGTATTGAAACTGTGGGAGGTGTCATGACCAAACTGATTCCAAGGAAC
ACAGTGGTGCCTACCAAGAAGTCTCAGATCTTTTCTACAGCTTCTGATAATCAACCAACT
GTTACAATCAAGGTCTATGAAGGTGAAAGACCCCTGACAAAAGACAATCATCTTCTGGGT
ACATTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTCCCACAGATTGAAGTCACC
TTTGAGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAAC
AAAAATAAGATCACAATCACCAATGACCAGAATCGCCTGACACCTGAAGAAATCGAAAGG
ATGGTTAATGATGCTGAGAAGTTTGCTGAGGAAGACAAAAAGCTCAAGGAGCGCATTGAT
ACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATAAAGAA
AAGCTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAA
AAGATTGAATGGCTGGAAAGCCACCAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAG
AAGGAACTGGAAGAAATTGTTCAACCAATTATCAGCAAACTCTATGGAAGTGCAGGCCCT
CCCCCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAG
GenBank Gene IDM19645
GeneCard IDNot Available
GenAtlas IDHSPA5
HGNC IDHGNC:5238
Chromosome Location9
Locus9q33-q34.1
References
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