Thioredoxin

NameThioredoxin
Synonyms
  • ADF
  • ATL-derived factor
  • SASP
  • Surface-associated sulphydryl protein
  • TRDX
  • TRX
  • TRX1
Gene NameTXN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008733|Thioredoxin
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
Number of residues105
Molecular Weight11737.42
Theoretical pINot Available
GO Classification
Functions
  • poly(A) RNA binding
  • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
  • peptide disulfide oxidoreductase activity
  • protein disulfide oxidoreductase activity
Processes
  • negative regulation of hydrogen peroxide-induced cell death
  • response to radiation
  • nucleobase-containing small molecule interconversion
  • cell redox homeostasis
  • cell proliferation
  • positive regulation of DNA binding
  • sulfate assimilation
  • positive regulation of protein kinase B signaling
  • gene expression
  • activation of protein kinase B activity
  • small molecule metabolic process
  • response to reactive oxygen species
  • transcription initiation from RNA polymerase II promoter
  • negative regulation of protein export from nucleus
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • innate immune response
  • glycerol ether metabolic process
  • oxidation-reduction process
  • signal transduction
  • positive regulation of peptidyl-serine phosphorylation
  • regulation of protein import into nucleus, translocation
  • nucleobase-containing small molecule metabolic process
  • protein folding
  • negative regulation of transcription from RNA polymerase II promoter
  • movement of cell or subcellular component
  • cell-cell signaling
Components
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • cytoplasm
  • mitochondrion
  • nucleus
General FunctionProtein disulfide oxidoreductase activity
Specific FunctionParticipates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP10599
UniProtKB Entry NameTHIO_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017575|Thioredoxin (TXN)
ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGAT
AAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCT
TTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTT
AAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACC
ATTAATGAATTAGTCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12435
Chromosome Location9
LocusNot Available
References
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