Apoptosis regulator Bcl-2

NameApoptosis regulator Bcl-2
SynonymsNot Available
Gene NameBCL2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000491|Apoptosis regulator Bcl-2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Number of residues239
Molecular Weight26265.66
Theoretical pI7.32
GO Classification
Functions
  • channel activity
  • ubiquitin protein ligase binding
  • identical protein binding
  • BH3 domain binding
  • sequence-specific DNA binding
  • channel inhibitor activity
  • protease binding
  • protein heterodimerization activity
  • protein homodimerization activity
Processes
  • regulation of cell-matrix adhesion
  • mesenchymal cell development
  • male gonad development
  • homeostasis of number of cells within a tissue
  • lymphoid progenitor cell differentiation
  • response to glucocorticoid
  • axon regeneration
  • intrinsic apoptotic signaling pathway in response to oxidative stress
  • negative regulation of cellular pH reduction
  • protein dephosphorylation
  • positive regulation of catalytic activity
  • melanocyte differentiation
  • regulation of calcium ion transport
  • protein polyubiquitination
  • negative regulation of myeloid cell apoptotic process
  • negative regulation of mitochondrial depolarization
  • cellular response to DNA damage stimulus
  • response to cytokine
  • branching involved in ureteric bud morphogenesis
  • positive regulation of neuron maturation
  • response to toxic substance
  • ovarian follicle development
  • organ growth
  • actin filament organization
  • negative regulation of retinal cell programmed cell death
  • innate immune response
  • negative regulation of neuron apoptotic process
  • oocyte development
  • negative regulation of ossification
  • female pregnancy
  • response to gamma radiation
  • metanephros development
  • pigment granule organization
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • ossification
  • T cell differentiation in thymus
  • B cell lineage commitment
  • response to drug
  • axonogenesis
  • response to ischemia
  • extrinsic apoptotic signaling pathway via death domain receptors
  • positive regulation of melanocyte differentiation
  • transmembrane transport
  • intrinsic apoptotic signaling pathway
  • thymus development
  • regulation of mitochondrial membrane permeability
  • programmed cell death
  • gland morphogenesis
  • positive regulation of intrinsic apoptotic signaling pathway
  • positive regulation of skeletal muscle fiber development
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  • B cell homeostasis
  • regulation of transmembrane transporter activity
  • hair follicle morphogenesis
  • ear development
  • response to hydrogen peroxide
  • peptidyl-serine phosphorylation
  • regulation of viral genome replication
  • humoral immune response
  • cell growth
  • neuron apoptotic process
  • negative regulation of apoptotic signaling pathway
  • endoplasmic reticulum calcium ion homeostasis
  • post-embryonic development
  • response to nicotine
  • release of cytochrome c from mitochondria
  • negative regulation of G1/S transition of mitotic cell cycle
  • response to radiation
  • positive regulation of smooth muscle cell migration
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • renal system process
  • apoptotic process
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • extrinsic apoptotic signaling pathway in absence of ligand
  • regulation of protein homodimerization activity
  • regulation of nitrogen utilization
  • cellular response to hypoxia
  • positive regulation of B cell proliferation
  • regulation of glycoprotein biosynthetic process
  • negative regulation of apoptotic process
  • response to iron ion
  • negative regulation of calcium ion transport into cytosol
  • regulation of protein heterodimerization activity
  • cellular response to glucose starvation
  • focal adhesion assembly
  • negative regulation of reactive oxygen species metabolic process
  • positive regulation of peptidyl-serine phosphorylation
  • negative regulation of intrinsic apoptotic signaling pathway
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • digestive tract morphogenesis
  • regulation of mitochondrial membrane potential
  • B cell receptor signaling pathway
  • response to UV-B
  • positive regulation of cell growth
  • positive regulation of multicellular organism growth
  • glomerulus development
  • cochlear nucleus development
  • reactive oxygen species metabolic process
  • negative regulation of autophagy
  • regulation of gene expression
  • negative regulation of cell growth
  • spleen development
  • CD8-positive, alpha-beta T cell lineage commitment
  • negative regulation of cell migration
  • regulation of protein stability
  • cell aging
  • cellular response to organic substance
  • T cell homeostasis
  • melanin metabolic process
  • peptidyl-threonine phosphorylation
  • defense response to virus
  • negative regulation of osteoblast proliferation
  • B cell proliferation
  • behavioral fear response
  • negative regulation of anoikis
Components
  • myelin sheath
  • mitochondrion
  • nuclear membrane
  • membrane
  • nucleus
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • pore complex
  • mitochondrial outer membrane
  • cytosol
  • cytoplasm
General FunctionUbiquitin protein ligase binding
Specific FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Pfam Domain Function
Transmembrane Regions212-233
GenBank Protein ID179367
UniProtKB IDP10415
UniProtKB Entry NameBCL2_HUMAN
Cellular LocationMitochondrion outer membrane
Gene sequence
>lcl|BSEQ0021924|Apoptosis regulator Bcl-2 (BCL2)
ATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGACCCTCCGCCAGGCC
GGCGACGACTTCTCCCGCCGCTACCGCCGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA
GenBank Gene IDM13994
GeneCard IDNot Available
GenAtlas IDBCL2
HGNC IDHGNC:990
Chromosome Location18
Locus18q21.33|18q21.3
References
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