Retinoic acid receptor alpha

NameRetinoic acid receptor alpha
Synonyms
  • NR1B1
  • Nuclear receptor subfamily 1 group B member 1
  • RAR-alpha
Gene NameRARA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001322|Retinoic acid receptor alpha
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Number of residues462
Molecular Weight50770.805
Theoretical pI7.95
GO Classification
Functions
  • steroid hormone receptor activity
  • chromatin DNA binding
  • receptor binding
  • transcription factor activity, sequence-specific DNA binding
  • retinoic acid receptor activity
  • transcription factor binding
  • protein domain specific binding
  • retinoic acid-responsive element binding
  • RNA polymerase II regulatory region sequence-specific DNA binding
  • protein heterodimerization activity
  • enzyme binding
  • transcription corepressor activity
  • alpha-actinin binding
  • transcription coactivator activity
  • protein kinase A binding
  • retinoic acid binding
  • protein kinase B binding
  • zinc ion binding
Processes
  • neural tube closure
  • positive regulation of interleukin-5 production
  • cellular response to retinoic acid
  • negative regulation of tumor necrosis factor production
  • signal transduction
  • Sertoli cell fate commitment
  • positive regulation of transcription, DNA-templated
  • growth plate cartilage development
  • trachea cartilage development
  • multicellular organism growth
  • negative regulation of cartilage development
  • negative regulation of apoptotic process
  • positive regulation of binding
  • chondroblast differentiation
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of granulocyte differentiation
  • spermatogenesis
  • protein phosphorylation
  • negative regulation of transcription, DNA-templated
  • positive regulation of T-helper 2 cell differentiation
  • positive regulation of cell proliferation
  • negative regulation of interferon-gamma production
  • limb development
  • retinoic acid receptor signaling pathway
  • embryonic camera-type eye development
  • ventricular cardiac muscle cell differentiation
  • negative regulation of transcription from RNA polymerase II promoter
  • gene expression
  • cellular response to lipopolysaccharide
  • transcription initiation from RNA polymerase II promoter
  • face development
  • cellular response to estrogen stimulus
  • response to retinoic acid
  • outflow tract septum morphogenesis
  • germ cell development
  • positive regulation of interleukin-4 production
  • glandular epithelial cell development
  • positive regulation of cell cycle
  • apoptotic cell clearance
  • positive regulation of interleukin-13 production
  • negative regulation of translational initiation
  • ureteric bud development
Components
  • nuclear chromatin
  • nucleus
  • dendrite
  • cell surface
  • actin cytoskeleton
  • neuronal cell body
  • nucleoplasm
  • cytoplasm
General FunctionZinc ion binding
Specific FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36157
UniProtKB IDP10276
UniProtKB Entry NameRARA_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016168|Retinoic acid receptor alpha (RARA)
ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCG
GTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCT
CTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACC
ATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCT
CTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTAT
GGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATG
GTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGC
CAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAAC
GACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTG
ACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCT
GCCCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTG
GACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTG
GAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTC
CTCAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAG
CAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCT
GGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAG
ATGGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAG
GACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAG
GTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAG
ATTACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATG
GAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTG
GACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCG
CCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCAC
TCCCCGTGA
GenBank Gene IDX06614
GeneCard IDNot Available
GenAtlas IDRARA
HGNC IDHGNC:9864
Chromosome Location17
Locus17q21
References
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