Interleukin-8

NameInterleukin-8
Synonyms
  • C-X-C motif chemokine 8
  • Chemokine (C-X-C motif) ligand 8
  • Emoctakin
  • GCP-1
  • Granulocyte chemotactic protein 1
  • IL-8
  • IL8
  • MDNCF
  • MONAP
  • Monocyte-derived neutrophil chemotactic factor
  • Monocyte-derived neutrophil-activating peptide
  • NAP-1
  • Neutrophil-activating protein 1
  • Protein 3-10C
  • T-cell chemotactic factor
Gene NameCXCL8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001913|Interleukin-8
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
Number of residues99
Molecular Weight11097.98
Theoretical pI9.09
GO Classification
Functions
  • chemokine activity
  • interleukin-8 receptor binding
Processes
  • neutrophil activation
  • cellular protein metabolic process
  • cellular response to interleukin-1
  • negative regulation of cell proliferation
  • induction of positive chemotaxis
  • G-protein coupled receptor signaling pathway
  • negative regulation of G-protein coupled receptor protein signaling pathway
  • neutrophil chemotaxis
  • signal transduction
  • positive regulation of neutrophil chemotaxis
  • intracellular signal transduction
  • calcium-mediated signaling
  • regulation of single stranded viral RNA replication via double stranded DNA intermediate
  • angiogenesis
  • immune response
  • response to molecule of bacterial origin
  • cellular response to lipopolysaccharide
  • movement of cell or subcellular component
  • embryonic digestive tract development
  • inflammatory response
  • endoplasmic reticulum unfolded protein response
  • cell cycle arrest
  • PERK-mediated unfolded protein response
  • chemotaxis
  • positive regulation of angiogenesis
  • regulation of cell adhesion
  • response to endoplasmic reticulum stress
  • receptor internalization
  • cellular response to fibroblast growth factor stimulus
  • chemokine-mediated signaling pathway
  • cellular response to tumor necrosis factor
Components
  • intracellular
  • extracellular region
  • extracellular space
General FunctionInterleukin-8 receptor binding
Specific FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID34519
UniProtKB IDP10145
UniProtKB Entry NameIL8_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010675|Interleukin-8 (CXCL8)
ATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGCAGCTCTGTGT
GAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATAC
TCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACAC
TGCGCCAACACAGAAATTATTGTAAAGCTTTCTGATGGAAGAGAGCTCTGTCTGGACCCC
AAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGCTGAGAATTCATAA
GenBank Gene IDY00787
GeneCard IDNot Available
GenAtlas IDIL8
HGNC IDHGNC:6025
Chromosome Location4
Locus4q13-q21
References
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