Adrenodoxin, mitochondrial

NameAdrenodoxin, mitochondrial
Synonyms
  • Adrenal ferredoxin
  • ADX
  • Ferredoxin-1
  • Hepatoredoxin
Gene NameFDX1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010215|Adrenodoxin, mitochondrial
MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARAR
SSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFE
DHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDV
GKTS
Number of residues184
Molecular Weight19392.475
Theoretical pI5.62
GO Classification
Functions
  • electron carrier activity
  • 2 iron, 2 sulfur cluster binding
  • iron ion binding
Processes
  • small molecule metabolic process
  • oxidation-reduction process
  • steroid metabolic process
  • cholesterol metabolic process
  • xenobiotic metabolic process
  • C21-steroid hormone biosynthetic process
  • hormone biosynthetic process
  • sterol metabolic process
Components
  • mitochondrial matrix
  • mitochondrion
General FunctionIron ion binding
Specific FunctionParticipates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID557734
UniProtKB IDP10109
UniProtKB Entry NameADX_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0010216|Adrenodoxin, mitochondrial (FDX1)
ATGGCTGCCGCTGGGGGCGCCCGGCTGCTGCGCGCCGCTTCTGCTGTCCTCGGCGGCCCG
GCCGGCCGGTGGCTGCACCACGCTGGGTCCCGCGCTGGATCCAGCGGCCTGCTGAGGAAC
CGGGGGCCGGGCGGGAGCGCGGAGGCGAGCCGGTCGCTGAGCGTGTCGGCGCGGGCCCGG
AGCAGCTCAGAAGATAAAATAACAGTCCACTTTATAAACCGTGATGGTGAAACATTAACA
ACCAAAGGAAAAGTTGGTGATTCTCTGCTAGATGTTGTGGTTGAAAATAATCTAGATATT
GATGGCTTTGGTGCATGTGAGGGAACCCTGGCTTGTTCAACCTGTCACCTCATCTTTGAA
GATCACATATATGAGAAGTTAGATGCAATCACTGATGAGGAGAATGACATGCTCGATCTG
GCATATGGACTAACAGACAGATCACGGTTGGGCTGCCAAATCTGTTTGACAAAATCTATG
GACAATATGACTGTTCGAGTGCCTGAAACAGTGGCTGATGCCAGACAATCCATTGATGTG
GGCAAGACCTCCTGA
GenBank Gene IDM23668
GeneCard IDNot Available
GenAtlas IDFDX1
HGNC IDHGNC:3638
Chromosome Location11
Locus11q22
References
  1. Chang CY, Wu DA, Lai CC, Miller WL, Chung BC: Cloning and structure of the human adrenodoxin gene. DNA. 1988 Nov;7(9):609-15. 3229285
  2. Picado-Leonard J, Voutilainen R, Kao LC, Chung BC, Strauss JF 3rd, Miller WL: Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells. J Biol Chem. 1988 Mar 5;263(7):3240-4. 3343244
  3. Mittal S, Zhu YZ, Vickery LE: Molecular cloning and sequence analysis of human placental ferredoxin. Arch Biochem Biophys. 1988 Aug 1;264(2):383-91. 2969697
  4. Chang CY, Wu DA, Mohandas TK, Chung BC: Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family. DNA Cell Biol. 1990 Apr;9(3):205-12. 2340092
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