Calmodulin

NameCalmodulin
Synonyms
  • CALM
  • CALML2
  • CAM
  • CAM1
  • CAM2
  • CAM3
  • CAMB
  • CAMC
  • CAMIII
Gene NameCALM1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037013|Calmodulin
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Number of residues149
Molecular Weight16837.47
Theoretical pI3.84
GO Classification
Functions
  • protein kinase binding
  • nitric-oxide synthase regulator activity
  • thioesterase binding
  • protein domain specific binding
  • protein phosphatase activator activity
  • N-terminal myristoylation domain binding
  • ion channel binding
  • titin binding
  • protein serine/threonine kinase activator activity
  • calcium ion binding
  • phospholipase binding
Processes
  • positive regulation of protein serine/threonine kinase activity
  • positive regulation of ryanodine-sensitive calcium-release channel activity
  • Fc-epsilon receptor signaling pathway
  • activation of adenylate cyclase activity
  • regulation of high voltage-gated calcium channel activity
  • small GTPase mediated signal transduction
  • activation of MAPKK activity
  • synaptic transmission
  • activation of phospholipase C activity
  • positive regulation of protein autophosphorylation
  • fibroblast growth factor receptor signaling pathway
  • regulation of cell communication by electrical coupling involved in cardiac conduction
  • response to corticosterone
  • insulin receptor signaling pathway
  • platelet activation
  • positive regulation of nitric-oxide synthase activity
  • regulation of rhodopsin mediated signaling pathway
  • MAPK cascade
  • rhodopsin mediated signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • small molecule metabolic process
  • regulation of heart rate
  • detection of calcium ion
  • Ras protein signal transduction
  • positive regulation of phosphoprotein phosphatase activity
  • stimulatory C-type lectin receptor signaling pathway
  • regulation of cytokinesis
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
  • vascular endothelial growth factor receptor signaling pathway
  • carbohydrate metabolic process
  • muscle contraction
  • negative regulation of ryanodine-sensitive calcium-release channel activity
  • membrane organization
  • glucose metabolic process
  • positive regulation of protein dephosphorylation
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
  • signal transduction
  • platelet degranulation
  • glycogen catabolic process
  • substantia nigra development
  • negative regulation of peptidyl-threonine phosphorylation
  • blood coagulation
  • G-protein coupled receptor signaling pathway
  • positive regulation of peptidyl-threonine phosphorylation
  • nitric oxide metabolic process
  • regulation of nitric-oxide synthase activity
  • response to amphetamine
  • inositol phosphate metabolic process
  • axon guidance
  • regulation of cardiac muscle contraction
  • positive regulation of cyclic nucleotide metabolic process
  • response to calcium ion
  • epidermal growth factor receptor signaling pathway
  • positive regulation of cyclic-nucleotide phosphodiesterase activity
  • phototransduction, visible light
  • innate immune response
Components
  • plasma membrane
  • spindle microtubule
  • growth cone
  • vesicle
  • cytosol
  • sarcomere
  • extracellular exosome
  • cytoplasm
  • nucleoplasm
  • extracellular region
  • spindle pole
  • centrosome
  • nucleus
General FunctionTitin binding
Specific FunctionCalmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID179888
UniProtKB IDP0DP23
UniProtKB Entry NameCALM_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021651|Calmodulin (CALM1)
ATGGCTGATCAGCTGACCGAAGAACAGATTGCTGAATTCAAGGAAGCCTTCTCCCTATTT
GATAAAGATGGCGATGGCACCATCACAACAAAGGAACTTGGAACTGTCATGAGGTCACTG
GGTCAGAACCCAACAGAAGCTGAATTGCAGGATATGATCAATGAAGTGGATGCTGATGGT
AATGGCACCATTGACTTCCCCGAATTTTTGACTATGATGGCTAGAAAAATGAAAGATACA
GATAGTGAAGAAGAAATCCGTGAGGCATTCCGAGTCTTTGACAAGGATGGCAATGGTTAT
ATCAGTGCAGCAGAACTACGTCACGTCATGACAAACTTAGGAGAAAAACTAACAGATGAA
GAAGTAGATGAAATGATCAGAGAAGCAGATATTGATGGAGACGGACAAGTCAACTATGAA
GAATTCGTACAGATGATGACTGCAAAATGA
GenBank Gene IDJ04046
GeneCard IDNot Available
GenAtlas IDCALM1
HGNC IDHGNC:1442
Chromosome Location19
Locus14q24-q31
References
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