Histone H2A type 1

NameHistone H2A type 1
Synonyms
  • H2A.1
  • H2AFC
  • H2AFD
  • H2AFI
  • H2AFN
  • H2AFP
  • Histone H2A/p
Gene NameHIST1H2AG
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019684|Histone H2A type 1
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
Number of residues130
Molecular Weight14091.375
Theoretical pINot Available
GO Classification
Functions
  • enzyme binding
  • DNA binding
Processes
  • chromatin silencing
  • chromatin organization
Components
  • nucleus
  • extracellular exosome
  • nuclear chromatin
  • nucleosome
General FunctionEnzyme binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP0C0S8
UniProtKB Entry NameH2A1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019685|Histone H2A type 1 (HIST1H2AG)
ATGTCTGGGCGTGGCAAGCAGGGAGGCAAAGCTCGCGCCAAGGCCAAGACCCGCTCTTCT
CGGGCCGGGCTTCAGTTTCCCGTAGGCCGAGTGCATCGCCTGCTCCGCAAAGGCAACTAT
GCGGAGCGGGTCGGTGCTGGAGCGCCGGTGTACCTGGCGGCGGTGCTGGAGTACCTGACC
GCCGAGATCCTGGAGCTGGCTGGCAACGCGGCCCGCGACAACAAGAAGACTCGCATCATC
CCGCGTCACCTCCAGCTGGCCATCCGCAACGATGAGGAGCTCAACAAGCTTCTGGGCAAA
GTCACCATCGCACAGGGTGGCGTCCTGCCCAACATCCAGGCCGTGCTACTGCCCAAGAAG
ACCGAGAGCCACCACAAGGCGAAGGGCAAGTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4737
Chromosome Location6
LocusNot Available
References
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