Macrophage colony-stimulating factor 1

NameMacrophage colony-stimulating factor 1
Synonyms
  • CSF-1
  • Lanimostim
Gene NameCSF1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037132|Macrophage colony-stimulating factor 1
MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQME
TSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK
SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSS
QDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQP
LHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMG
TNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPA
DVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLS
AQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTG
HERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEG
SPLTQDDRQVELPV
Number of residues554
Molecular Weight60178.885
Theoretical pI4.94
GO Classification
Functions
  • macrophage colony-stimulating factor receptor binding
  • growth factor activity
  • cytokine activity
  • protein homodimerization activity
Processes
  • positive regulation of cell proliferation
  • positive regulation of macrophage differentiation
  • positive regulation of cellular protein metabolic process
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • positive regulation of macrophage derived foam cell differentiation
  • branching involved in mammary gland duct morphogenesis
  • positive regulation of gene expression
  • developmental process involved in reproduction
  • macrophage differentiation
  • mammary duct terminal end bud growth
  • positive regulation of multicellular organism growth
  • mammary gland fat development
  • positive regulation of Ras protein signal transduction
  • regulation of ossification
  • monocyte activation
  • inflammatory response
  • osteoclast proliferation
  • hemopoiesis
  • cell proliferation
  • positive regulation of macrophage colony-stimulating factor signaling pathway
  • macrophage colony-stimulating factor signaling pathway
  • positive regulation of microglial cell migration
  • osteoclast differentiation
  • positive regulation of monocyte differentiation
  • positive regulation of mononuclear cell proliferation
  • positive regulation of osteoclast differentiation
  • positive regulation of odontogenesis of dentin-containing tooth
  • positive regulation of cell-matrix adhesion
  • regulation of macrophage derived foam cell differentiation
  • positive regulation of protein kinase activity
  • cell differentiation
  • homeostasis of number of cells within a tissue
  • innate immune response
  • positive regulation of cell migration
  • positive regulation of macrophage chemotaxis
Components
  • membrane
  • plasma membrane
  • extracellular space
  • CSF1-CSF1R complex
  • integral component of membrane
  • extracellular exosome
  • perinuclear region of cytoplasm
General FunctionProtein homodimerization activity
Specific FunctionCytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Pfam Domain Function
Transmembrane Regions497-517
GenBank Protein ID181144
UniProtKB IDP09603
UniProtKB Entry NameCSF1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010809|Macrophage colony-stimulating factor 1 (CSF1)
ATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGACATGGCTGGGCTCCCTGCTG
TTGTTGGTCTGTCTCCTGGCGAGCAGGAGTATCACCGAGGAGGTGTCGGAGTACTGTAGC
CACATGATTGGGAGTGGACACCTGCAGTCTCTGCAGCGGCTGATTGACAGTCAGATGGAG
ACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGAAAGATCCAGTGTGC
TACCTTAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGACACCATGCGCTTCAGA
GATAACACCCCCAATGCCATCGCCATTGTGCAGCTGCAGGAACTCTCTTTGAGGCTGAAG
AGCTGCTTCACCAAGGATTATGAAGAGCATGACAAGGCCTGCGTCCGAACTTTCTATGAG
ACACCTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTT
GACAAGGACTGGAATATTTTCAGCAAGAACTGCAACAACAGCTTTGCTGAATGCTCCAGC
CAAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCCAAAGCCATCCCTAGCAGT
GACCCGGCCTCTGTCTCCCCTCATCAGCCCCTCGCCCCCTCCATGGCCCCTGTGGCTGGC
TTGACCTGGGAGGACTCTGAGGGAACTGAGGGCAGCTCCCTCTTGCCTGGTGAGCAGCCC
CTGCACACAGTGGATCCAGGCAGTGCCAAGCAGCGGCCACCCAGGAGCACCTGCCAGAGC
TTTGAGCCGCCAGAGACCCCAGTTGTCAAGGACAGCACCATCGGTGGCTCACCACAGCCT
CGCCCCTCTGTCGGGGCCTTCAACCCCGGGATGGAGGATATTCTTGACTCTGCAATGGGC
ACTAATTGGGTCCCAGAAGAAGCCTCTGGAGAGGCCAGTGAGATTCCCGTACCCCAAGGG
ACAGAGCTTTCCCCCTCCAGGCCAGGAGGGGGCAGCATGCAGACAGAGCCCGCCAGACCC
AGCAACTTCCTCTCAGCATCTTCTCCACTCCCTGCATCAGCAAAGGGCCAACAGCCGGCA
GATGTAACTGGTACCGCCTTGCCCAGGGTGGGCCCCGTGAGGCCCACTGGCCAGGACTGG
AATCACACCCCCCAGAAGACAGACCATCCATCTGCCCTGCTCAGAGACCCCCCGGAGCCA
GGCTCTCCCAGGATCTCATCACTGCGCCCCCAGGGCCTCAGCAACCCCTCCACCCTCTCT
GCTCAGCCACAGCTTTCCAGAAGCCACTCCTCGGGCAGCGTGCTGCCCCTTGGGGAGCTG
GAGGGCAGGAGGAGCACCAGGGATCGGAGGAGCCCCGCAGAGCCAGAAGGAGGACCAGCA
AGTGAAGGGGCAGCCAGGCCCCTGCCCCGTTTTAACTCCGTTCCTTTGACTGACACAGGC
CATGAGAGGCAGTCCGAGGGATCCTCCAGCCCGCAGCTCCAGGAGTCTGTCTTCCACCTG
CTGGTGCCCAGTGTCATCCTGGTCTTGCTGGCCGTCGGAGGCCTCTTGTTCTACAGGTGG
AGGCGGCGGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCAGAGGGC
AGCCCCCTGACTCAGGATGACAGACAGGTGGAACTGCCAGTGTAG
GenBank Gene IDM11296
GeneCard IDNot Available
GenAtlas IDCSF1
HGNC IDHGNC:2432
Chromosome Location1
Locus1p21-p13
References
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