NameGlycodelin
Synonyms
  • GD
  • PAEG
  • PEG
  • Placental protein 14
  • PP14
  • Pregnancy-associated endometrial alpha-2 globulin
  • Progestagen-associated endometrial protein
  • Progesterone-associated endometrial protein
Gene NamePAEP
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007570|Glycodelin
MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVH
ITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNF
LFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF
Number of residues180
Molecular Weight20624.015
Theoretical pI5.26
GO Classification
Functions
  • small molecule binding
Processes
  • positive regulation of interleukin-6 secretion
  • positive regulation of granulocyte macrophage colony-stimulating factor production
  • positive regulation of interleukin-13 secretion
  • transport
  • apoptotic process
  • multicellular organismal development
Components
  • extracellular region
General FunctionSmall molecule binding
Specific FunctionThis protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190215
UniProtKB IDP09466
UniProtKB Entry NamePAEP_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0012751|Glycodelin (PAEP)
ATGCTGTGCCTCCTGCTCACCCTGGGCGTGGCCCTGGTCTGTGGTGTCCCGGCCATGGAC
ATCCCCCAGACCAAGCAGGACCTGGAGCTCCCAAAGTTGGCAGGGACCTGGCACTCCATG
GCCATGGCGACCAACAACATCTCCCTCATGGCGACACTGAAGGCCCCTCTGAGGGTCCAC
ATCACCTCACTGTTGCCCACCCCCGAGGACAACCTGGAGATCGTTCTGCACAGATGGGAG
AACAACAGCTGTGTTGAGAAGAAGGTCCTTGGAGAGAAGACTGAGAATCCAAAGAAGTTC
AAGATCAACTATACGGTGGCGAACGAGGCCACGCTGCTCGATACTGACTACGACAATTTC
CTGTTTCTCTGCCTACAGGACACCACCACCCCCATCCAGAGCATGATGTGCCAGTACCTG
GCCAGAGTCCTGGTGGAGGACGATGAGATCATGCAGGGATTCATCAGGGCTTTCAGGCCC
CTGCCCAGGCACCTATGGTACTTGCTGGACTTGAAACAGATGGAAGAGCCGTGCCGTTTC
TAG
GenBank Gene IDJ04129
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:8573
Chromosome Location9
Locus9q34
References
  1. Julkunen M, Seppala M, Janne OA: Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8845-9. 3194393
  2. Vaisse C, Atger M, Potier B, Milgrom E: Human placental protein 14 gene: sequence and characterization of a short duplication. DNA Cell Biol. 1990 Jul-Aug;9(6):401-13. 2206398
  3. Garde J, Bell SC, Eperon IC: Multiple forms of mRNA encoding human pregnancy-associated endometrial alpha 2-globulin, a beta-lactoglobulin homologue. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2456-60. 2006183
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. 17974005
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  7. Bell SC, Keyte JW, Waites GT: Pregnancy-associated endometrial alpha 2-globulin, the major secretory protein of the luteal phase and first trimester pregnancy endometrium, is not glycosylated prolactin but related to beta-lactoglobulins. J Clin Endocrinol Metab. 1987 Nov;65(5):1067-71. 3667877
  8. Huhtala ML, Seppala M, Narvanen A, Palomaki P, Julkunen M, Bohn H: Amino acid sequence homology between human placental protein 14 and beta-lactoglobulins from various species. Endocrinology. 1987 Jun;120(6):2620-2. 3569148
  9. Vigne JL, Hornung D, Mueller MD, Taylor RN: Purification and characterization of an immunomodulatory endometrial protein, glycodelin. J Biol Chem. 2001 May 18;276(20):17101-5. Epub 2001 Mar 5. 11278680
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  12. Koistinen H, Koistinen R, Dell A, Morris HR, Easton RL, Patankar MS, Oehninger S, Clark GF, Seppala M: Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin-A. Mol Hum Reprod. 1996 Oct;2(10):759-65. 9239694