Fibroblast growth factor 2

NameFibroblast growth factor 2
Synonyms
  • Basic fibroblast growth factor
  • bFGF
  • FGF-2
  • FGFB
  • HBGF-2
  • Heparin-binding growth factor 2
Gene NameFGF2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037112|Fibroblast growth factor 2
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAA
GSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAA
PAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG
RVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERL
ESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Number of residues288
Molecular Weight30769.715
Theoretical pI10.01
GO Classification
Functions
  • growth factor activity
  • cytokine activity
  • heparin binding
  • fibroblast growth factor receptor binding
  • ligand-dependent nuclear receptor transcription coactivator activity
  • chemoattractant activity
Processes
  • positive regulation of transcription from RNA polymerase II promoter
  • phosphatidylinositol biosynthetic process
  • positive regulation of endothelial cell proliferation
  • Ras protein signal transduction
  • positive regulation of blood vessel endothelial cell migration
  • organ morphogenesis
  • somatic stem cell population maintenance
  • cell migration involved in sprouting angiogenesis
  • vascular endothelial growth factor receptor signaling pathway
  • negative regulation of fibroblast migration
  • small GTPase mediated signal transduction
  • chondroblast differentiation
  • wound healing
  • chemotaxis
  • positive regulation of cell division
  • nervous system development
  • axon guidance
  • regulation of endothelial cell chemotaxis to fibroblast growth factor
  • embryonic morphogenesis
  • positive regulation of cell proliferation
  • growth factor dependent regulation of skeletal muscle satellite cell proliferation
  • epidermal growth factor receptor signaling pathway
  • negative regulation of blood vessel endothelial cell migration
  • positive regulation of MAP kinase activity
  • inositol phosphate biosynthetic process
  • innate immune response
  • release of sequestered calcium ion into cytosol
  • phosphatidylinositol-mediated signaling
  • positive regulation of cell fate specification
  • Fc-epsilon receptor signaling pathway
  • negative regulation of cell death
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of endothelial cell chemotaxis to fibroblast growth factor
  • extracellular matrix organization
  • positive regulation of transcription, DNA-templated
  • positive regulation of cardiac muscle cell proliferation
  • positive regulation of phosphatidylinositol 3-kinase activity
  • positive regulation of sprouting angiogenesis
  • activation of MAPKK activity
  • positive regulation of phospholipase C activity
  • fibroblast growth factor receptor signaling pathway
  • positive chemotaxis
  • regulation of angiogenesis
  • insulin receptor signaling pathway
  • hyaluronan catabolic process
  • signal transduction
  • negative regulation of wound healing
  • MAPK cascade
  • branching involved in ureteric bud morphogenesis
  • positive regulation of angiogenesis
  • neurotrophin TRK receptor signaling pathway
  • activation of MAPK activity
Components
  • extracellular space
  • extracellular region
  • nucleus
General FunctionLigand-dependent nuclear receptor transcription coactivator activity
Specific FunctionPlays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31362
UniProtKB IDP09038
UniProtKB Entry NameFGF2_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021843|Fibroblast growth factor 2 (FGF2)
CTGGTGGGTGTGGGGGGTGGAGATGTAGAAGATGTGACGCCGCGGCCCGGCGGGTGCCAG
ATTAGCGGACGCGGTGCCCGCGGTTGCAACGGGATCCCGGGCGCTGCAGCTTGGGAGGCG
GCTCTCCCCAGGCGGCGTCCGCGGAGACACCCATCCGTGAACCCCAGGTCCCGGGCCGCC
GGCTCGCCGCGCACCAGGGGCCGGCGGACAGAAGAGCGGCCGAGCGGCTCGAGGCTGGGG
GACCGCGGGCGCGGCCGCGCGCTGCCGGGCGGGAGGCTGGGGGGCCGGGGCCGGGGCCGT
GCCCCGGAGCGGGTCGGAGGCCGGGGCCGGGGCCGGGGGACGGCGGCTCCCCGCGCGGCT
CCAGCGGCTCGGGGATCCCGGCCGGGCCCCGCAGGGACCATGGCAGCCGGGAGCATCACC
ACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCCTTCCCGCCCGGCCACTTCAAG
GACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGC
CGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACATCAAGCTACAACTTCAAGCAGAA
GAGAGAGGAGTTGTGTCTATCAAAGGAGTGTGTGCTAACCGTTACCTGGCTATGAAGGAA
GATGGAAGATTACTGGCTTCTAAATGTGTTACGGATGAGTGTTTCTTTTTTGAACGATTG
GAATCTAATAACTACAATACTTACCGGTCAAGGAAATACACCAGTTGGTATGTGGCACTG
AAACGAACTGGGCAGTATAAACTTGGATCCAAAACAGGACCTGGGCAGAAAGCTATACTT
TTTCTTCCAATGTCTGCTAAGAGCTGA
GenBank Gene IDX04431
GeneCard IDNot Available
GenAtlas IDFGF2
HGNC IDHGNC:3676
Chromosome Location4
Locus4q26-q27
References
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