Low affinity immunoglobulin gamma Fc region receptor III-A

NameLow affinity immunoglobulin gamma Fc region receptor III-A
Synonyms
  • CD16A
  • CD16a antigen
  • Fc-gamma RIII
  • Fc-gamma RIII-alpha
  • Fc-gamma RIIIa
  • FCG3
  • FCGR3
  • FcR-10
  • FcRIII
  • FcRIIIa
  • IGFR3
  • IgG Fc receptor III-2
Gene NameFCGR3A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004112|Low affinity immunoglobulin gamma Fc region receptor III-A
MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQW
FHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKE
EDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKN
VSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDW
KDHKFKWRKDPQDK
Number of residues254
Molecular Weight29088.895
Theoretical pI8.21
GO Classification
Processes
  • immune response
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • innate immune response
  • regulation of immune response
Components
  • plasma membrane
  • integral component of membrane
  • extracellular exosome
  • external side of plasma membrane
General FunctionNot Available
Specific FunctionReceptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Pfam Domain Function
Transmembrane Regions209-229
GenBank Protein ID31324
UniProtKB IDP08637
UniProtKB Entry NameFCG3A_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0011522|Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A)
ATGGGTGGAGGGGCTGGGGAAAGGCTGTTTACTTCCTCCTGTCTAGTCGGTTTGGTCCCT
TTAGGGCTCCGGATATCTTTGGTGACTTGTCCACTCCAGTGTGGCATCATGTGGCAGCTG
CTCCTCCCAACTGCTCTGCTACTTCTAGTTTCAGCTGGCATGCGGACTGAAGATCTCCCA
AAGGCTGTGGTGTTCCTGGAGCCTCAATGGTACAGGGTGCTCGAGAAGGACAGTGTGACT
CTGAAGTGCCAGGGAGCCTACTCCCCTGAGGACAATTCCACACAGTGGTTTCACAATGAG
AGCCTCATCTCAAGCCAGGCCTCGAGCTACTTCATTGACGCTGCCACAGTCGACGACAGT
GGAGAGTACAGGTGCCAGACAAACCTCTCCACCCTCAGTGACCCGGTGCAGCTAGAAGTC
CATATCGGCTGGCTGTTGCTCCAGGCCCCTCGGTGGGTGTTCAAGGAGGAAGACCCTATT
CACCTGAGGTGTCACAGCTGGAAGAACACTGCTCTGCATAAGGTCACATATTTACAGAAT
GGCAAAGGCAGGAAGTATTTTCATCATAATTCTGACTTCTACATTCCAAAAGCCACACTC
AAAGACAGCGGCTCCTACTTCTGCAGGGGGCTTTTTGGGAGTAAAAATGTGTCTTCAGAG
ACTGTGAACATCACCATCACTCAAGGTTTGGCAGTGTCAACCATCTCATCATTCTTTCCA
CCTGGGTACCAAGTCTCTTTCTGCTTGGTGATGGTACTCCTTTTTGCAGTGGACACAGGA
CTATATTTCTCTGTGAAGACAAACATTCGAAGCTCAACAAGAGACTGGAAGGACCATAAA
TTTAAATGGAGAAAGGACCCTCAAGACAAATGA
GenBank Gene IDX52645
GeneCard IDNot Available
GenAtlas IDFCGR3A
HGNC IDHGNC:3619
Chromosome Location1
Locus1q23
References
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