Tyrosine-protein kinase HCK

NameTyrosine-protein kinase HCK
Synonyms
  • 2.7.10.2
  • Hematopoietic cell kinase
  • Hemopoietic cell kinase
  • p59-HCK/p60-HCK
  • p59Hck
  • p61Hck
Gene NameHCK
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002827|Tyrosine-protein kinase HCK
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Number of residues526
Molecular Weight59599.355
Theoretical pI6.68
GO Classification
Functions
  • receptor binding
  • non-membrane spanning protein tyrosine kinase activity
  • protein tyrosine kinase activity
  • ATP binding
Processes
  • cellular response to peptide hormone stimulus
  • peptidyl-tyrosine phosphorylation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • regulation of defense response to virus by virus
  • negative regulation of apoptotic process
  • regulation of sequence-specific DNA binding transcription factor activity
  • protein phosphorylation
  • positive regulation of cell proliferation
  • inflammatory response
  • positive regulation of actin cytoskeleton reorganization
  • integrin-mediated signaling pathway
  • regulation of podosome assembly
  • regulation of inflammatory response
  • regulation of cell shape
  • mesoderm development
  • innate immune response-activating signal transduction
  • cytokine-mediated signaling pathway
  • leukocyte degranulation
  • lipopolysaccharide-mediated signaling pathway
  • leukocyte migration involved in immune response
  • regulation of phagocytosis
  • respiratory burst after phagocytosis
  • protein autophosphorylation
  • cell differentiation
  • positive regulation of actin filament polymerization
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • viral process
  • innate immune response
  • interferon-gamma-mediated signaling pathway
  • peptidyl-tyrosine autophosphorylation
  • cell adhesion
Components
  • cytoskeleton
  • nucleus
  • transport vesicle
  • lysosome
  • caveola
  • Golgi apparatus
  • cytosol
  • extrinsic component of cytoplasmic side of plasma membrane
  • focal adhesion
  • cell projection
General FunctionReceptor binding
Specific FunctionNon-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID306832
UniProtKB IDP08631
UniProtKB Entry NameHCK_HUMAN
Cellular LocationLysosome
Gene sequence
>lcl|BSEQ0021845|Tyrosine-protein kinase HCK (HCK)
ATGGGGTGCATGAAGTCCAAGTTCCTCCAGGTCGGAGGCAATACATTCTCAAAAACTGAA
ACCAGCGCCAGCCCACACTGTCCTGTGTACGTGCCGGATCCCACATCCACCATCAAGCCG
GGGCCTAATAGCCACAACAGCAACACACCAGGAATCAGGGAGGCAGGCTCTGAGGACATC
ATCGTGGTTGCCCTGTATGATTACGAGGCCATTCACCACGAAGACCTCAGCTTCCAGAAG
GGGGACCAGATGGTGGTCCTAGAGGAATCCGGGGAGTGGTGGAAGGCTCGATCCCTGGCC
ACCCGGAAGGAGGGCTACATCCCAAGCAACTATGTCGCCCGCGTTGACTCTCTGGAGACA
GAGGAGTGGTTTTTCAAGGGCATCAGCCGGAAGGACGCAGAGCGCCAACTGCTGGCTCCC
GGCAACATGCTGGGCTCCTTCATGATCCGGGATAGCGAGACCACTAAAGGAAGCTACTCT
TTGTCCGTGCGAGACTACGACCCTCGGCAGGGAGATACCGTGAAACATTACAAGATCCGG
ACCCTGGACAACGGGGGCTTCTACATATCCCCCCGAAGCACCTTCAGCACTCTGCAGGAG
CTGGTGGACCACTACAAGAAGGGGAACGACGGGCTCTGCCAGAAACTGTCGGTGCCCTGC
ATGTCTTCCAAGCCCCAGAAGCCTTGGGAGAAAGATGCCTGGGAGATCCCTCGGGAATCC
CTCAAGCTGGAGAAGAAACTTGGAGCTGGGCAGTTTGGGGAAGTCTGGATGGCCACCTAC
AACAAGCACACCAAGGTGGCAGTGAAGACGATGAAGCCAGGGAGCATGTCGGTGGAGGCC
TTCCTGGCAGAGGCCAACGTGATGAAAACTCTGCAGCATGACAAGCTGGTCAAACTTCAT
GCGGTGGTCACCAAGGAGCCCATCTACATCATCACGGAGTTCATGGCCAAAGGAAGCTTG
CTGGACTTTCTGAAAAGTGATGAGGGCAGCAAGCAGCCATTGCCAAAACTCATTGACTTC
TCAGCCCAGATTGCAGAAGGCATGGCCTTCATCGAGCAGAGGAACTACATCCACCGAGAC
CTCCGAGCTGCCAACATCTTGGTCTCTGCATCCCTGGTGTGTAAGATTGCTGACTTTGGC
CTGGCCCGGGTCATTGAGGACAACGAGTACACGGCTCGGGAAGGGGCCAAGTTCCCCATC
AAGTGGACAGCTCCTGAAGCCATCAACTTTGGCTCCTTCACCATCAAGTCAGACGTCTGG
TCCTTTGGTATCCTGCTGATGGAGATCGTCACCTACGGCCGGATCCCTTACCCAGGGATG
TCAAACCCTGAAGTGATCCGAGCTCTGGAGCGTGGATACCGGATGCCTCGCCCAGAGAAC
TGCCCAGAGGAGCTCTACAACATCATGATGCGCTGCTGGAAAAACCGTCCGGAGGAGCGG
CCGACCTTCGAATACATCCAGAGTGTGCTGGATGACTTCTACACGGCCACAGAGAGCCAG
TACCAACAGCAGCCATGA
GenBank Gene IDM16591
GeneCard IDNot Available
GenAtlas IDHCK
HGNC IDHGNC:4840
Chromosome Location20
Locus20q11-q12
References
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