Cytochrome c1, heme protein, mitochondrial

NameCytochrome c1, heme protein, mitochondrial
Synonyms
  • Complex III subunit 4
  • Complex III subunit IV
  • Cytochrome b-c1 complex subunit 4
  • Cytochrome c-1
  • Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Gene NameCYC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020718|Cytochrome c1, heme protein, mitochondrial
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVM
LSALGMLAAGGAGLAMALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQV
CASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYP
NSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQ
AIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLV
PLVYTIKRHKWSVLKSRKLAYRPPK
Number of residues325
Molecular Weight35421.61
Theoretical pI9.25
GO Classification
Functions
  • metal ion binding
  • electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
  • heme binding
Processes
  • small molecule metabolic process
  • cellular metabolic process
  • respiratory electron transport chain
  • response to glucagon
Components
  • mitochondrial inner membrane
  • integral component of membrane
  • respiratory chain
  • mitochondrion
  • membrane
  • nucleus
General FunctionMetal ion binding
Specific FunctionThis is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.
Pfam Domain Function
Transmembrane Regions292-306
GenBank Protein ID181238
UniProtKB IDP08574
UniProtKB Entry NameCY1_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0020719|Cytochrome c1, heme protein, mitochondrial (CYC1)
ATGGCGGCAGCTGCGGCTTCGCTTCGCGGGGTAGTGTTGGGCCCGCGGGGCGCGGGGCTC
CCGGGCGCGCGTGCCCGGGGTCTGCTGTGCAGCGCGCGTCCCGGGCAGCTCCCGCTACGG
ACACCTCAGGCAGTGGCCTTGTCGTCGAAGTCTGGCCTTTCCCGAGGCCGGAAAGTGATG
CTGTCAGCGCTGGGCATGCTGGCGGCAGGGGGTGCGGGGCTGGCCGTGGCTCTGCATTCG
GCTGTGAGTGCCAGTGACCTGGAGCTGCACCCCCCCAGCTATCCGTGGTCTCACCGTGGC
CTCCTCTCTTCCTTGGACCACACCAGCATCCGGAGGGGTTTCCAGGTATATAAGCAGGTG
TGCGCCTCCTGCCACAGCATGGACTTCGTGGCCTACCGCCACCTGGTGGGCGTGTGCTAC
ACGGAGGATGAAGCTAAGGAGCTGGCTGCGGAGGTGGAGGTTCAAGACGGCCCCAATGAA
GATGGGGAGATGTTCATGCGGCCAGGGAAGCTGTTCGACTATTTCCCAAAACCATACCCC
AACAGTGAGGCTGCTCGAGCTGCCAACAACGGAGCATTGCCCCCTGACCTCAGCTACATC
GTGCGAGCTAGGCATGGTGGTGAGGACTACGTCTTCTCCCTGCTCACGGGCTACTGCGAG
CCACCCACCGGGGTGTCACTGCGGGAAGGTCTCTACTTCAACCCCTACTTTCCTGGCCAG
GCCATTGCCATGGCCCCTCCCATCTACACAGATGTCTTAGAGTTTGACGATGGCACCCCA
GCTACCATGTCCCAGATAGCCAAGGATGTGTGCACCTTCCTGCGCTGGGCATCTGAGCCA
GAGCACGACCATCGAAAACGCATGGGGCTCAAGATGTTGATGATGATGGCTCTGCTGGTG
CCCCTGGTCTACACCATAAAGCGGCACAAGTGGTCAGTCCTGAAGAGTCGGAAGCTGGCA
TATCGGCCGCCCAAGTGA
GenBank Gene IDM16597
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2579
Chromosome Location8
Locus8q24.3
References
  1. Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T: Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. Nucleic Acids Res. 1988 Apr 25;16(8):3577. 2836796
  2. Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T: Structural organization of the human mitochondrial cytochrome c1 gene. J Biol Chem. 1989 Jan 25;264(3):1368-74. 2536365
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  5. Nishikimi M, Suzuki H, Ohta S, Sakurai T, Shimomura Y, Tanaka M, Kagawa Y, Ozawa T: Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library. Biochem Biophys Res Commun. 1987 May 29;145(1):34-9. 3036122
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  9. Valnot I, Kassis J, Chretien D, de Lonlay P, Parfait B, Munnich A, Kachaner J, Rustin P, Rotig A: A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. Hum Genet. 1999 Jun;104(6):460-6. 10453733
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