Neutrophil elastase

NameNeutrophil elastase
Synonyms
  • 3.4.21.37
  • Bone marrow serine protease
  • ELA2
  • Elastase-2
  • HLE
  • Human leukocyte elastase
  • Medullasin
  • PMN elastase
Gene NameELANE
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000785|Neutrophil elastase
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Number of residues267
Molecular Weight28517.81
Theoretical pI9.41
GO Classification
Functions
  • endopeptidase activity
  • serine-type endopeptidase activity
  • protease binding
  • heparin binding
  • cytokine binding
  • RNA polymerase II transcription corepressor activity
  • peptidase activity
Processes
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of interleukin-8 biosynthetic process
  • cellular calcium ion homeostasis
  • protein catabolic process
  • positive regulation of MAP kinase activity
  • proteolysis
  • response to UV
  • positive regulation of smooth muscle cell proliferation
  • response to yeast
  • phagocytosis
  • acute inflammatory response to antigenic stimulus
  • collagen catabolic process
  • negative regulation of chemokine biosynthetic process
  • extracellular matrix disassembly
  • negative regulation of chemotaxis
  • extracellular matrix organization
  • negative regulation of growth of symbiont in host
  • leukocyte migration
  • negative regulation of interleukin-8 biosynthetic process
  • defense response to bacterium
  • neutrophil mediated killing of fungus
  • negative regulation of inflammatory response
  • response to lipopolysaccharide
  • positive regulation of immune response
Components
  • extracellular region
  • extracellular space
  • cell surface
  • transcriptional repressor complex
  • extracellular exosome
  • secretory granule
  • cytoplasm
General FunctionSerine-type endopeptidase activity
Specific FunctionModifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID296665
UniProtKB IDP08246
UniProtKB Entry NameELNE_HUMAN
Cellular LocationCytoplasmic
Gene sequence
>lcl|BSEQ0010273|Neutrophil elastase (ELANE)
ATGACCCTCGGCCGCCGACTCGCGTGTCTTTTCCTCGCCTGTGTCCTGCCGGCCTTGCTG
CTGGGGGGCACCGCGCTGGCCTCGGAGATTGTGGGGGGCCGGCGAGCGCGGCCCCACGCG
TGGCCCTTCATGGTGTCCCTGCAGCTGCGCGGAGGCCACTTCTGCGGCGCCACCCTGATT
GCGCCCAACTTCGTCATGTCGGCCGCGCACTGCGTGGCGAATGTAAACGTCCGCGCGGTG
CGGGTGGTCCTGGGAGCCCATAACCTCTCGCGGCGGGAGCCCACCCGGCAGGTGTTCGCC
GTGCAGCGCATCTTCGAAAACGGCTACGACCCCGTAAACTTGCTCAACGACATCGTGATT
CTCCAGCTCAACGGGTCGGCCACCATCAACGCCAACGTGCAGGTGGCCCAGCTGCCGGCT
CAGGGACGCCGCCTGGGCAACGGGGTGCAGTGCCTGGCCATGGGCTGGGGCCTTCTGGGC
AGGAACCGTGGGATCGCCAGCGTCCTGCAGGAGCTCAACGTGACGGTGGTGACGTCCCTC
TGCCGTCGCAGCAACGTCTGCACTCTCGTGAGGGGCCGGCAGGCCGGCGTCTGTTTCGGG
GACTCCGGCAGCCCCTTGGTCTGCAACGGGCTAATCCACGGAATTGCCTCCTTCGTCCGG
GGAGGCTGCGCCTCAGGGCTCTACCCCGATGCCTTTGCCCCGGTGGCACAGTTTGTAAAC
TGGATCGACTCTATCATCCAACGCTCCGAGGACAACCCCTGTCCCCACCCCCGGGACCCG
GACCCGGCCAGCAGGACCCACTGA
GenBank Gene IDY00477
GeneCard IDNot Available
GenAtlas IDELA2
HGNC IDHGNC:3309
Chromosome Location19
Locus19p13.3
References
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