Tyrosine-protein kinase Lyn

NameTyrosine-protein kinase Lyn
Synonyms
  • 2.7.10.2
  • JTK8
  • Lck/Yes-related novel protein tyrosine kinase
  • p53Lyn
  • p56Lyn
  • V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Gene NameLYN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008201|Tyrosine-protein kinase Lyn
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Number of residues512
Molecular Weight58573.595
Theoretical pI7.13
GO Classification
Functions
  • receptor binding
  • non-membrane spanning protein tyrosine kinase activity
  • enzyme binding
  • receptor signaling protein tyrosine kinase activity
  • ion channel binding
  • glycosphingolipid binding
  • protein tyrosine kinase activity
  • ATP binding
Processes
  • B cell receptor signaling pathway
  • negative regulation of mast cell proliferation
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • ephrin receptor signaling pathway
  • regulation of mast cell activation
  • positive regulation of B cell receptor signaling pathway
  • negative regulation of myeloid leukocyte differentiation
  • innate immune response
  • positive regulation of neuron projection development
  • negative regulation of B cell proliferation
  • response to drug
  • cellular response to heat
  • positive regulation of dendritic cell apoptotic process
  • peptidyl-tyrosine autophosphorylation
  • negative regulation of toll-like receptor 2 signaling pathway
  • response to toxic substance
  • positive regulation of mast cell proliferation
  • negative regulation of immune response
  • positive regulation of Fc receptor mediated stimulatory signaling pathway
  • peptidyl-tyrosine phosphorylation
  • negative regulation of toll-like receptor 4 signaling pathway
  • response to insulin
  • negative regulation of protein phosphorylation
  • positive regulation of oligodendrocyte progenitor proliferation
  • Fc-epsilon receptor signaling pathway
  • regulation of mast cell degranulation
  • neuron projection development
  • regulation of cytokine production
  • positive regulation of stress-activated protein kinase signaling cascade
  • cellular response to retinoic acid
  • viral process
  • regulation of B cell receptor signaling pathway
  • platelet activation
  • lipopolysaccharide-mediated signaling pathway
  • B cell homeostasis
  • positive regulation of tyrosine phosphorylation of STAT protein
  • leukocyte migration
  • positive regulation of cellular component movement
  • positive regulation of glial cell proliferation
  • regulation of B cell apoptotic process
  • positive regulation of cell migration
  • adaptive immune response
  • erythrocyte differentiation
  • positive regulation of phosphatidylinositol 3-kinase activity
  • cytokine secretion
  • regulation of monocyte chemotaxis
  • negative regulation of cell proliferation
  • response to organic cyclic compound
  • regulation of cell adhesion mediated by integrin
  • protein autophosphorylation
  • regulation of platelet aggregation
  • response to sterol depletion
  • protein phosphorylation
  • regulation of ERK1 and ERK2 cascade
  • regulation of protein phosphorylation
  • response to axon injury
  • tolerance induction to self antigen
  • stimulatory C-type lectin receptor signaling pathway
  • negative regulation of MAP kinase activity
  • immune response-regulating cell surface receptor signaling pathway
  • response to amino acid
  • regulation of erythrocyte differentiation
  • platelet degranulation
  • response to carbohydrate
  • negative regulation of intracellular signal transduction
  • cellular response to extracellular stimulus
  • dendritic cell differentiation
  • signal transduction
  • positive regulation of cell proliferation
  • negative regulation of ERK1 and ERK2 cascade
  • regulation of cytokine secretion
  • T cell costimulation
  • signal transduction by protein phosphorylation
  • Fc receptor mediated stimulatory signaling pathway
  • cellular response to peptide hormone stimulus
  • Fc receptor mediated inhibitory signaling pathway
  • axon guidance
  • response to hormone
  • oligodendrocyte development
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • histamine secretion by mast cell
  • cellular response to DNA damage stimulus
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • blood coagulation
  • regulation of inflammatory response
  • regulation of release of sequestered calcium ion into cytosol
Components
  • nucleus
  • membrane raft
  • postsynaptic density
  • plasma membrane
  • mast cell granule
  • Golgi apparatus
  • cytosol
  • extracellular exosome
  • extrinsic component of cytoplasmic side of plasma membrane
  • cytoplasm
  • perinuclear region of cytoplasm
  • integrin alpha2-beta1 complex
  • mitochondrial intermembrane space
  • cell-cell adherens junction
  • mitochondrial crista
General FunctionReceptor signaling protein tyrosine kinase activity
Specific FunctionNon-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID307144
UniProtKB IDP07948
UniProtKB Entry NameLYN_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017409|Tyrosine-protein kinase Lyn (LYN)
ATGGGATGTATAAAATCAAAAGGGAAAGACAGCTTGAGTGACGATGGAGTAGATTTGAAG
ACTCAACCAGTTCCAGAATCTCAGCTTTTACCTGGACAGAGGTTTCAAACTAAAGATCCA
GAGGAACAAGGAGACATTGTGGTAGCCTTGTACCCCTATGATGGCATCCACCCGGACGAC
TTGTCTTTCAAGAAAGGAGAGAAGATGAAAGTCCTGGAGGAGCATGGAGAATGGTGGAAA
GCAAAGTCCCTTTTAACAAAAAAAGAAGGCTTCATCCCCAGCAACTATGTGGCCAAACTC
AACACCTTAGAAACAGAAGAGTGGTTTTTCAAGGATATAACCAGGAAGGACGCAGAAAGG
CAGCTTTTGGCACCAGGAAATAGCGCTGGAGCTTTCCTTATTAGAGAAAGTGAAACATTA
AAAGGAAGCTTCTCTCTGTCTGTCAGAGACTTTGACCCTGTGCATGGTGATGTTATTAAG
CACTACAAAATTAGAAGTCTGGATAATGGGGGCTATTACATCTCTCCACGAATCACTTTT
CCCTGTATCAGCGACATGATTAAACATTACCAAAAGCAGGCAGATGGCTTGTGCAGAAGA
TTGGAGAAGGCTTGTATTAGTCCCAAGCCACAGAAGCCATGGGATAAAGATGCCTGGGAG
ATCCCCCGGGAGTCCATCAAGTTGGTGAAAAGGCTTGGCGCTGGGCAGTTTGGGGAAGTC
TGGATGGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGAAGCCAGGAACT
ATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAG
CTCGTGAGGCTCTACGCTGTGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTAC
ATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCAAAGTGCTGCTT
CCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAG
AACTACATTCACCGGGACCTGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGC
AAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACACAGCAAGGGAA
GGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACT
ATTAAGTCTGATGTGTGGTCCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAA
ATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCAGGGCTACAGG
ATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAA
GAAAAGGCAGAAGAGAGACCAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTAC
ACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAG
GenBank Gene IDM16038
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6735
Chromosome Location8
Locus8q13
References
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