NameCathepsin B
Synonyms
  • 3.4.22.1
  • APP secretase
  • APPS
  • Cathepsin B1
  • CPSB
Gene NameCTSB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019038|Cathepsin B
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Number of residues339
Molecular Weight37821.35
Theoretical pI6.27
GO Classification
Functions
  • collagen binding
  • peptidase activity
  • cysteine-type endopeptidase activity
  • peptide binding
  • cysteine-type peptidase activity
  • proteoglycan binding
Processes
  • cellular response to mechanical stimulus
  • spermatogenesis
  • collagen catabolic process
  • decidualization
  • extracellular matrix disassembly
  • proteolysis
  • response to organic cyclic compound
  • extracellular matrix organization
  • skeletal muscle tissue development
  • response to peptide hormone
  • epithelial cell differentiation
  • response to wounding
  • negative regulation of cell death
  • toll-like receptor signaling pathway
  • regulation of apoptotic process
  • cellular response to thyroid hormone stimulus
  • proteolysis involved in cellular protein catabolic process
  • response to ethanol
  • regulation of catalytic activity
  • response to amine
  • autophagy
  • response to interleukin-4
  • viral entry into host cell
  • innate immune response
  • response to glucose
Components
  • intracellular
  • mitochondrion
  • extracellular region
  • intracellular membrane-bounded organelle
  • extracellular space
  • apical plasma membrane
  • lysosome
  • endolysosome lumen
  • caveola
  • sarcolemma
  • extracellular exosome
  • melanosome
  • nucleolus
  • perinuclear region of cytoplasm
  • external side of plasma membrane
General FunctionProteoglycan binding
Specific FunctionThiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181192
UniProtKB IDP07858
UniProtKB Entry NameCATB_HUMAN
Cellular LocationLysosome
Gene sequence
>lcl|BSEQ0019039|Cathepsin B (CTSB)
ATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGG
CCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACG
TGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGT
ACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATGTTTACCGAGGACCTGAAGCTG
CCTGCAAGCTTCGATGCACGGGAACAATGGCCACAGTGTCCCACCATCAAAGAGATCAGA
GACCAGGGCTCCTGTGGCTCCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGG
ATCTGCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCACA
TGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCCTGCTGAAGCTTGGAAC
TTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTATGAATCCCATGTAGGGTGCAGA
CCGTACTCCATCCCTCCCTGTGAGCACCACGTCAACGGCTCCCGGCCCCCATGCACGGGG
GAGGGAGATACCCCCAAGTGTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAA
CAGGACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATG
GCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTG
CTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATC
CGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGG
AACACTGACTGGGGTGACAATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGA
ATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAA
GenBank Gene IDM14221
GeneCard IDNot Available
GenAtlas IDCTSB
HGNC IDHGNC:2527
Chromosome Location8
Locus8p22
References
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