NameCarbonic anhydrase 3
Synonyms
  • 4.2.1.1
  • CA-III
  • Carbonate dehydratase III
  • Carbonic anhydrase III
Gene NameCA3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012519|Carbonic anhydrase 3
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
Number of residues260
Molecular Weight29557.215
Theoretical pI7.38
GO Classification
Functions
  • nickel cation binding
  • phosphatase activity
  • zinc ion binding
  • carbonate dehydratase activity
Processes
  • response to oxidative stress
  • small molecule metabolic process
  • response to ethanol
  • bicarbonate transport
  • one-carbon metabolic process
Components
  • cytosol
General FunctionZinc ion binding
Specific FunctionReversible hydration of carbon dioxide.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID189053812
UniProtKB IDP07451
UniProtKB Entry NameCAH3_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012520|Carbonic anhydrase 3 (CA3)
ATGGCCAAGGAGTGGGGCTACGCCAGTCACAACGGTCCTGACCACTGGCATGAACTTTTC
CCAAATGCCAAGGGGGAAAACCAGTCGCCCGTTGAGCTGCATACTAAAGACATCAGGCAT
GACCCTTCTCTGCAGCCATGGTCTGTGTCTTATGATGGTGGCTCTGCCAAGACCATCCTG
AATAATGGGAAGACCTGCCGAGTTGTATTTGATGATACTTATGATAGGTCAATGCTGAGA
GGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGTTTCATCTTCACTGGGGCTCTTCG
GATGATCATGGCTCTGAGCACACCGTGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTG
GTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGGATC
GCTGTGATTGGCATTTTTCTGAAGATAGGACATGAGAATGGCGAGTTCCAGATTTTCCTT
GATGCATTGGACAAGATTAAGACAAAGGGCAAGGAGGCGCCCTTCACAAAGTTTGACCCA
TCCTGCCTGTTCCCGGCATGCCGGGACTACTGGACCTACCAGGGCTCATTCACCACGCCG
CCCTGCGAGGAATGCATTGTGTGGCTGCTGCTGAAGGAGCCCATGACCGTGAGCTCTGAC
CAGATGGCCAAGCTGCGGAGCCTCCTCTCCAGTGCTGAGAACGAGCCCCCAGTGCCTCTT
GTGAGCAACTGGCGACCTCCACAGCCTATCAATAACAGGGTGGTGAGAGCTTCCTTCAAA
TGA
GenBank Gene IDAK313254
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:1374
Chromosome Location8
Locus8q13-q22
References
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  2. Wade R, Gunning P, Eddy R, Shows T, Kedes L: Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes. Proc Natl Acad Sci U S A. 1986 Dec;83(24):9571-5. 3099285
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