Eukaryotic translation initiation factor 4E

NameEukaryotic translation initiation factor 4E
Synonyms
  • eIF-4E
  • eIF-4F 25 kDa subunit
  • EIF4EL1
  • EIF4F
  • mRNA cap-binding protein
Gene NameEIF4E
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001905|Eukaryotic translation initiation factor 4E
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Number of residues217
Molecular Weight25097.07
Theoretical pI6.04
GO Classification
Functions
  • RNA cap binding
  • poly(A) RNA binding
  • translation initiation factor activity
  • enzyme binding
  • eukaryotic initiation factor 4G binding
  • repressing transcription factor binding
Processes
  • cytokine-mediated signaling pathway
  • positive regulation of mitotic cell cycle
  • mRNA export from nucleus
  • G1/S transition of mitotic cell cycle
  • negative regulation of neuron differentiation
  • stem cell population maintenance
  • negative regulation of translation
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • viral process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • behavioral fear response
  • regulation of translation
  • translation
  • translational initiation
  • gene expression
  • cellular protein metabolic process
  • insulin receptor signaling pathway
Components
  • cytoplasm
  • chromatoid body
  • cytoplasmic mRNA processing body
  • cytoplasmic stress granule
  • eukaryotic translation initiation factor 4F complex
  • cytosol
  • mRNA cap binding complex
  • extracellular exosome
  • RISC complex
  • perinuclear region of cytoplasm
General FunctionTranslation initiation factor activity
Specific FunctionRecognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID306487
UniProtKB IDP06730
UniProtKB Entry NameIF4E_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010673|Eukaryotic translation initiation factor 4E (EIF4E)
ATGTTGGACCTGACCTCCCGCGGACAAGTGGGGACGTCCCGGAGGATGGCCGAGGCGGCG
TGTAGCGCACACTTTCTGGAAACCACCCCTACTCCTAATCCCCCGACTACAGAAGAGGAG
AAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAG
AACAGATGGGCACTCTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTG
CGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGCTCTGTACAACCATATCCAG
TTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCT
ATGTGGGAAGATGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAG
CAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACACTTCTGTGCCTTATTGGAGAA
TCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGT
GATAAGATAGCAATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGG
AGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGATAGTGATTGGTTATCAGTCCCAC
GCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAA
GenBank Gene IDM15353
GeneCard IDNot Available
GenAtlas IDEIF4E
HGNC IDHGNC:3287
Chromosome Location4
Locus4q21-q25
References
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