Tyrosine-protein kinase Fyn

NameTyrosine-protein kinase Fyn
Synonyms
  • 2.7.10.2
  • p59-Fyn
  • Proto-oncogene c-Fyn
  • Proto-oncogene Syn
  • SLK
  • Src-like kinase
Gene NameFYN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037856|Tyrosine-protein kinase Fyn
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Number of residues537
Molecular Weight60761.49
Theoretical pI6.65
GO Classification
Functions
  • ephrin receptor binding
  • ATP binding
  • glycoprotein binding
  • growth factor receptor binding
  • metal ion binding
  • non-membrane spanning protein tyrosine kinase activity
  • protein tyrosine kinase activity
Processes
  • neurotrophin TRK receptor signaling pathway
  • axon guidance
  • T cell activation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • protein phosphorylation
  • cell differentiation
  • T cell costimulation
  • blood coagulation
  • Ras protein signal transduction
  • cell migration
  • T cell receptor signaling pathway
  • stimulatory C-type lectin receptor signaling pathway
  • activated T cell proliferation
  • epidermal growth factor receptor signaling pathway
  • negative regulation of neuron apoptotic process
  • response to drug
  • vascular endothelial growth factor receptor signaling pathway
  • cellular response to peptide hormone stimulus
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • forebrain development
  • positive regulation of phosphatidylinositol 3-kinase signaling
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • innate immune response
  • small GTPase mediated signal transduction
  • intracellular signal transduction
  • positive regulation of protein localization to nucleus
  • peptidyl-tyrosine autophosphorylation
  • ephrin receptor signaling pathway
  • dendrite morphogenesis
  • regulation of defense response to virus by virus
  • peptidyl-tyrosine phosphorylation
  • positive regulation of neuron projection development
  • regulation of cell shape
  • regulation of cell proliferation
  • negative regulation of protein ubiquitination
  • Fc-epsilon receptor signaling pathway
  • viral process
  • feeding behavior
  • platelet activation
  • positive regulation of tyrosine phosphorylation of Stat5 protein
  • cellular response to transforming growth factor beta stimulus
  • neuron migration
  • learning
  • leukocyte migration
  • detection of mechanical stimulus involved in sensory perception of pain
  • regulation of apoptotic process
  • cellular response to platelet-derived growth factor stimulus
  • activation of MAPKK activity
  • adaptive immune response
  • phosphatidylinositol-mediated signaling
  • fibroblast growth factor receptor signaling pathway
  • insulin receptor signaling pathway
  • negative regulation of protein catabolic process
  • response to ethanol
  • MAPK cascade
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • negative regulation of gene expression
  • calcium ion transport
Components
  • nucleus
  • plasma membrane
  • endosome
  • postsynaptic density
  • actin filament
  • cytosol
  • extrinsic component of cytoplasmic side of plasma membrane
  • mitochondrion
General FunctionProtein tyrosine kinase activity
Specific FunctionNon-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID338228
UniProtKB IDP06241
UniProtKB Entry NameFYN_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010591|Tyrosine-protein kinase Fyn (FYN)
ATGGGCTGTGTGCAATGTAAGGATAAAGAAGCAACAAAACTGACGGAGGAGAGGGACGGC
AGCCTGAACCAGAGCTCTGGGTACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCC
AGCTTCGGTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGA
CTCACCGTCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGACCTTGCGTACGAGAGGA
GGAACAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATGAC
CTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGG
GAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCA
GTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAG
CGACAGCTATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACC
ACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTC
AAACATTATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAG
TTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGAGAGAGCTGCAGGTCTCTGCTGC
CGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACC
AAAGATGTCTGGGAAATCCCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGG
CAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGACT
CTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAG
CTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGTGTCTGAGGAGCCCATCTACATC
GTCACCGAGTATATGAACAAAGGAAGTTTACTGGATTTCTTAAAAGATGGAGAAGGAAGA
GCTCTGAAATTACCAAATCTTGTGGACATGGCAGCACAGGTGGCTGCAGGAATGGCTTAC
ATCGAGCGCATGAATTATATCCATAGAGATCTGCGATCAGCAAACATTCTAGTGGGGAAT
GGACTCATATGCAAGATTGCTGACTTCGGATTGGCCCGATTGATAGAAGACAATGAGTAC
ACAGCAAGACAAGGTGCAAAGTTCCCCATCAAGTGGACGGCCCCCGAGGCAGCCCTGTAC
GGGAGGTTCACAATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTC
ACCAAAGGAAGAGTGCCATACCCAGGCATGAACAACCGGGAGGTGCTGGAGCAGGTGGAG
CGAGGCTACAGGATGCCCTGCCCGCAGGACTGCCCCATCTCTCTGCATGAGCTCATGATC
CACTGCTGGAAAAAGGACCCTGAAGAACGCCCCACTTTTGAGTACTTGCAGAGCTTCCTG
GAAGACTACTTTACCGCGACAGAGCCCCAGTACCAACCTGGTGAAAACCTGTAA
GenBank Gene IDM14333
GeneCard IDNot Available
GenAtlas IDFYN
HGNC IDHGNC:4037
Chromosome Location6
Locus6q21
References
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