Transcription factor AP-1

NameTranscription factor AP-1
Synonyms
  • Activator protein 1
  • AP1
  • p39
  • Proto-oncogene c-Jun
  • V-jun avian sarcoma virus 17 oncogene homolog
Gene NameJUN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016292|Transcription factor AP-1
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Number of residues331
Molecular Weight35675.32
Theoretical pI9.11
GO Classification
Functions
  • RNA polymerase II activating transcription factor binding
  • transcription regulatory region DNA binding
  • cAMP response element binding
  • chromatin binding
  • transcription factor binding
  • transcription factor activity, sequence-specific DNA binding
  • enzyme binding
  • poly(A) RNA binding
  • GTPase activator activity
  • transcription coactivator activity
  • RNA polymerase II distal enhancer sequence-specific DNA binding
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • transcriptional activator activity, RNA polymerase II transcription factor binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • DNA binding
  • R-SMAD binding
Processes
  • regulation of sequence-specific DNA binding transcription factor activity
  • negative regulation of DNA binding
  • response to drug
  • aging
  • negative regulation of cell proliferation
  • positive regulation of transcription from RNA polymerase II promoter
  • stress-activated MAPK cascade
  • regulation of cell cycle
  • positive regulation of endothelial cell proliferation
  • response to muscle stretch
  • toll-like receptor 10 signaling pathway
  • response to cytokine
  • positive regulation of DNA-templated transcription, initiation
  • circadian rhythm
  • toll-like receptor 2 signaling pathway
  • leading edge cell differentiation
  • negative regulation of neuron apoptotic process
  • release of cytochrome c from mitochondria
  • cellular response to hormone stimulus
  • toll-like receptor 3 signaling pathway
  • microglial cell activation
  • response to radiation
  • positive regulation of cell differentiation
  • response to lipopolysaccharide
  • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • positive regulation of monocyte differentiation
  • positive regulation of GTPase activity
  • toll-like receptor 4 signaling pathway
  • positive regulation by host of viral transcription
  • negative regulation of transcription, DNA-templated
  • positive regulation of fibroblast proliferation
  • angiogenesis
  • toll-like receptor 5 signaling pathway
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter
  • cellular response to potassium ion starvation
  • positive regulation of DNA replication
  • toll-like receptor 9 signaling pathway
  • regulation of cell death
  • learning
  • toll-like receptor signaling pathway
  • axon regeneration
  • negative regulation by host of viral transcription
  • cellular response to calcium ion
  • toll-like receptor TLR1
  • innate immune response
  • outflow tract morphogenesis
  • membrane depolarization
  • toll-like receptor TLR6
  • regulation of cell proliferation
  • positive regulation of smooth muscle cell proliferation
  • TRIF-dependent toll-like receptor signaling pathway
  • Fc-epsilon receptor signaling pathway
  • positive regulation of neuron apoptotic process
  • monocyte differentiation
  • negative regulation of protein autophosphorylation
  • response to mechanical stimulus
  • positive regulation of transcription, DNA-templated
  • MyD88-dependent toll-like receptor signaling pathway
  • SMAD protein signal transduction
  • liver development
  • response to cAMP
  • MyD88-independent toll-like receptor signaling pathway
  • SMAD protein import into nucleus
  • transforming growth factor beta receptor signaling pathway
  • response to hydrogen peroxide
Components
  • nuclear chromosome
  • cytosol
  • transcriptional repressor complex
  • nucleoplasm
  • nuclear euchromatin
  • transcription factor complex
  • nucleus
General FunctionTranscriptional activator activity, rna polymerase ii transcription factor binding
Specific FunctionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID386839
UniProtKB IDP05412
UniProtKB Entry NameJUN_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016293|Transcription factor AP-1 (JUN)
ATGACTGCAAAGATGGAAACGACCTTCTATGACGATGCCCTCAACGCCTCGTTCCTCCCG
TCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTGAAACAGAGCATGACCCTG
AACCTGGCCGACCCAGTGGGGAGCCTGAAGCCGCACCTCCGCGCCAAGAACTCGGACCTC
CTCACCTCGCCCGACGTGGGGCTGCTCAAGCTGGCGTCGCCCGAGCTGGAGCGCCTGATA
ATCCAGTCCAGCAACGGGCACATCACCACCACGCCGACCCCCACCCAGTTCCTGTGCCCC
AAGAACGTGACAGATGAGCAGGAGGGCTTCGCCGAGGGCTTCGTGCGCGCCCTGGCCGAA
CTGCACAGCCAGAACACGCTGCCCAGCGTCACGTCGGCGGCGCAGCCGGTCAACGGGGCA
GGCATGGTGGCTCCCGCGGTAGCCTCGGTGGCAGGGGGCAGCGGCAGCGGCGGCTTCAGC
GCCAGCCTGCACAGCGAGCCGCCGGTCTACGCAAACCTCAGCAACTTCAACCCAGGCGCG
CTGAGCAGCGGCGGCGGGGCGCCCTCCTACGGCGCGGCCGGCCTGGCCTTTCCCGCGCAA
CCCCAGCAGCAGCAGCAGCCGCCGCACCACCTGCCCCAGCAGATGCCCGTGCAGCACCCG
CGGCTGCAGGCCCTGAAGGAGGAGCCTCAGACAGTGCCCGAGATGCCCGGCGAGACACCG
CCCCTGTCCCCCATCGACATGGAGTCCCAGGAGCGGATCAAGGCGGAGAGGAAGCGCATG
AGGAACCGCATCGCTGCCTCCAAGTGCCGAAAAAGGAAGCTGGAGAGAATCGCCCGGCTG
GAGGAAAAAGTGAAAACCTTGAAAGCTCAGAACTCGGAGCTGGCGTCCACGGCCAACATG
CTCAGGGAACAGGTGGCACAGCTTAAACAGAAAGTCATGAACCACGTTAACAGTGGGTGC
CAACTCATGCTAACGCAGCAGTTGCAAACATTTTGA
GenBank Gene IDJ04111
GeneCard IDNot Available
GenAtlas IDJUN
HGNC IDHGNC:6204
Chromosome Location1
Locus1p32-p31
References
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