Interleukin-6

NameInterleukin-6
Synonyms
  • B-cell stimulatory factor 2
  • BSF-2
  • CDF
  • CTL differentiation factor
  • Hybridoma growth factor
  • IFN-beta-2
  • IFNB2
  • IL-6
  • Interferon beta-2
Gene NameIL6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021838|Interleukin-6
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Number of residues212
Molecular Weight23717.965
Theoretical pI6.52
GO Classification
Functions
  • interleukin-6 receptor binding
  • growth factor activity
  • cytokine activity
Processes
  • response to auditory stimulus
  • humoral immune response
  • regulation of circadian sleep/wake cycle, non-REM sleep
  • positive regulation of ERK1 and ERK2 cascade
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of peptidyl-serine phosphorylation
  • positive regulation of protein import into nucleus, translocation
  • inflammatory response
  • muscle cell cellular homeostasis
  • positive regulation of smooth muscle cell proliferation
  • monocyte chemotaxis
  • endocrine pancreas development
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of gluconeogenesis
  • defense response to Gram-positive bacterium
  • positive regulation of neuron differentiation
  • response to heat
  • acute-phase response
  • positive regulation of T-helper 2 cell differentiation
  • cell growth
  • defense response to virus
  • response to amino acid
  • positive regulation of tyrosine phosphorylation of Stat3 protein
  • positive regulation of cell proliferation
  • response to peptidoglycan
  • regulation of cell shape
  • positive regulation of JAK-STAT cascade
  • regulation of angiogenesis
  • response to cold
  • positive regulation of interleukin-6 production
  • negative regulation of fat cell differentiation
  • platelet activation
  • defense response to protozoan
  • defense response to Gram-negative bacterium
  • positive regulation of protein kinase B signaling
  • response to calcium ion
  • neutrophil mediated immunity
  • cell redox homeostasis
  • cellular response to interleukin-1
  • positive regulation of chemokine production
  • positive regulation of immunoglobulin secretion
  • response to glucocorticoid
  • interleukin-6-mediated signaling pathway
  • negative regulation of protein kinase activity
  • negative regulation of neuron death
  • positive regulation of T cell proliferation
  • positive regulation of transmission of nerve impulse
  • response to nutrient levels
  • glucose homeostasis
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • positive regulation of osteoblast differentiation
  • negative regulation of chemokine biosynthetic process
  • cellular response to lipopolysaccharide
  • hepatic immune response
  • positive regulation of apoptotic process
  • regulation of vascular endothelial growth factor production
  • aging
  • response to yeast
  • bone remodeling
  • negative regulation of collagen biosynthetic process
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of STAT protein import into nucleus
  • cellular response to dexamethasone stimulus
  • response to drug
  • positive regulation of translation
  • cytokine-mediated signaling pathway
  • glucagon secretion
  • positive regulation of leukocyte chemotaxis
  • cellular response to hydrogen peroxide
  • response to antibiotic
  • positive regulation of nitric oxide biosynthetic process
  • positive regulation of DNA replication
  • negative regulation of muscle organ development
  • cellular response to tumor necrosis factor
  • positive regulation of acute inflammatory response
  • response to electrical stimulus
  • response to caffeine
  • neutrophil apoptotic process
  • response to insulin
  • positive regulation of type B pancreatic cell apoptotic process
  • positive regulation of transcription, DNA-templated
  • positive regulation of B cell activation
  • negative regulation of cytokine secretion
  • negative regulation of hormone secretion
  • branching involved in salivary gland morphogenesis
  • neuron projection development
  • T-helper 17 cell lineage commitment
  • negative regulation of apoptotic process
  • negative regulation of lipid storage
  • positive regulation of MAPK cascade
  • epithelial cell proliferation involved in salivary gland morphogenesis
  • positive regulation of epithelial cell proliferation
  • negative regulation of cell proliferation
Components
  • interleukin-6 receptor complex
  • cytoplasm
  • extracellular region
  • external side of plasma membrane
  • extracellular space
General FunctionInterleukin-6 receptor binding
Specific FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID32674
UniProtKB IDP05231
UniProtKB Entry NameIL6_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021839|Interleukin-6 (IL6)
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTGCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG
GenBank Gene IDX04430
GeneCard IDNot Available
GenAtlas IDIL6
HGNC IDHGNC:6018
Chromosome Location7
Locus7p21
References
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