NameADP/ATP translocase 2
Synonyms
  • Adenine nucleotide translocator 2
  • ADP,ATP carrier protein 2
  • ADP,ATP carrier protein, fibroblast isoform
  • ANT 2
  • ANT2
  • Solute carrier family 25 member 5
Gene NameSLC25A5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010497|ADP/ATP translocase 2
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR
IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVS
VQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMM
QSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
Number of residues298
Molecular Weight32851.965
Theoretical pI10.23
GO Classification
Functions
  • ubiquitin protein ligase binding
  • poly(A) RNA binding
  • adenine transmembrane transporter activity
Processes
  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  • small molecule metabolic process
  • energy reserve metabolic process
  • regulation of insulin secretion
  • positive regulation of cell proliferation
  • viral process
  • chromosome segregation
  • transport
  • adenine transport
Components
  • MMXD complex
  • nucleus
  • mitochondrial inner membrane
  • extracellular exosome
  • myelin sheath
  • integral component of plasma membrane
  • mitochondrial nucleoid
  • mitochondrion
  • membrane
General FunctionUbiquitin protein ligase binding
Specific FunctionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Pfam Domain Function
Transmembrane Regions5-39 75-100 109-143 176-202 207-241 273-298
GenBank Protein ID178661
UniProtKB IDP05141
UniProtKB Entry NameADT2_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010498|ADP/ATP translocase 2 (SLC25A5)
ATGACAGATGCCGCTGTGTCCTTCGCCAAGGACTTCCTGGCAGGTGGAGTGGCCGCAGCC
ATCTCCAAGACGGCGGTAGCGCCCATCGAGCGGGTCAAGCTGCTGCTGCAGGTGCAGCAT
GCCAGCAAGCAGATCACTGCAGATAAGCAATACAAAGGCATTATAGACTGCGTGGTCCGT
ATTCCCAAGGAGCAGGGAGTTCTGTCCTTCTGGCGCGGTAACCTGGCCAATGTCATCAGA
TACTTCCCCACCCAGGCTCTTAACTTCGCCTTCAAAGATAAATACAAGCAGATCTTCCTG
GGTGGTGTGGACAAGAGAACCCAGTTTTGGCTCTACTTTGCAGGGAATCTGGCATCGGGT
GGTGCCGCAGGGGCCACATCCCTGTGTTTTGTGTACCCTCTTGATTTTGCCCGTACCCGT
CTAGCAGCTGATGTGGGTAAAGCTGGAGCTGAAAGGGAATTCCGAGGCCTCGGTGACTGC
CTGGTTAAGATCTACAAATCTGATGGGATTAAGGGCCTGTACCAAGGCTTTAACGTGTCT
GTGCAGGGTATTATCATCTACCGAGCCGCCTACTTCGGTATCTATGACACTGCAAAGGGA
ATGCTTCCGGATCCCAAGAACACTCACATCGTCATCAGCTGGATGATCGCACAGACTGTC
ACTGCTGTTGCCGGGTTGACTTCCTATCCATTTGACACTGTTCGCCGCCGCATGATGATG
CAGTCAGGGCGCAAAGGAACTGACATCATGTACACAGGCACGCTTGACTGCTGGCGGAAG
ATTGCTCGTGATGAAGGAGGCAAAGCTTTTTTCAAGGGTGCATGGTCCAATGTTCTCAGA
GGCATGGGTGGTGCTTTTGTGCTTGTCTTGTATGATGAAATCAAGAAGTACACATAA
GenBank Gene IDM57424
GeneCard IDNot Available
GenAtlas IDSLC25A5
HGNC IDHGNC:10991
Chromosome LocationX
LocusXq24-q26
References
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