NameADP/ATP translocase 2
Synonyms
  • Adenine nucleotide translocator 2
  • ADP,ATP carrier protein 2
  • ADP,ATP carrier protein, fibroblast isoform
  • ANT 2
  • ANT2
  • Solute carrier family 25 member 5
Gene NameSLC25A5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010497|ADP/ATP translocase 2
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR
IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVS
VQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMM
QSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
Number of residues298
Molecular Weight32851.965
Theoretical pI10.23
GO Classification
Functions
  • ubiquitin protein ligase binding
  • poly(A) RNA binding
  • adenine transmembrane transporter activity
Processes
  • positive regulation of cell proliferation
  • viral process
  • chromosome segregation
  • transport
  • adenine transport
  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  • small molecule metabolic process
  • energy reserve metabolic process
  • regulation of insulin secretion
Components
  • mitochondrial nucleoid
  • mitochondrion
  • membrane
  • MMXD complex
  • nucleus
  • mitochondrial inner membrane
  • extracellular exosome
  • myelin sheath
  • integral component of plasma membrane
General FunctionUbiquitin protein ligase binding
Specific FunctionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Pfam Domain Function
Transmembrane Regions5-39 75-100 109-143 176-202 207-241 273-298
GenBank Protein ID178661
UniProtKB IDP05141
UniProtKB Entry NameADT2_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010498|ADP/ATP translocase 2 (SLC25A5)
ATGACAGATGCCGCTGTGTCCTTCGCCAAGGACTTCCTGGCAGGTGGAGTGGCCGCAGCC
ATCTCCAAGACGGCGGTAGCGCCCATCGAGCGGGTCAAGCTGCTGCTGCAGGTGCAGCAT
GCCAGCAAGCAGATCACTGCAGATAAGCAATACAAAGGCATTATAGACTGCGTGGTCCGT
ATTCCCAAGGAGCAGGGAGTTCTGTCCTTCTGGCGCGGTAACCTGGCCAATGTCATCAGA
TACTTCCCCACCCAGGCTCTTAACTTCGCCTTCAAAGATAAATACAAGCAGATCTTCCTG
GGTGGTGTGGACAAGAGAACCCAGTTTTGGCTCTACTTTGCAGGGAATCTGGCATCGGGT
GGTGCCGCAGGGGCCACATCCCTGTGTTTTGTGTACCCTCTTGATTTTGCCCGTACCCGT
CTAGCAGCTGATGTGGGTAAAGCTGGAGCTGAAAGGGAATTCCGAGGCCTCGGTGACTGC
CTGGTTAAGATCTACAAATCTGATGGGATTAAGGGCCTGTACCAAGGCTTTAACGTGTCT
GTGCAGGGTATTATCATCTACCGAGCCGCCTACTTCGGTATCTATGACACTGCAAAGGGA
ATGCTTCCGGATCCCAAGAACACTCACATCGTCATCAGCTGGATGATCGCACAGACTGTC
ACTGCTGTTGCCGGGTTGACTTCCTATCCATTTGACACTGTTCGCCGCCGCATGATGATG
CAGTCAGGGCGCAAAGGAACTGACATCATGTACACAGGCACGCTTGACTGCTGGCGGAAG
ATTGCTCGTGATGAAGGAGGCAAAGCTTTTTTCAAGGGTGCATGGTCCAATGTTCTCAGA
GGCATGGGTGGTGCTTTTGTGCTTGTCTTGTATGATGAAATCAAGAAGTACACATAA
GenBank Gene IDM57424
GeneCard IDNot Available
GenAtlas IDSLC25A5
HGNC IDHGNC:10991
Chromosome LocationX
LocusXq24-q26
References
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