Cholesterol side-chain cleavage enzyme, mitochondrial

NameCholesterol side-chain cleavage enzyme, mitochondrial
Synonyms
  • 1.14.15.6
  • Cholesterol desmolase
  • CYP11A
  • CYPXIA1
  • Cytochrome P450 11A1
  • Cytochrome P450(scc)
Gene NameCYP11A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006815|Cholesterol side-chain cleavage enzyme, mitochondrial
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
Number of residues521
Molecular Weight60101.87
Theoretical pI9.18
GO Classification
Functions
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
  • cholesterol monooxygenase (side-chain-cleaving) activity
  • cholesterol binding
  • iron ion binding
  • heme binding
Processes
  • response to salt stress
  • small molecule metabolic process
  • response to L-ascorbic acid
  • testosterone biosynthetic process
  • cerebellum development
  • cellular response to fibroblast growth factor stimulus
  • response to amino acid
  • cellular response to transforming growth factor beta stimulus
  • cellular response to follicle-stimulating hormone stimulus
  • maternal process involved in female pregnancy
  • cellular response to tumor necrosis factor
  • cellular response to cadmium ion
  • response to vitamin E
  • response to hydrogen peroxide
  • dibenzo-p-dioxin metabolic process
  • Leydig cell differentiation
  • oxidation-reduction process
  • phenol-containing compound metabolic process
  • cellular response to cAMP
  • steroid metabolic process
  • C21-steroid hormone biosynthetic process
  • glucocorticoid biosynthetic process
  • sterol metabolic process
  • biphenyl metabolic process
  • vitamin D metabolic process
  • cortisol metabolic process
  • mating behavior
  • cellular response to lipopolysaccharide
  • granulosa cell differentiation
  • cellular response to antibiotic
  • cholesterol metabolic process
  • phthalate metabolic process
  • response to gamma radiation
  • Schwann cell differentiation
  • xenobiotic metabolic process
  • progesterone biosynthetic process
  • response to fungicide
  • cellular response to peptide hormone stimulus
  • secondary metabolite biosynthetic process
  • hippocampus development
  • response to genistein
  • response to drug
  • cellular response to interleukin-1
  • response to corticosterone
  • response to insecticide
  • response to alkaloid
  • estrogen biosynthetic process
Components
  • mitochondrial crista
  • perikaryon
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial matrix
General FunctionOxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific FunctionCatalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181376
UniProtKB IDP05108
UniProtKB Entry NameCP11A_HUMAN
Cellular LocationMitochondrion membrane
Gene sequence
>lcl|BSEQ0012463|Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTGCCAGACCTTTCTG
AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC
TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA
AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG
AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT
GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA
TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG
TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT
CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT
GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT
GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG
ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG
TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC
AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC
ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC
ATCCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC
ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT
GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG
CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC
ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT
GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT
GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG
CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG
CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG
GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT
CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG
CAGTGA
GenBank Gene IDM14565
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2590
Chromosome Location15
Locus15q23-q24
References
  1. Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL: Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proc Natl Acad Sci U S A. 1986 Dec;83(23):8962-6. 3024157
  2. Morohashi K, Sogawa K, Omura T, Fujii-Kuriyama Y: Gene structure of human cytochrome P-450(SCC), cholesterol desmolase. J Biochem. 1987 Apr;101(4):879-87. 3038854
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