Apolipoprotein D

NameApolipoprotein D
Synonyms
  • Apo-D
Gene NameAPOD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013437|Apolipoprotein D
MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGR
CIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWI
LATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVT
DQVNCPKLS
Number of residues189
Molecular Weight21275.37
Theoretical pINot Available
GO Classification
Functions
  • cholesterol binding
  • lipid transporter activity
Processes
  • negative regulation of monocyte chemotactic protein-1 production
  • glucose metabolic process
  • response to reactive oxygen species
  • negative regulation of protein import into nucleus
  • lipid metabolic process
  • negative regulation of cytokine production involved in inflammatory response
  • negative regulation of lipoprotein lipid oxidation
  • angiogenesis
  • negative regulation of T cell migration
  • peripheral nervous system axon regeneration
  • brain development
  • response to axon injury
  • negative regulation of smooth muscle cell-matrix adhesion
  • aging
  • response to drug
  • tissue regeneration
  • negative regulation of focal adhesion assembly
  • lipid transport
  • negative regulation of platelet-derived growth factor receptor signaling pathway
  • negative regulation of smooth muscle cell proliferation
Components
  • extracellular exosome
  • perinuclear region of cytoplasm
  • cytosolic ribosome
  • dendrite
  • neuronal cell body
  • extracellular region
  • endoplasmic reticulum
  • extracellular space
General FunctionLipid transporter activity
Specific FunctionAPOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP05090
UniProtKB Entry NameAPOD_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0013438|Apolipoprotein D (APOD)
ATGGTGATGCTGCTGCTGCTGCTTTCCGCACTGGCTGGCCTCTTCGGTGCGGCAGAGGGA
CAAGCATTTCATCTTGGGAAGTGCCCCAATCCTCCGGTGCAGGAGAATTTTGACGTGAAT
AAGTATCTCGGAAGATGGTACGAAATTGAGAAGATCCCAACAACCTTTGAGAATGGACGC
TGCATCCAGGCCAACTACTCACTAATGGAAAACGGAAAGATCAAAGTGTTAAACCAGGAG
TTGAGAGCTGATGGAACTGTGAATCAAATCGAAGGTGAAGCCACCCCAGTTAACCTCACA
GAGCCTGCCAAGCTGGAAGTTAAGTTTTCCTGGTTTATGCCATCGGCACCGTACTGGATC
CTGGCCACCGACTATGAGAACTATGCCCTCGTGTATTCCTGTACCTGCATCATCCAACTT
TTTCACGTGGATTTTGCTTGGATCTTGGCAAGAAACCCTAATCTCCCTCCAGAAACAGTG
GACTCTCTAAAAAATATCCTGACTTCTAATAACATTGATGTCAAGAAAATGACGGTCACA
GACCAGGTGAACTGCCCCAAGCTCTCGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:612
Chromosome Location3
LocusNot Available
References
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