NameArginase-1
Synonyms
  • 3.5.3.1
  • Liver-type arginase
  • Type I arginase
Gene NameARG1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000569|Arginase-1
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
Number of residues322
Molecular Weight34734.655
Theoretical pI7.25
GO Classification
Functions
  • arginase activity
  • manganese ion binding
Processes
  • response to methylmercury
  • aging
  • arginine catabolic process
  • cellular nitrogen compound metabolic process
  • response to selenium ion
  • arginine catabolic process to ornithine
  • small molecule metabolic process
  • response to vitamin A
  • cellular response to dexamethasone stimulus
  • response to vitamin E
  • cellular response to glucagon stimulus
  • urea cycle
  • cellular response to hydrogen peroxide
  • cellular response to transforming growth factor beta stimulus
  • cellular response to interleukin-4
  • collagen biosynthetic process
  • mammary gland involution
  • lung development
  • maternal process involved in female pregnancy
  • positive regulation of endothelial cell proliferation
  • polyamine metabolic process
  • protein homotrimerization
  • cellular response to lipopolysaccharide
  • regulation of L-arginine import
  • response to drug
  • response to amine
  • response to axon injury
  • response to cadmium ion
  • liver development
  • response to herbicide
  • response to amino acid
  • response to manganese ion
  • response to zinc ion
Components
  • mitochondrial outer membrane
  • cytosol
  • extracellular exosome
  • neuron projection
  • cytoplasm
  • nucleus
  • neuronal cell body
  • extracellular space
General FunctionManganese ion binding
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID178995
UniProtKB IDP05089
UniProtKB Entry NameARGI1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010062|Arginase-1 (ARG1)
ATGAGCGCCAAGTCCAGAACCATAGGGATTATTGGAGCTCCTTTCTCAAAGGGACAGCCA
CGAGGAGGGGTGGAAGAAGGCCCTACAGTATTGAGAAAGGCTGGTCTGCTTGAGAAACTT
AAAGAACAAGAGTGTGATGTGAAGGATTATGGGGACCTGCCCTTTGCTGACATCCCTAAT
GACAGTCCCTTTCAAATTGTGAAGAATCCAAGGTCTGTGGGAAAAGCAAGCGAGCAGCTG
GCTGGCAAGGTGGCAGAAGTCAAGAAGAACGGAAGAATCAGCCTGGTGCTGGGCGGAGAC
CACAGTTTGGCAATTGGAAGCATCTCTGGCCATGCCAGGGTCCACCCTGATCTTGGAGTC
ATCTGGGTGGATGCTCACACTGATATCAACACTCCACTGACAACCACAAGTGGAAACTTG
CATGGACAACCTGTATCTTTCCTCCTGAAGGAACTAAAAGGAAAGATTCCCGATGTGCCA
GGATTCTCCTGGGTGACTCCCTGTATATCTGCCAAGGATATTGTGTATATTGGCTTGAGA
GACGTGGACCCTGGGGAACACTACATTTTGAAAACTCTAGGCATTAAATACTTTTCAATG
ACTGAAGTGGACAGACTAGGAATTGGCAAGGTGATGGAAGAAACACTCAGCTATCTACTA
GGAAGAAAGAAAAGGCCAATTCATCTAAGTTTTGATGTTGACGGACTGGACCCATCTTTC
ACACCAGCTACTGGCACACCAGTCGTGGGAGGTCTGACATACAGAGAAGGTCTCTACATC
ACAGAAGAAATCTACAAAACAGGGCTACTCTCAGGATTAGATATAATGGAAGTGAACCCA
TCCCTGGGGAAGACACCAGAAGAAGTAACTCGAACAGTGAACACAGCAGTTGCAATAACC
TTGGCTTGTTTCGGACTTGCTCGGGAGGGTAATCACAAGCCTATTGACTACCTTAACCCA
CCTAAGTAA
GenBank Gene IDM14502
GeneCard IDNot Available
GenAtlas IDARG1
HGNC IDHGNC:663
Chromosome Location6
Locus6q23
References
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  2. Takiguchi M, Haraguchi Y, Mori M: Human liver-type arginase gene: structure of the gene and analysis of the promoter region. Nucleic Acids Res. 1988 Sep 26;16(18):8789-802. 3174433
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