Guanine nucleotide-binding protein G(i) subunit alpha-2

NameGuanine nucleotide-binding protein G(i) subunit alpha-2
Synonyms
  • Adenylate cyclase-inhibiting G alpha protein
  • GNAI2B
Gene NameGNAI2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009092|Guanine nucleotide-binding protein G(i) subunit alpha-2
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVL
PDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEA
ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Number of residues355
Molecular Weight40450.51
Theoretical pINot Available
GO Classification
Functions
  • metal ion binding
  • G-protein beta/gamma-subunit complex binding
  • signal transducer activity
  • G-protein coupled receptor binding
  • GTP binding
  • GTPase activity
Processes
  • regulation of calcium ion transport
  • cell division
  • negative regulation of adenylate cyclase activity
  • cell cycle
  • response to nutrient
  • platelet activation
  • cell proliferation
  • adenosine receptor signaling pathway
  • activation of MAPKK activity
  • signal transduction
  • negative regulation of synaptic transmission
  • G-protein coupled acetylcholine receptor signaling pathway
  • G-protein coupled receptor signaling pathway
  • blood coagulation
  • positive regulation of cell proliferation
  • gamma-aminobutyric acid signaling pathway
  • intracellular signal transduction
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • synaptic transmission
Components
  • centrosome
  • midbody
  • cytosol
  • cytoplasm
  • extracellular exosome
  • membrane
  • nucleoplasm
  • extracellular vesicle
  • plasma membrane
  • membrane raft
  • heterotrimeric G-protein complex
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP04899
UniProtKB Entry NameGNAI2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013607|Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)
ATGAGAGGTGCTGGGGAGTCAGGGAAGAGCACCATCGTCAAGCAGATGAAGATCATCCAC
GAGGATGGCTACTCCGAGGAGGAATGCCGGCAGTACCGGGCGGTTGTCTACAGCAACACC
ATCCAGTCCATCATGGCCATTGTCAAAGCCATGGGCAACCTGCAGATCGACTTTGCCGAC
CCCTCCAGAGCGGACGACGCCAGGCAGCTATTTGCACTGTCCTGCACCGCCGAGGAGCAA
GGCGTGCTCCCTGATGACCTGTCCGGCGTCATCCGGAGGCTCTGGGCTGACCATGGTGTG
CAGGCCTGCTTTGGCCGCTCAAGGGAATACCAGCTCAACGACTCAGCTGCCTACTACCTG
AACGACCTGGAGCGTATTGCACAGAGTGACTACATCCCCACACAGCAAGATGTGCTACGG
ACCCGCGTAAAGACCACGGGGATCGTGGAGACACACTTCACCTTCAAGGACCTACACTTC
AAGATGTTTGATGTGGGTGGTCAGCGGTCTGAGCGGAAGAAGTGGATCCACTGCTTTGAG
GGCGTCACAGCCATCATCTTCTGCGTAGCCTTGAGCGCCTATGACTTGGTGCTAGCTGAG
GACGAGGAGATGAACCGCATGCATGAGAGCATGAAGCTATTCGATAGCATCTGCAACAAC
AAGTGGTTCACAGACACGTCCATCATCCTCTTCCTCAACAAGAAGGACCTGTTTGAGGAG
AAGATCACACACAGTCCCCTGACCATCTGCTTCCCTGAGTACACAGGGGCCAACAAATAT
GATGAGGCAGCCAGCTACATCCAGAGTAAGTTTGAGGACCTGAATAAGCGCAAAGACACC
AAGGAGATCTACACGCACTTCACGTGCGCCACCGACACCAAGAACGTGCAGTTCGTGTTT
GACGCCGTCACCGATGTCATCATCAAGAACAACCTGAAGGACTGCGGCCTCTTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4385
Chromosome Location3
LocusNot Available
References
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