Cytochrome P450 1A1

NameCytochrome P450 1A1
Synonyms
  • 1.14.14.1
  • CYPIA1
  • Cytochrome P450 form 6
  • Cytochrome P450-C
  • Cytochrome P450-P1
Gene NameCYP1A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006827|Cytochrome P450 1A1
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Number of residues512
Molecular Weight58164.815
Theoretical pI8.47
GO Classification
Functions
  • monooxygenase activity
  • aromatase activity
  • oxygen binding
  • demethylase activity
  • steroid hydroxylase activity
  • flavonoid 3'-monooxygenase activity
  • oxidoreductase activity, acting on diphenols and related substances as donors
  • vitamin D 24-hydroxylase activity
  • oxidoreductase activity
  • iron ion binding
  • heme binding
Processes
  • epoxygenase P450 pathway
  • xenobiotic metabolic process
  • response to iron(III) ion
  • amine metabolic process
  • arachidonic acid metabolic process
  • response to nematode
  • response to drug
  • drug metabolic process
  • response to antibiotic
  • flavonoid metabolic process
  • aging
  • response to herbicide
  • hydrogen peroxide biosynthetic process
  • response to vitamin A
  • cell proliferation
  • omega-hydroxylase P450 pathway
  • response to virus
  • small molecule metabolic process
  • porphyrin-containing compound metabolic process
  • response to hyperoxia
  • response to arsenic-containing substance
  • oxidation-reduction process
  • camera-type eye development
  • response to hypoxia
  • hepatocyte differentiation
  • response to wounding
  • 9-cis-retinoic acid biosynthetic process
  • positive regulation of G1/S transition of mitotic cell cycle
  • vitamin D metabolic process
  • response to lipopolysaccharide
  • coumarin metabolic process
  • cellular response to organic cyclic compound
  • cellular lipid metabolic process
  • dibenzo-p-dioxin catabolic process
  • digestive tract development
  • response to immobilization stress
  • embryo development ending in birth or egg hatching
  • maternal process involved in parturition
  • response to food
  • insecticide metabolic process
Components
  • mitochondrion
  • endoplasmic reticulum membrane
General FunctionVitamin d 24-hydroxylase activity
Specific FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181276
UniProtKB IDP04798
UniProtKB Entry NameCP1A1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0012466|Cytochrome P450 1A1 (CYP1A1)
ATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTTCTGGCCTCTGTCATCTTCTGT
CTGGTATTCTGGGTAATCAGGGCCTCAAGACCTCAGGTCCCCAAAGGCCTGAAGAATCCA
CCAGGGCCATGGGGCTGGCCTCTGATTGGGCACATGCTGACCCTGGGAAAGAACCCGCAC
CTGGCACTGTCAAGGATGAGCCAGCAGTATGGGGACGTGCTGCAGATCCGAATTGGCTCC
ACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGGCAGGCCCTGGTGCGGCAGGGC
GATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACCCTCATCAGTAATGGTCAGAGC
ATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCCCGCCGGCGCCTGGCCCAGAAT
GGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCCTCAACCTCCTGCTACCTGGAA
GAGCATGTGAGCAAGGAGGCTGAGGTCCTGATAAGCACGTTGCAGGAGCTGATGGCAGGG
CCTGGGCACTTTAACCCCTACAGGTATGTGGTGGTATCAGTGACCAATGTCATCTGTGCC
ATTTGCTTTGGCCGGCGCTATGACCACAACCACCAAGAACTGCTTAGCCTAGTCAACCTG
AATAATAATTTCGGGGAGGTGGTTGGCTCTGGAAACCCAGCTGACTTCATCCCTATTCTT
CGCTACCTACCCAACCCTTCCCTGAATGCCTTCAAGGACCTGAATGAGAAGTTCTACAGC
TTCATGCAGAAGATGGTCAAGGAGCACTACAAAACCTTTGAGAAGGGCCACATCCGGGAC
ATCACAGACAGCCTGATTGAGCACTGTCAGGAGAAGCAGCTGGATGAGAACGCCAATGTC
CAGCTGTCAGATGAGAAGATCATTAACATCGTCTTGGACCTCTTTGGAGCTGGGTTTGAC
ACAGTCACAACTGCTATCTCCTGGAGCCTCATGTATTTGGTGATGAACCCCAGGGTACAG
AGAAAGATCCAAGAGGAGCTAGACACAGTGATTGGCAGGTCACGGCGGCCCCGGCTCTCT
GACAGATCCCATCTGCCCTATATGGAGGCCTTCATCCTGGAGACCTTCCGACACTCTTCC
TTCGTCCCCTTCACCATCCCCCACAGCACAACAAGAGACACAAGTTTGAAAGGCTTTTAC
ATCCCCAAGGGGCGTTGTGTCTTTGTAAACCAGTGGCAGATCAACCATGACCAGAAGCTA
TGGGTCAACCCATCTGAGTTCCTACCTGAACGGTTTCTCACCCCTGATGGTGCTATCGAC
AAGGTGTTAAGTGAGAAGGTGATTATCTTTGGCATGGGCAAGCGGAAGTGTATCGGTGAG
ACCATTGCCCGCTGGGAGGTCTTTCTCTTCCTGGCTATCCTGCTGCAACGGGTGGAATTC
AGCGTGCCACTGGGCGTGAAGGTGGACATGACCCCCATCTATGGGCTAACCATGAAGCAT
GCCTGCTGTGAGCACTTCCAAATGCAGCTGCGCTCTTAG
GenBank Gene IDK03191
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2595
Chromosome Location15
Locus15q24.1
References
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