NameThymidine kinase, cytosolic
Synonyms
  • 2.7.1.21
Gene NameTK1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020515|Thymidine kinase, cytosolic
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
Number of residues234
Molecular Weight25468.455
Theoretical pI8.61
GO Classification
Functions
  • zinc ion binding
  • ATP binding
  • nucleoside kinase activity
  • thymidine kinase activity
  • identical protein binding
Processes
  • pyrimidine nucleobase metabolic process
  • deoxyribonucleoside monophosphate biosynthetic process
  • digestive tract development
  • nucleotide biosynthetic process
  • pyrimidine nucleoside salvage
  • small molecule metabolic process
  • response to cortisol
  • thymidine metabolic process
  • fetal process involved in parturition
  • nucleobase-containing small molecule metabolic process
  • skeletal muscle cell proliferation
  • protein homotetramerization
  • response to nutrient levels
  • response to toxic substance
  • DNA biosynthetic process
  • nucleobase-containing compound metabolic process
  • liver development
  • response to copper ion
Components
  • cytosol
General FunctionZinc ion binding
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID339709
UniProtKB IDP04183
UniProtKB Entry NameKITH_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020516|Thymidine kinase, cytosolic (TK1)
ATGAGCTGCATTAACCTGCCCACTGTGCTGCCTGGCTCCCCCAGCAAGACCCGGGGGCAG
ATCCAGGTGATTCTCGGGCCGATGTTCTCAGGAAAAAGCACAGAGTTGATGAGACGCGTC
CGTCGCTTCCAGATTGCTCAGTACAAGTGCCTGGTGATCAAGTATGCCAAAGACACTCGC
TACAGCAGCAGCTTCTGCACACATGACCGGAACACCATGGAGGCACTGCCCGCCTGCCTG
CTCCGAGACGTGGCCCAGGAGGCCCTGGGCGTGGCTGTCATAGGCATCGACGAGGGGCAG
TTTTTCCCTGACATCGTGGAGTTCTGCGAGGCCATGGCCAACGCCGGGAAGACCGTAATT
GTGGCTGCACTGGATGGGACCTTCCAGAGGAAGCCATTTGGGGCCATCCTGAACCTGGTG
CCGCTGGCCGAGAGCGTGGTGAAGCTGACGGCGGTGTGCATGGAGTGCTTCCGGGAAGCC
GCCTATACCAAGAGGCTCGGCACAGAGAAGGAGGTCGAGGTGATTGGGGGAGCAGACAAG
TACCACTCCGTGTGTCGGCTCTGCTACTTCAAGAAGGCCTCAGGCCAGCCTGCCGGGCCG
GACAACAAAGAGAACTGCCCAGTGCCAGGAAAGCCAGGGGAAGCCGTGGCTGCCAGGAAG
CTCTTTGCCCCACAGCAGATTCTGCAATGCAGCCCTGCCAACTGA
GenBank Gene IDK02581
GeneCard IDNot Available
GenAtlas IDTK1
HGNC IDHGNC:11830
Chromosome Location17
Locus17q23.2-q25.3
References
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