Angiogenin

NameAngiogenin
Synonyms
  • 3.1.27.-
  • Ribonuclease 5
  • RNase 5
  • RNASE5
Gene NameANG
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002349|Angiogenin
MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLT
SPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRA
TAGFRNVVVACENGLPVHLDQSIFRRP
Number of residues147
Molecular Weight16549.95
Theoretical pI10.09
GO Classification
Functions
  • rRNA binding
  • copper ion binding
  • peptide binding
  • DNA binding
  • receptor binding
  • endonuclease activity
  • ribonuclease activity
  • actin binding
  • heparin binding
  • protein homodimerization activity
Processes
  • innate immune response
  • rRNA transcription
  • cell communication
  • ovarian follicle development
  • nucleic acid phosphodiester bond hydrolysis
  • response to hypoxia
  • oocyte maturation
  • antibacterial humoral response
  • angiogenesis
  • defense response to Gram-positive bacterium
  • RNA phosphodiester bond hydrolysis
  • activation of phospholipase C activity
  • negative regulation of translation
  • antifungal humoral response
  • positive regulation of endothelial cell proliferation
  • response to hormone
  • activation of phospholipase A2 activity
  • actin filament polymerization
  • adherens junction organization
  • cell junction assembly
  • activation of protein kinase B activity
  • placenta development
  • cell-cell junction organization
  • response to yeast
  • diacylglycerol biosynthetic process
  • homeostatic process
  • positive regulation of protein secretion
  • cell migration
  • positive regulation of phosphorylation
  • negative regulation of smooth muscle cell proliferation
Components
  • extracellular region
  • nucleus
  • growth cone
  • neuronal cell body
  • extracellular space
  • angiogenin-PRI complex
  • extracellular exosome
  • basal lamina
  • nucleolus
General FunctionRrna binding
Specific FunctionBinds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID178250
UniProtKB IDP03950
UniProtKB Entry NameANGI_HUMAN
Cellular LocationCytoplasmic vesicle
Gene sequence
>lcl|BSEQ0010823|Angiogenin (ANG)
ATGGTGATGGGCCTGGGCGTTTTGTTGTTGGTCTTCGTGCTGGGTCTGGGTCTGACCCCA
CCGACCCTGGCTCAGGATAACTCCAGGTACACACACTTCCTGACCCAGCACTATGATGCC
AAACCACAGGGCCGGGATGACAGATACTGTGAAAGCATCATGAGGAGACGGGGCCTGACC
TCACCCTGCAAAGACATCAACACATTTATTCATGGCAACAAGCGCAGCATCAAGGCCATC
TGTGAAAACAAGAATGGAAACCCTCACAGAGAAAACCTAAGAATAAGCAAGTCTTCTTTC
CAGGTCACCACTTGCAAGCTACATGGAGGTTCCCCCTGGCCTCCATGCCAGTACCGAGCC
ACAGCGGGGTTCAGAAACGTTGTTGTTGCTTGTGAAAATGGCTTACCTGTCCACTTGGAT
CAGTCAATTTTCCGTCGTCCGTAA
GenBank Gene IDM11567
GeneCard IDNot Available
GenAtlas IDANG
HGNC IDHGNC:483
Chromosome Location14
Locus14q11.1-q11.2
References
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