Platelet factor 4

NamePlatelet factor 4
Synonyms
  • C-X-C motif chemokine 4
  • CXCL4
  • Iroplact
  • Oncostatin-A
  • PF-4
  • SCYB4
Gene NamePF4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010788|Platelet factor 4
MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEV
IKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES
Number of residues101
Molecular Weight10844.78
Theoretical pI8.78
GO Classification
Functions
  • heparin binding
  • chemokine activity
  • CXCR3 chemokine receptor binding
Processes
  • cytokine-mediated signaling pathway
  • positive regulation of gene expression
  • blood coagulation
  • positive regulation of cAMP-mediated signaling
  • immune response
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • chemokine-mediated signaling pathway
  • inflammatory response
  • negative regulation of angiogenesis
  • platelet activation
  • positive regulation of macrophage differentiation
  • regulation of cell proliferation
  • positive regulation of transcription from RNA polymerase II promoter
  • leukocyte chemotaxis
  • negative regulation of cytolysis
  • platelet degranulation
  • negative regulation of megakaryocyte differentiation
  • G-protein coupled receptor signaling pathway
  • negative regulation of MHC class II biosynthetic process
  • positive regulation of tumor necrosis factor production
  • positive regulation of cAMP metabolic process
  • positive regulation of macrophage derived foam cell differentiation
  • positive regulation of leukocyte chemotaxis
  • response to lipopolysaccharide
Components
  • extracellular region
  • extracellular space
  • platelet alpha granule lumen
General FunctionHeparin binding
Specific FunctionReleased during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID189851
UniProtKB IDP02776
UniProtKB Entry NamePLF4_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010789|Platelet factor 4 (PF4)
ATGAGCTCCGCAGCCGGGTTCTGCGCCTCACGCCCCGGGCTGCTGTTCCTGGGGTTGCTG
CTCCTGCCACTTGTGGTCGCCTTCGCCAGCGCTGAAGCTGAAGAAGATGGGGACCTGCAG
TGCCTGTGTGTGAAGACCACCTCCCAGGTCCGTCCCAGGCACATCACCAGCCTGGAGGTG
ATCAAGGCCGGACCCCACTGCCCCACTGCCCAACTGATAGCCACGCTGAAGAATGGAAGG
AAAATTTGCTTGGACCTGCAAGCCCCGCTGTACAAGAAAATAATTAAGAAACTTTTGGAG
AGTTAG
GenBank Gene IDM25897
GeneCard IDNot Available
GenAtlas IDPF4
HGNC IDHGNC:8861
Chromosome Location4
Locus4q12-q21
References
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  2. Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M: Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood. 1990 Jul 15;76(2):336-44. 1695112
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