Vitamin D-binding protein

NameVitamin D-binding protein
Synonyms
  • DBP
  • DBP-maf
  • Gc
  • Gc protein-derived macrophage activating factor
  • Gc-globulin
  • Gc-MAF
  • GcMAF
  • Group-specific component
  • Vitamin D-binding protein-macrophage activating factor
Gene NameGC
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002269|Vitamin D-binding protein
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
KLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
Number of residues474
Molecular Weight52963.025
Theoretical pI5.21
GO Classification
Functions
  • calcidiol binding
  • vitamin D binding
  • vitamin transporter activity
  • actin binding
Processes
  • response to estradiol
  • steroid metabolic process
  • response to nutrient levels
  • female pregnancy
  • vitamin D metabolic process
  • vitamin transport
  • lactation
  • small molecule metabolic process
Components
  • perinuclear region of cytoplasm
  • blood microparticle
  • lysosomal lumen
  • axon
  • extracellular region
  • extracellular space
  • cytosol
  • extracellular exosome
General FunctionVitamin transporter activity
Specific FunctionInvolved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID639896
UniProtKB IDP02774
UniProtKB Entry NameVTDB_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010798|Vitamin D-binding protein (GC)
ATGAAGAGGGTCCTGGTACTACTGCTTGCTGTGGCATTTGGACATGCTTTAGAGAGAGGC
CGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGGGAAAGGAGGACTTC
ACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTC
AGCCAACTTGTGAAGGAAGTTGTCTCCTTGACCGAAGCCTGCTGTGCGGAAGGGGCTGAC
CCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCTGTGAAAGTAATTCT
CCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAG
CTCTGCATGGCTGCTCTGAAACACCAGCCACAGGAATTCCCTACCTACGTGGAACCCACA
AATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATGCTAATCAATTTATG
TGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAG
AGTTATCTTTCTATGGTAGGGTCCTGCTGTACCTCTGCAAGCCCAACTGTATGCTTTTTG
AAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGTCAAATAGAGTCTGC
TCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCAATCTCATAAAGTTAGCC
CAAAAAGTGCCTACTGCTGATCTGGAGGATGTTTTGCCACTAGCTGAAGATATTACTAAC
ATCCTCTCCAAATGCTGTGAGTCTGCCTCTGAAGATTGCATGGCCAAAGAGCTGCCTGAA
CACACAGTAAAACTCTGTGACAATTTATCCACAAAGAATTCTAAGTTTGAAGACTGTTGT
CAAGAAAAAACAGCCATGGACGTTTTTGTGTGCACTTACTTCATGCCAGCTGCCCAACTC
CCCGAGCTTCCAGATGTAGAGTTGCCCACAAACAAAGATGTGTGTGATCCAGGAAACACC
AAAGTCATGGATAAGTATACATTTGAACTAAGCAGAAGGACTCATCTTCCGGAAGTATTC
CTCAGTAAGGTACTTGAGCCAACCCTAAAAAGCCTTGGTGAATGCTGTGATGTTGAAGAC
TCAACTACCTGTTTTAATGCTAAGGGCCCTCTACTAAAGAAGGAACTATCTTCTTTCATT
GACAAGGGACAAGAACTATGTGCAGATTATTCAGAAAATACATTTACTGAGTACAAGAAA
AAACTGGCAGAGCGACTAAAAGCAAAATTGCCTGATGCCACACCCACGGAACTGGCAAAG
CTGGTTAACAAGCACTCAGACTTTGCCTCCAACTGCTGTTCCATAAACTCACCTCCTCTT
TACTGTGATTCAGAGATTGATGCTGAATTGAAGAATATCCTGTAG
GenBank Gene IDL10641
GeneCard IDNot Available
GenAtlas IDGC
HGNC IDHGNC:4187
Chromosome Location4
Locus4q12-q13
References
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