Retinol-binding protein 4

NameRetinol-binding protein 4
Synonyms
  • Plasma retinol-binding protein
  • PRBP
  • RBP
Gene NameRBP4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000625|Retinol-binding protein 4
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIV
AEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGND
DHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLA
RQYRLIVHNGYCDGRSERNLL
Number of residues201
Molecular Weight23009.8
Theoretical pI5.85
GO Classification
Functions
  • retinal binding
  • retinol binding
  • retinol transporter activity
Processes
  • glucose homeostasis
  • embryonic retina morphogenesis in camera-type eye
  • embryonic skeletal system development
  • eye development
  • lung development
  • female genitalia morphogenesis
  • heart development
  • heart trabecula formation
  • phototransduction, visible light
  • maintenance of gastrointestinal epithelium
  • negative regulation of cardiac muscle cell proliferation
  • positive regulation of immunoglobulin secretion
  • retinol transport
  • urinary bladder development
  • retinoid metabolic process
  • vagina development
  • response to ethanol
  • retinol metabolic process
  • uterus development
  • gluconeogenesis
  • cardiac muscle tissue development
  • visual perception
  • response to retinoic acid
  • positive regulation of insulin secretion
  • embryonic organ morphogenesis
Components
  • protein complex
  • extracellular region
  • extracellular space
  • cytosol
  • extracellular exosome
General FunctionRetinol transporter activity
Specific FunctionDelivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID35897
UniProtKB IDP02753
UniProtKB Entry NameRET4_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010244|Retinol-binding protein 4 (RBP4)
ATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGGGCAGCGGCCGCGCGGAGCGC
GACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGGCTCGCTTCTCTGGG
ACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTC
GCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGT
CTTTTGAATAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCACAGACACCGAGGAC
CCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAATGAT
GACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTACTCCTGCCGCCTC
CTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAAC
GGCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCC
AGGCAGTACAGGCTGATCGTCCACAACGGTTACTGCGATGGCAGATCAGAAAGAAACCTT
TTGTAG
GenBank Gene IDX00129
GeneCard IDNot Available
GenAtlas IDRBP4
HGNC IDHGNC:9922
Chromosome Location10
Locus10q23-q24
References
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