Apolipoprotein E

NameApolipoprotein E
Synonyms
  • Apo-E
Gene NameAPOE
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021928|Apolipoprotein E
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT
LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA
RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY
QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG
SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
VQAAVGTSAAPVPSDNH
Number of residues317
Molecular Weight36153.83
Theoretical pI5.42
GO Classification
Functions
  • antioxidant activity
  • cholesterol transporter activity
  • identical protein binding
  • heparin binding
  • phosphatidylcholine-sterol O-acyltransferase activator activity
  • lipoprotein particle binding
  • lipid transporter activity
  • lipid binding
  • very-low-density lipoprotein particle receptor binding
  • phospholipid binding
  • metal chelating activity
  • low-density lipoprotein particle receptor binding
  • beta-amyloid binding
  • tau protein binding
  • cholesterol binding
  • protein homodimerization activity
Processes
  • very-low-density lipoprotein particle remodeling
  • retinoid metabolic process
  • triglyceride catabolic process
  • negative regulation of lipid transport across blood brain barrier
  • positive regulation of cGMP biosynthetic process
  • regulation of axon extension
  • fatty acid homeostasis
  • cGMP-mediated signaling
  • negative regulation of neuron apoptotic process
  • long-chain fatty acid transport
  • cholesterol efflux
  • negative regulation of phospholipid efflux
  • negative regulation of MAP kinase activity
  • receptor-mediated endocytosis
  • negative regulation of cholesterol biosynthetic process
  • positive regulation by host of viral process
  • cholesterol homeostasis
  • triglyceride metabolic process
  • cholesterol biosynthetic process
  • negative regulation of dendritic spine development
  • negative regulation of cholesterol efflux
  • cholesterol metabolic process
  • negative regulation of postsynaptic membrane organization
  • response to reactive oxygen species
  • high-density lipoprotein particle assembly
  • negative regulation of presynaptic membrane organization
  • cytoskeleton organization
  • lipoprotein biosynthetic process
  • cholesterol catabolic process
  • lipoprotein metabolic process
  • positive regulation of beta-amyloid formation
  • positive regulation of membrane protein ectodomain proteolysis
  • G-protein coupled receptor signaling pathway
  • artery morphogenesis
  • phospholipid efflux
  • positive regulation of dendritic spine maintenance
  • negative regulation of neuron death
  • synaptic transmission, cholinergic
  • NMDA glutamate receptor clustering
  • positive regulation of cholesterol efflux
  • positive regulation of lipid transport across blood brain barrier
  • virion assembly
  • AMPA glutamate receptor clustering
  • regulation of Cdc42 protein signal transduction
  • positive regulation of neurofibrillary tangle assembly
  • vasodilation
  • negative regulation of platelet activation
  • positive regulation of low-density lipoprotein particle receptor catabolic process
  • lipoprotein catabolic process
  • reverse cholesterol transport
  • positive regulation of phospholipid efflux
  • positive regulation of postsynaptic membrane organization
  • positive regulation of lipid biosynthetic process
  • regulation of gene expression
  • negative regulation of lipid biosynthetic process
  • intracellular transport
  • neuron projection regeneration
  • cellular calcium ion homeostasis
  • positive regulation of presynaptic membrane organization
  • response to dietary excess
  • low-density lipoprotein particle remodeling
  • very-low-density lipoprotein particle clearance
  • protein import
  • positive regulation of dendritic spine development
  • high-density lipoprotein particle clearance
  • regulation of beta-amyloid clearance
  • positive regulation of neuron death
  • positive regulation of cholesterol esterification
  • nitric oxide mediated signal transduction
  • regulation of neuron death
  • high-density lipoprotein particle remodeling
  • positive regulation of nitric-oxide synthase activity
  • regulation of tau-protein kinase activity
  • phototransduction, visible light
  • maintenance of location in cell
  • small molecule metabolic process
  • negative regulation of inflammatory response
  • negative regulation of beta-amyloid formation
  • negative regulation of blood vessel endothelial cell migration
  • chylomicron remnant clearance
  • negative regulation of blood coagulation
  • regulation of neuronal synaptic plasticity
  • negative regulation of dendritic spine maintenance
  • negative regulation of endothelial cell proliferation
Components
  • extracellular matrix
  • extracellular region
  • nucleus
  • low-density lipoprotein particle
  • extracellular vesicle
  • endocytic vesicle lumen
  • endoplasmic reticulum
  • dendrite
  • high-density lipoprotein particle
  • plasma membrane
  • very-low-density lipoprotein particle
  • blood microparticle
  • extracellular space
  • early endosome
  • Golgi apparatus
  • chylomicron
  • intermediate-density lipoprotein particle
  • neuronal cell body
  • cytoplasm
  • extracellular exosome
  • membrane
General FunctionVery-low-density lipoprotein particle receptor binding
Specific FunctionMediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID178849
UniProtKB IDP02649
UniProtKB Entry NameAPOE_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021929|Apolipoprotein E (APOE)
ATGAAGGTTCTGTGGGCTGCGTTGCTGGTCACATTCCTGGCAGGATGCCAGGCCAAGGTG
GAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCAGACCGAGTGGCAGAGC
GGCCAGCGCTGGGAACTGGCACTGGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACA
CTGTCTGAGCAGGTGCAGGAGGAGCTGCTCAGCTCCCAGGTCACCCAGGAACTGAGGGCG
CTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGAACTGGAGGAACAACTG
ACCCCGGTGGCGGAGGAGACGCGGGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCC
CGGCTGGGCGCGGACATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGGCGAGGTG
CAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCTCGCCTCCCACCTGCGC
AAGCTGCGTAAGCGGCTCCTCCGCGATGCCGATGACCTGCAGAAGCGCCTGGCAGTGTAC
CAGGCCGGGGCCCGCGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCGCCTGGGG
CCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTCCCTGGCCGGCCAGCCG
CTACAGGAGCGGGCCCAGGCCTGGGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGC
AGCCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCGCGCCAAG
CTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTTCCAGGCCCGCCTCAAG
AGCTGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAG
GTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTGA
GenBank Gene IDM12529
GeneCard IDNot Available
GenAtlas IDAPOE
HGNC IDHGNC:613
Chromosome Location19
Locus19q13.2
References
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