Apolipoprotein A-I

NameApolipoprotein A-I
Synonyms
  • Apo-AI
  • Apolipoprotein A1
Gene NameAPOA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017103|Apolipoprotein A-I
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ
Number of residues267
Molecular Weight30777.58
Theoretical pI5.5
GO Classification
Functions
  • cholesterol binding
  • phosphatidylcholine-sterol O-acyltransferase activator activity
  • cholesterol transporter activity
  • phospholipid transporter activity
  • identical protein binding
  • phospholipid binding
  • lipase inhibitor activity
  • beta-amyloid binding
  • high-density lipoprotein particle binding
  • apolipoprotein A-I receptor binding
  • enzyme binding
  • apolipoprotein receptor binding
  • phosphatidylcholine binding
  • chemorepellent activity
  • high-density lipoprotein particle receptor binding
Processes
  • peripheral nervous system axon regeneration
  • blood coagulation
  • endothelial cell proliferation
  • transmembrane transport
  • triglyceride homeostasis
  • adrenal gland development
  • negative regulation of interleukin-1 beta secretion
  • regulation of intestinal cholesterol absorption
  • lipoprotein biosynthetic process
  • glucocorticoid metabolic process
  • neuron projection regeneration
  • positive regulation of stress fiber assembly
  • negative regulation of cell adhesion molecule production
  • response to nutrient
  • negative regulation of response to cytokine stimulus
  • response to drug
  • cellular lipid metabolic process
  • triglyceride catabolic process
  • negative regulation of cytokine secretion involved in immune response
  • receptor-mediated endocytosis
  • retinoid metabolic process
  • lipid storage
  • cholesterol efflux
  • positive regulation of substrate adhesion-dependent cell spreading
  • negative regulation of very-low-density lipoprotein particle remodeling
  • cellular protein metabolic process
  • cholesterol biosynthetic process
  • regulation of protein phosphorylation
  • cholesterol homeostasis
  • protein oxidation
  • cholesterol metabolic process
  • peptidyl-methionine modification
  • platelet degranulation
  • cholesterol transport
  • high-density lipoprotein particle assembly
  • negative regulation of lipase activity
  • G-protein coupled receptor signaling pathway
  • organ regeneration
  • positive regulation of lipoprotein lipase activity
  • lipoprotein metabolic process
  • negative chemotaxis
  • positive regulation of triglyceride catabolic process
  • vitamin transport
  • phospholipid efflux
  • positive regulation of hydrolase activity
  • integrin-mediated signaling pathway
  • phosphatidylcholine biosynthetic process
  • very-low-density lipoprotein particle remodeling
  • platelet activation
  • phospholipid homeostasis
  • positive regulation of fatty acid biosynthetic process
  • positive regulation of cholesterol esterification
  • negative regulation of tumor necrosis factor-mediated signaling pathway
  • regulation of Cdc42 protein signal transduction
  • response to estrogen
  • blood vessel endothelial cell migration
  • reverse cholesterol transport
  • phototransduction, visible light
  • positive regulation of Rho protein signal transduction
  • small molecule metabolic process
  • cholesterol import
  • negative regulation of inflammatory response
  • high-density lipoprotein particle clearance
  • negative regulation of heterotypic cell-cell adhesion
  • protein stabilization
  • high-density lipoprotein particle remodeling
Components
  • extracellular region
  • endoplasmic reticulum lumen
  • nucleus
  • plasma membrane
  • endocytic vesicle lumen
  • secretory granule lumen
  • extracellular vesicle
  • early endosome
  • chylomicron
  • extracellular space
  • cell surface
  • blood microparticle
  • cytoplasmic vesicle
  • discoidal high-density lipoprotein particle
  • high-density lipoprotein particle
  • spherical high-density lipoprotein particle
  • very-low-density lipoprotein particle
  • cytosol
  • endocytic vesicle
  • extracellular exosome
General FunctionPhospholipid transporter activity
Specific FunctionParticipates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP02647
UniProtKB Entry NameAPOA1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0017104|Apolipoprotein A-I (APOA1)
ATGAAAGCTGCGGTGCTGACCTTGGCCGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCAT
TTCTGGCAGCAAGATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACT
GTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGTCCCAGTTTGAAGGCTCC
GCCTTGGGAAAACAGCTAAACCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACC
TTCAGCAAGCTGCGCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAA
AAGGAGACAGAGGGCCTGAGGCAGGAGATGAGCAAGGATCTGGAGGAGGTGAAGGCCAAG
GTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGC
CAGAAGGTGGAGCCGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAG
CTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACCGCGCGCGCGCCCATGTG
GACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCG
CGCCTTGAGGCTCTCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCC
ACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGCTCGAGGACCTCCGCCAA
GGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTAC
ACTAAGAAGCTCAACACCCAGTGA
GenBank Gene IDBC110286
GeneCard IDNot Available
GenAtlas IDAPOA1
HGNC IDHGNC:600
Chromosome Location11
LocusNot Available
References
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