Apolipoprotein A-I

NameApolipoprotein A-I
Synonyms
  • Apo-AI
  • Apolipoprotein A1
Gene NameAPOA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017103|Apolipoprotein A-I
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ
Number of residues267
Molecular Weight30777.58
Theoretical pI5.5
GO Classification
Functions
  • enzyme binding
  • lipase inhibitor activity
  • beta-amyloid binding
  • cholesterol binding
  • cholesterol transporter activity
  • identical protein binding
  • high-density lipoprotein particle binding
  • phospholipid transporter activity
  • apolipoprotein A-I receptor binding
  • apolipoprotein receptor binding
  • phosphatidylcholine binding
  • phospholipid binding
  • chemorepellent activity
  • high-density lipoprotein particle receptor binding
  • phosphatidylcholine-sterol O-acyltransferase activator activity
Processes
  • phospholipid homeostasis
  • negative regulation of response to cytokine stimulus
  • integrin-mediated signaling pathway
  • triglyceride catabolic process
  • platelet activation
  • negative regulation of cytokine secretion involved in immune response
  • regulation of Cdc42 protein signal transduction
  • lipid storage
  • positive regulation of cholesterol esterification
  • positive regulation of substrate adhesion-dependent cell spreading
  • negative regulation of very-low-density lipoprotein particle remodeling
  • reverse cholesterol transport
  • regulation of protein phosphorylation
  • response to estrogen
  • protein oxidation
  • cholesterol import
  • phototransduction, visible light
  • peptidyl-methionine modification
  • small molecule metabolic process
  • high-density lipoprotein particle clearance
  • negative regulation of inflammatory response
  • negative regulation of lipase activity
  • high-density lipoprotein particle remodeling
  • organ regeneration
  • positive regulation of lipoprotein lipase activity
  • negative chemotaxis
  • transmembrane transport
  • triglyceride homeostasis
  • blood coagulation
  • positive regulation of triglyceride catabolic process
  • positive regulation of hydrolase activity
  • positive regulation of fatty acid biosynthetic process
  • adrenal gland development
  • phosphatidylcholine biosynthetic process
  • very-low-density lipoprotein particle remodeling
  • glucocorticoid metabolic process
  • negative regulation of tumor necrosis factor-mediated signaling pathway
  • receptor-mediated endocytosis
  • response to nutrient
  • blood vessel endothelial cell migration
  • response to drug
  • cellular lipid metabolic process
  • cellular protein metabolic process
  • retinoid metabolic process
  • positive regulation of Rho protein signal transduction
  • cholesterol efflux
  • cholesterol biosynthetic process
  • cholesterol homeostasis
  • negative regulation of heterotypic cell-cell adhesion
  • protein stabilization
  • cholesterol metabolic process
  • peripheral nervous system axon regeneration
  • platelet degranulation
  • endothelial cell proliferation
  • cholesterol transport
  • high-density lipoprotein particle assembly
  • negative regulation of interleukin-1 beta secretion
  • G-protein coupled receptor signaling pathway
  • regulation of intestinal cholesterol absorption
  • lipoprotein biosynthetic process
  • lipoprotein metabolic process
  • neuron projection regeneration
  • positive regulation of stress fiber assembly
  • vitamin transport
  • negative regulation of cell adhesion molecule production
  • phospholipid efflux
Components
  • cytoplasmic vesicle
  • secretory granule lumen
  • chylomicron
  • cytosol
  • extracellular exosome
  • endocytic vesicle
  • endoplasmic reticulum lumen
  • extracellular region
  • discoidal high-density lipoprotein particle
  • nucleus
  • high-density lipoprotein particle
  • spherical high-density lipoprotein particle
  • plasma membrane
  • very-low-density lipoprotein particle
  • endocytic vesicle lumen
  • extracellular vesicle
  • early endosome
  • extracellular space
  • cell surface
  • blood microparticle
General FunctionPhospholipid transporter activity
Specific FunctionParticipates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP02647
UniProtKB Entry NameAPOA1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0017104|Apolipoprotein A-I (APOA1)
ATGAAAGCTGCGGTGCTGACCTTGGCCGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCAT
TTCTGGCAGCAAGATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACT
GTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGTCCCAGTTTGAAGGCTCC
GCCTTGGGAAAACAGCTAAACCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACC
TTCAGCAAGCTGCGCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAA
AAGGAGACAGAGGGCCTGAGGCAGGAGATGAGCAAGGATCTGGAGGAGGTGAAGGCCAAG
GTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGC
CAGAAGGTGGAGCCGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAG
CTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACCGCGCGCGCGCCCATGTG
GACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCG
CGCCTTGAGGCTCTCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCC
ACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGCTCGAGGACCTCCGCCAA
GGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTAC
ACTAAGAAGCTCAACACCCAGTGA
GenBank Gene IDBC110286
GeneCard IDNot Available
GenAtlas IDAPOA1
HGNC IDHGNC:600
Chromosome Location11
LocusNot Available
References
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