NameTroponin C, skeletal muscle
SynonymsNot Available
Gene NameTNNC2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012479|Troponin C, skeletal muscle
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAII
EEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIF
RASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
Number of residues160
Molecular Weight18121.895
Theoretical pI3.81
GO Classification
Functions
  • calcium ion binding
Processes
  • muscle filament sliding
  • regulation of muscle contraction
  • skeletal muscle contraction
Components
  • cytosol
  • troponin complex
General FunctionCalcium ion binding
Specific FunctionTroponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36729
UniProtKB IDP02585
UniProtKB Entry NameTNNC2_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0012480|Troponin C, skeletal muscle (TNNC2)
ATGACGGACCAGCAGGCTGAGGCCAGGTCCTACCTCAGCGAAGAGATGATCGCTGAGTTC
AAGGCTGCCTTTGACATGTTTGATGCTGATGGTGGTGGGGACATCAGCGTCAAGGAGTTG
GGCACGGTGATGAGGATGCTGGGCCAGACACCCACCAAGGAGGAGCTGGACGCCATCATC
GAGGAGGTGGATGAGGACGGCAGCGGCACCATCGACTTCGAGGAGTTCTTGGTCATGATG
GTGCGCCAGATGAAAGAGGACGCGAAAGGGAAGAGCGAGGAGGAGCTGGCCGAGTGCTTC
CGCATCTTCGACAGGAATGCAGACGGCTACATCGACCCGGAGGAGCTGGCTGAGATTTTC
AGGGCCTCCGGGGAGCACGTGACGGACGAGGAGATCGAATCTCTGATGAAAGACGGCGAC
AAGAACAACGACGGCCGCATTGACTTCGACGAGTTCCTGAAGATGATGGAGGGCGTGCAG
TAA
GenBank Gene IDX07898
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11944
Chromosome Location20
Locus20q12-q13.11
References
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  2. Gahlmann R, Kedes L: Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. J Biol Chem. 1990 Jul 25;265(21):12520-8. 2373703
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