Interleukin-1 beta

NameInterleukin-1 beta
Synonyms
  • Catabolin
  • IL-1 beta
  • IL1F2
Gene NameIL1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010736|Interleukin-1 beta
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
Number of residues269
Molecular Weight30747.7
Theoretical pI4.45
GO Classification
Functions
  • interleukin-1 receptor binding
  • protein domain specific binding
  • cytokine activity
Processes
  • cellular response to organic substance
  • monocyte aggregation
  • apoptotic process
  • positive regulation of heterotypic cell-cell adhesion
  • positive regulation of chemokine biosynthetic process
  • inflammatory response
  • positive regulation of myosin light chain kinase activity
  • lipopolysaccharide-mediated signaling pathway
  • response to vitamin D
  • negative regulation of adiponectin secretion
  • MAPK cascade
  • embryo implantation
  • positive regulation of interleukin-6 biosynthetic process
  • positive regulation of NF-kappaB import into nucleus
  • estrogen metabolic process
  • ovulation
  • negative regulation of branching morphogenesis of a nerve
  • negative regulation of cell proliferation
  • negative regulation of glutamate secretion
  • positive regulation of membrane protein ectodomain proteolysis
  • positive regulation of protein export from nucleus
  • positive regulation of ERK1 and ERK2 cascade
  • negative regulation of MAP kinase activity
  • negative regulation of lipid metabolic process
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of neuron differentiation
  • cell-cell signaling
  • positive regulation of T cell mediated immunity
  • positive regulation of mitotic nuclear division
  • memory
  • positive regulation of nitric oxide biosynthetic process
  • negative regulation of neural precursor cell proliferation
  • response to hypoxia
  • positive regulation of neutrophil chemotaxis
  • regulation of establishment of endothelial barrier
  • cellular response to drug
  • cellular response to antibiotic
  • pentacyclic triterpenoid metabolic process
  • stimulatory C-type lectin receptor signaling pathway
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • regulation of I-kappaB kinase/NF-kappaB signaling
  • response to dexamethasone
  • positive regulation of angiogenesis
  • cellular response to organic cyclic compound
  • polyketide metabolic process
  • wound healing
  • innate immune response
  • response to diuretic
  • positive regulation of interleukin-8 production
  • response to gamma radiation
  • positive regulation of astrocyte differentiation
  • regulation of insulin secretion
  • cellular response to fatty acid
  • positive regulation of apoptotic process
  • response to L-ascorbic acid
  • activation of MAPK activity
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of cell adhesion molecule production
  • neutrophil chemotaxis
  • negative regulation of lipid catabolic process
  • cellular response to methotrexate
  • chronic inflammatory response to antigenic stimulus
  • positive regulation of cytosolic calcium ion concentration
  • response to ozone
  • positive regulation of vascular endothelial growth factor production
  • cellular response to glucose stimulus
  • positive regulation of granulocyte macrophage colony-stimulating factor production
  • positive regulation of interleukin-6 production
  • positive regulation of JNK cascade
  • ectopic germ cell programmed cell death
  • positive regulation of protein phosphorylation
  • response to statin
  • positive regulation of T cell proliferation
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of histone acetylation
  • positive regulation of phagocytosis
  • positive regulation of vascular endothelial growth factor receptor signaling pathway
  • extrinsic apoptotic signaling pathway in absence of ligand
  • response to stilbenoid
  • positive regulation of gene expression
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • positive regulation of histone phosphorylation
  • purine nucleobase metabolic process
  • response to ATP
  • response to heat
  • fever generation
  • cellular response to mechanical stimulus
  • sequestering of triglyceride
  • response to ethanol
  • positive regulation of JUN kinase activity
  • signal transduction
  • positive regulation of immature T cell proliferation in thymus
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of fever generation
  • glycoprotein metabolic process
  • positive regulation of transcription, DNA-templated
  • smooth muscle adaptation
  • positive regulation of interferon-gamma production
  • negative regulation of glucose transport
  • positive regulation of lipid catabolic process
  • protein kinase B signaling
  • response to morphine
  • hyaluronan biosynthetic process
  • response to estradiol
  • positive regulation of interleukin-2 biosynthetic process
  • negative regulation of insulin receptor signaling pathway
  • positive regulation of monocyte chemotactic protein-1 production
  • cytokine-mediated signaling pathway
  • positive regulation of prostaglandin secretion
  • interleukin-1 beta production
  • response to peptide hormone
  • aging
  • positive regulation of calcidiol 1-monooxygenase activity
  • social behavior
Components
  • lysosome
  • cytosol
  • autophagosome
  • extracellular exosome
  • secretory granule
  • extracellular region
  • extracellular space
General FunctionProtein domain specific binding
Specific FunctionPotent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID307043
UniProtKB IDP01584
UniProtKB Entry NameIL1B_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010737|Interleukin-1 beta (IL1B)
ATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGAT
GACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGAC
CTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGC
TTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCC
TGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAA
GAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGA
TCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATAT
GAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATG
TCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAA
AAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGT
GTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATA
GAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTACATCAGCACC
TCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACT
GACTTCACCATGCAATTTGTGTCTTCCTAA
GenBank Gene IDK02770
GeneCard IDNot Available
GenAtlas IDIL1B
HGNC IDHGNC:5992
Chromosome Location2
Locus2q14
References
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