Interferon beta

NameInterferon beta
Synonyms
  • Fibroblast interferon
  • IFB
  • IFN-beta
  • IFNB
Gene NameIFNB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010650|Interferon beta
MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD
IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK
TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR
LTGYLRN
Number of residues187
Molecular Weight22293.68
Theoretical pI8.91
GO Classification
Functions
  • cytokine activity
  • chloramphenicol O-acetyltransferase activity
  • type I interferon receptor binding
Processes
  • type I interferon signaling pathway
  • blood coagulation
  • positive regulation of peptidyl-serine phosphorylation of STAT protein
  • adaptive immune response
  • regulation of MHC class I biosynthetic process
  • cellular response to interferon-beta
  • T cell activation involved in immune response
  • B cell differentiation
  • natural killer cell activation
  • humoral immune response
  • response to exogenous dsRNA
  • innate immune response
  • B cell activation involved in immune response
  • positive regulation of transcription from RNA polymerase II promoter
  • cellular response to exogenous dsRNA
  • cell surface receptor signaling pathway
  • cellular response to virus
  • defense response to bacterium
  • defense response to virus
  • B cell proliferation
  • natural killer cell activation involved in immune response
  • cytokine-mediated signaling pathway
  • negative regulation of T cell differentiation
  • cellular response to dexamethasone stimulus
  • negative regulation of T-helper 2 cell cytokine production
  • positive regulation of apoptotic signaling pathway
  • negative regulation of viral genome replication
  • regulation of type I interferon-mediated signaling pathway
  • response to virus
  • positive regulation of innate immune response
Components
  • extracellular region
  • extracellular space
General FunctionType i interferon receptor binding
Specific FunctionHas antiviral, antibacterial and anticancer activities.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID32638
UniProtKB IDP01574
UniProtKB Entry NameIFNB_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010651|Interferon beta (IFNB1)
ATGACCAACAAGTGTCTCCTCCAAATTGCTCTCCTGTTGTGCTTCTCCACTACAGCTCTT
TCCATGAGCTACAACTTGCTTGGATTCCTACAAAGAAGCAGCAATTTTCAGTGTCAGAAG
CTCCTGTGGCAATTGAATGGGAGGCTTGAATACTGCCTCAAGGACAGGATGAACTTTGAC
ATCCCTGAGGAGATTAAGCAGCTGCAGCAGTTCCAGAAGGAGGACGCCGCATTGACCATC
TATGAGATGCTCCAGAACATCTTTGCTATTTTCAGACAAGATTCATCTAGCACTGGCTGG
AATGAGACTATTGTTGAGAACCTCCTGGCTAATGTCTATCATCAGATAAACCATCTGAAG
ACAGTCCTGGAAGAAAAACTGGAGAAAGAAGATTTCACCAGGGGAAAACTCATGAGCAGT
CTGCACCTGAAAAGATATTATGGGAGGATTCTGCATTACCTGAAGGCCAAGGAGTACAGT
CACTGTGCCTGGACCATAGTCAGAGTGGAAATCCTAAGGAACTTTTACTTCATTAACAGA
CTTACAGGTTACCTCCGAAACTGA
GenBank Gene IDV00534
GeneCard IDNot Available
GenAtlas IDIFNB1
HGNC IDHGNC:5434
Chromosome Location9
Locus9p21
References
  1. Lawn RM, Adelman J, Franke AE, Houck CM, Gross M, Najarian R, Goeddel DV: Human fibroblast interferon gene lacks introns. Nucleic Acids Res. 1981 Mar 11;9(5):1045-52. 6164984
  2. Ohno S, Taniguchi T: Structure of a chromosomal gene for human interferon beta. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5305-9. 16593086
  3. Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M: The nucleotide sequence of human fibroblast interferon cDNA. Gene. 1980 Jun;10(1):11-5. 6157601
  4. Derynck R, Content J, DeClercq E, Volckaert G, Tavernier J, Devos R, Fiers W: Isolation and structure of a human fibroblast interferon gene. Nature. 1980 Jun 19;285(5766):542-7. 6157094
  5. Houghton M, Easton MA, Stewart AG, Smith JC, Doel SM, Catlin GH, Lewis HM, Patel TP, Emtage JS, Carey NH, Porter AG: The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase. Nucleic Acids Res. 1980 Jul 11;8(13):2885-94. 6159580
  6. Goeddel DV, Shepard HM, Yelverton E, Leung D, Crea R, Sloma A, Pestka S: Synthesis of human fibroblast interferon by E. coli. Nucleic Acids Res. 1980 Sep 25;8(18):4057-74. 6159584
  7. May LT, Sehgal PB: On the relationship between human interferon alpha 1 and beta 1 genes. J Interferon Res. 1985 Summer;5(3):521-6. 2414376
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  10. Houghton M, Stewart AG, Doel SM, Emtage JS, Eaton MA, Smith JC, Patel TP, Lewis HM, Porter AG, Birch JR, Cartwright T, Carey NH: The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. Nucleic Acids Res. 1980 May 10;8(9):1913-31. 6159597
  11. Wetzel R: Assignment of the disulphide bonds of leukocyte interferon. Nature. 1981 Feb 12;289(5798):606-7. 6162107
  12. Shepard HM, Leung D, Stebbing N, Goeddel DV: A single amino acid change in IFN-beta1 abolishes its antiviral activity. Nature. 1981 Dec 10;294(5841):563-5. 6171735
  13. Karpusas M, Nolte M, Benton CB, Meier W, Lipscomb WN, Goelz S: The crystal structure of human interferon beta at 2.2-A resolution. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11813-8. 9342320
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