Metalloproteinase inhibitor 1

NameMetalloproteinase inhibitor 1
Synonyms
  • CLGI
  • Collagenase inhibitor
  • EPA
  • Erythroid-potentiating activity
  • Fibroblast collagenase inhibitor
  • TIMP
  • TIMP-1
  • Tissue inhibitor of metalloproteinases 1
Gene NameTIMP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019751|Metalloproteinase inhibitor 1
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQR
YEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHIT
TCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEK
GFQSRHLACLPREPGLCTWQSLRSQIA
Number of residues207
Molecular Weight23170.64
Theoretical pINot Available
GO Classification
Functions
  • metal ion binding
  • metalloendopeptidase inhibitor activity
  • protease binding
  • cytokine activity
Processes
  • response to cytokine
  • response to hormone
  • platelet activation
  • cartilage development
  • negative regulation of membrane protein ectodomain proteolysis
  • regulation of integrin-mediated signaling pathway
  • negative regulation of metalloenzyme activity
  • extracellular matrix disassembly
  • negative regulation of trophoblast cell migration
  • extracellular matrix organization
  • response to peptide hormone
  • negative regulation of apoptotic process
  • platelet degranulation
  • positive regulation of cell proliferation
  • blood coagulation
  • negative regulation of endopeptidase activity
  • aging
Components
  • extracellular space
  • proteinaceous extracellular matrix
  • basement membrane
  • extracellular exosome
  • platelet alpha granule lumen
  • extracellular region
General FunctionProtease binding
Specific FunctionMetalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP01033
UniProtKB Entry NameTIMP1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0019752|Metalloproteinase inhibitor 1 (TIMP1)
ATGGCCCCCTTTGAGCCCCTGGCTTCTGGCATCCTGTTGTTGCTGTGGCTGATAGCCCCC
AGCAGGGCCTGCACCTGTGTCCCACCCCACCCACAGACGGCCTTCTGCAATTCCGACCTC
GTCATCAGGGCCAAGTTCGTGGGGACACCAGAAGTCAACCAGACCACCTTATACCAGCGT
TATGAGATCAAGATGACCAAGATGTATAAAGGGTTCCAAGCCTTAGGGGATGCCGCTGAC
ATCCGGTTCGTCTACACCCCCGCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCAC
AACCGCAGCGAGGAGTTTCTCATTGCTGGAAAACTGCAGGATGGACTCTTGCACATCACT
ACCTGCAGTTTTGTGGCTCCCTGGAACAGCCTGAGCTTAGCTCAGCGCCGGGGCTTCACC
AAGACCTACACTGTTGGCTGTGAGGAATGCACAGTGTTTCCCTGTTTATCCATCCCCTGC
AAACTGCAGAGTGGCACTCATTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAG
GGCTTCCAGTCCCGTCACCTTGCCTGCCTGCCTCGGGAGCCAGGGCTGTGCACCTGGCAG
TCCCTGCGGTCCCAGATAGCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11820
Chromosome LocationX
LocusNot Available
References
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