Adenosine deaminase

NameAdenosine deaminase
Synonyms
  • 3.5.4.4
  • ADA1
  • Adenosine aminohydrolase
Gene NameADA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020603|Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
Number of residues363
Molecular Weight40764.13
Theoretical pI5.8
GO Classification
Functions
  • adenosine deaminase activity
  • zinc ion binding
  • purine nucleoside binding
Processes
  • hypoxanthine salvage
  • dATP catabolic process
  • negative regulation of leukocyte migration
  • nucleobase-containing small molecule metabolic process
  • deoxyadenosine catabolic process
  • response to drug
  • negative regulation of mucus secretion
  • purine nucleobase metabolic process
  • germinal center B cell differentiation
  • response to morphine
  • purine-containing compound salvage
  • histamine secretion
  • lung alveolus development
  • negative regulation of inflammatory response
  • negative regulation of adenosine receptor signaling pathway
  • positive regulation of heart rate
  • positive regulation of B cell proliferation
  • embryonic digestive tract development
  • negative regulation of penile erection
  • regulation of cell-cell adhesion mediated by integrin
  • purine nucleotide salvage
  • positive regulation of germinal center formation
  • liver development
  • trophectodermal cell differentiation
  • small molecule metabolic process
  • Peyer's patch development
  • positive regulation of alpha-beta T cell differentiation
  • xanthine biosynthetic process
  • placenta development
  • negative regulation of mature B cell apoptotic process
  • T cell activation
  • positive regulation of T cell receptor signaling pathway
  • aging
  • negative regulation of thymocyte apoptotic process
  • positive regulation of T cell differentiation in thymus
  • response to vitamin E
  • positive regulation of calcium-mediated signaling
  • purine ribonucleoside monophosphate biosynthetic process
  • response to hydrogen peroxide
  • adenosine catabolic process
  • response to hypoxia
  • positive regulation of smooth muscle contraction
  • inosine biosynthetic process
  • negative regulation of circadian sleep/wake cycle, non-REM sleep
Components
  • membrane
  • plasma membrane
  • extracellular space
  • lysosome
  • dendrite cytoplasm
  • cell surface
  • neuronal cell body
  • cell junction
  • cytosol
  • external side of plasma membrane
  • cytoplasmic membrane-bounded vesicle lumen
  • cytoplasm
General FunctionZinc ion binding
Specific FunctionCatalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID28380
UniProtKB IDP00813
UniProtKB Entry NameADA_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0020604|Adenosine deaminase (ADA)
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTAGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA
GenBank Gene IDX02994
GeneCard IDNot Available
GenAtlas IDADA
HGNC IDHGNC:186
Chromosome Location20
Locus20q12-q13.11
References
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