Superoxide dismutase [Cu-Zn]

NameSuperoxide dismutase [Cu-Zn]
Synonyms
  • 1.15.1.1
  • hSod1
  • Superoxide dismutase 1
Gene NameSOD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021851|Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Number of residues154
Molecular Weight15935.685
Theoretical pI6.07
GO Classification
Functions
  • identical protein binding
  • zinc ion binding
  • chaperone binding
  • superoxide dismutase activity
  • copper ion binding
  • Rac GTPase binding
  • protein homodimerization activity
  • protein phosphatase 2B binding
Processes
  • regulation of T cell differentiation in thymus
  • positive regulation of apoptotic process
  • peripheral nervous system myelin maintenance
  • response to ethanol
  • regulation of blood pressure
  • auditory receptor cell stereocilium organization
  • cellular response to cadmium ion
  • negative regulation of neuron apoptotic process
  • response to antipsychotic drug
  • response to hydrogen peroxide
  • hydrogen peroxide biosynthetic process
  • transmission of nerve impulse
  • response to copper ion
  • myeloid cell homeostasis
  • sensory perception of sound
  • anterograde axon cargo transport
  • platelet activation
  • embryo implantation
  • neurofilament cytoskeleton organization
  • platelet degranulation
  • response to superoxide
  • glutathione metabolic process
  • retina homeostasis
  • superoxide metabolic process
  • regulation of protein kinase activity
  • response to heat
  • cellular iron ion homeostasis
  • locomotory behavior
  • response to carbon monoxide
  • regulation of GTPase activity
  • spermatogenesis
  • positive regulation of superoxide anion generation
  • response to amphetamine
  • superoxide anion generation
  • response to organic substance
  • response to reactive oxygen species
  • response to nutrient levels
  • heart contraction
  • reactive oxygen species metabolic process
  • ovarian follicle development
  • blood coagulation
  • cellular response to ATP
  • placenta development
  • cellular response to potassium ion
  • regulation of multicellular organism growth
  • cell aging
  • muscle cell cellular homeostasis
  • regulation of organ growth
  • positive regulation of catalytic activity
  • response to drug
  • response to axon injury
  • retrograde axon cargo transport
  • thymus development
  • response to antibiotic
  • regulation of mitochondrial membrane potential
  • negative regulation of cholesterol biosynthetic process
  • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  • activation of MAPK activity
  • positive regulation of cytokine production
  • removal of superoxide radicals
  • relaxation of vascular smooth muscle
Components
  • extracellular space
  • lysosome
  • cytoplasm
  • cytoplasmic vesicle
  • mitochondrion
  • mitochondrial intermembrane space
  • protein complex
  • dense core granule
  • peroxisome
  • extracellular matrix
  • dendrite cytoplasm
  • extracellular region
  • cytosol
  • nucleus
  • neuronal cell body
  • extracellular exosome
  • myelin sheath
  • mitochondrial matrix
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionDestroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP00441
UniProtKB Entry NameSODC_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021852|Superoxide dismutase [Cu-Zn] (SOD1)
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
GenBank Gene IDL44139
GeneCard IDNot Available
GenAtlas IDSOD1
HGNC IDHGNC:11179
Chromosome Location21
LocusNot Available
References
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