Superoxide dismutase [Cu-Zn]

NameSuperoxide dismutase [Cu-Zn]
Synonyms
  • 1.15.1.1
  • hSod1
  • Superoxide dismutase 1
Gene NameSOD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021851|Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Number of residues154
Molecular Weight15935.685
Theoretical pI6.07
GO Classification
Functions
  • identical protein binding
  • zinc ion binding
  • superoxide dismutase activity
  • chaperone binding
  • copper ion binding
  • Rac GTPase binding
  • protein homodimerization activity
  • protein phosphatase 2B binding
Processes
  • peripheral nervous system myelin maintenance
  • regulation of T cell differentiation in thymus
  • regulation of blood pressure
  • negative regulation of neuron apoptotic process
  • cellular response to cadmium ion
  • response to hydrogen peroxide
  • transmission of nerve impulse
  • auditory receptor cell stereocilium organization
  • response to copper ion
  • hydrogen peroxide biosynthetic process
  • sensory perception of sound
  • platelet activation
  • response to antipsychotic drug
  • myeloid cell homeostasis
  • embryo implantation
  • anterograde axon cargo transport
  • platelet degranulation
  • neurofilament cytoskeleton organization
  • glutathione metabolic process
  • response to superoxide
  • regulation of protein kinase activity
  • response to heat
  • superoxide metabolic process
  • locomotory behavior
  • retina homeostasis
  • regulation of GTPase activity
  • spermatogenesis
  • response to amphetamine
  • cellular iron ion homeostasis
  • positive regulation of superoxide anion generation
  • response to organic substance
  • response to carbon monoxide
  • response to nutrient levels
  • response to reactive oxygen species
  • reactive oxygen species metabolic process
  • ovarian follicle development
  • blood coagulation
  • superoxide anion generation
  • cellular response to ATP
  • placenta development
  • heart contraction
  • regulation of multicellular organism growth
  • cellular response to potassium ion
  • muscle cell cellular homeostasis
  • response to drug
  • cell aging
  • response to axon injury
  • positive regulation of catalytic activity
  • response to antibiotic
  • regulation of organ growth
  • regulation of mitochondrial membrane potential
  • thymus development
  • retrograde axon cargo transport
  • activation of MAPK activity
  • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  • removal of superoxide radicals
  • negative regulation of cholesterol biosynthetic process
  • relaxation of vascular smooth muscle
  • positive regulation of cytokine production
  • positive regulation of apoptotic process
  • response to ethanol
Components
  • lysosome
  • cytoplasm
  • cytoplasmic vesicle
  • mitochondrion
  • mitochondrial intermembrane space
  • protein complex
  • dense core granule
  • peroxisome
  • extracellular matrix
  • dendrite cytoplasm
  • extracellular region
  • cytosol
  • nucleus
  • neuronal cell body
  • extracellular exosome
  • myelin sheath
  • mitochondrial matrix
  • nucleoplasm
  • extracellular space
General FunctionZinc ion binding
Specific FunctionDestroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP00441
UniProtKB Entry NameSODC_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021852|Superoxide dismutase [Cu-Zn] (SOD1)
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
GenBank Gene IDL44139
GeneCard IDNot Available
GenAtlas IDSOD1
HGNC IDHGNC:11179
Chromosome Location21
LocusNot Available
References
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