Cytochrome b5

NameCytochrome b5
Synonyms
  • CYB5
  • MCB5
  • Microsomal cytochrome b5 type A
Gene NameCYB5A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002333|Cytochrome b5
MAEQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDAT
ENFEDVGHSTDAREMSKTFIIGELHPDDRPKLNKPPETLITTIDSSSSWWTNWVIPAISA
VAVALMYRLYMAED
Number of residues134
Molecular Weight15329.985
Theoretical pI4.61
GO Classification
Functions
  • heme binding
  • aldo-keto reductase (NADP) activity
  • cytochrome-c oxidase activity
  • metal ion binding
  • enzyme binding
Processes
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • L-ascorbic acid metabolic process
  • response to cadmium ion
  • hydrogen ion transmembrane transport
  • small molecule metabolic process
Components
  • intracellular membrane-bounded organelle
  • cytoplasm
  • membrane
  • endoplasmic reticulum membrane
  • mitochondrial outer membrane
  • integral component of membrane
  • extracellular exosome
General FunctionMetal ion binding
Specific FunctionCytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
Pfam Domain Function
Transmembrane Regions109-131
GenBank Protein ID181227
UniProtKB IDP00167
UniProtKB Entry NameCYB5_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0010818|Cytochrome b5 (CYB5A)
ATGGCAGAGCAGTCGGACGAGGCCGTGAAGTACTACACCCTAGAGGAGATTCAGAAGCAC
AACCACAGCAAGAGCACCTGGCTGATCCTGCACCACAAGGTGTACGATTTGACCAAATTT
CTGGAAGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACT
GAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATC
ATTGGGGAGCTCCATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGG
ACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATAC
ATGGCAGAGGACTGA
GenBank Gene IDM22865
GeneCard IDNot Available
GenAtlas IDCYB5A
HGNC IDHGNC:2570
Chromosome Location18
Locus18q23
References
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  2. Giordano SJ, Steggles AW: The human liver and reticulocyte cytochrome b5 mRNAs are products from a single gene. Biochem Biophys Res Commun. 1991 Jul 15;178(1):38-44. 1712589
  3. Li XR, Giordano SJ, Yoo M, Steggles AW: The isolation and characterization of the human cytochrome b5 gene. Biochem Biophys Res Commun. 1995 Apr 26;209(3):894-900. 7733981
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