Adenylate cyclase type 5

NameAdenylate cyclase type 5
Synonyms
  • 4.6.1.1
  • AC5
  • Adenylate cyclase type V
  • Adenylyl cyclase 5
  • ATP pyrophosphate-lyase 5
Gene NameADCY5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007170|Adenylate cyclase type 5
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
S
Number of residues1261
Molecular Weight138906.37
Theoretical pI7.25
GO Classification
Functions
  • metal ion binding
  • protein heterodimerization activity
  • ATP binding
  • adenylate cyclase binding
  • adenylate cyclase activity
Processes
  • activation of phospholipase C activity
  • cellular response to glucagon stimulus
  • renal water homeostasis
  • small molecule metabolic process
  • water transport
  • neuromuscular process controlling balance
  • epidermal growth factor receptor signaling pathway
  • innate immune response
  • activation of protein kinase A activity
  • positive regulation of cytosolic calcium ion concentration
  • cAMP biosynthetic process
  • transmembrane transport
  • cAMP-mediated signaling
  • fibroblast growth factor receptor signaling pathway
  • cellular response to forskolin
  • neurotrophin TRK receptor signaling pathway
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway
  • energy reserve metabolic process
  • signal transduction
  • regulation of insulin secretion involved in cellular response to glucose stimulus
  • locomotory behavior
  • adenosine receptor signaling pathway
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • synaptic transmission
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
Components
  • integral component of membrane
  • cytosol
  • primary cilium
  • intracellular
  • plasma membrane
General FunctionProtein heterodimerization activity
Specific FunctionCatalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
Pfam Domain Function
Transmembrane Regions196-216 242-262 268-288 299-319 325-345 374-394 770-790 792-812 836-856 910-930 935-955 984-1004
GenBank Protein ID22212711
UniProtKB IDO95622
UniProtKB Entry NameADCY5_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0012605|Adenylate cyclase type 5 (ADCY5)
ATGAAGTCTCAGAAAGAGGGCTGTTGCAGCAGAGGTGACCTGTCCATTCAGACAGGTCCT
GGAGGAGAATGGGCCCCACGGAGGCTTGTCTCCAATGTTCTCATTTTCTCCTGCACCAAC
ATCGTGGGTGTCTGCACCCACTATCCGGCTGAGGTCTCCCAGAGACAGGCTTTCCAGGAG
ACCCGAGAGTGCATCCAGGCGCGGCTCCACTCGCAGCGGGAGAACCAGCAGCAGGAACGG
CTCCTGCTGTCTGTCCTTCCCCGTCATGTTGCCATGGAGATGAAAGCAGACATCAACGCC
AAGCAGGAGGATATGATGTTCCATAAGATTTACATCCAGAAACATGACAACGTGAGCATC
CTGTTTGCTGACATCGAGGGCTTCACCAGCCTGGCGTCCCAGTGCACTGCACAGGAACTG
GTCATGACCCTCAACGAGCTCTTCGCCCGCTTTGACAAGCTGGCCGCAGAGAATCACTGT
TTACGTATTAAGATCCTTGGGGATTGTTATTACTGCGTCTCGGGGCTGCCTGAAGCAAGG
GCTGACCACGCCCACTGCTGTGTGGAGATGGGCATGGACATGATCGAGGCCATCTCGTTG
GTCCGGGAGGTGACAGGGGTGAACGTGAACATGCGTGTGGGAATTCACAGCGGGCGAGTA
CACTGCGGTGTCCTTGGTCTCAGGAAGTGGCAGTTCGACGTCTGGTCTAACGATGTCACG
CTAGCCAACCACATGGAGGCTGGCGGCAAGGCAGGACGCATCCACATCACCAAGGCTACA
CTCAACTACCTGAATGGGGACTACGAGGTGGAGCCAGGCTGTGGGGGCGAGCGCAACGCC
TACCTCAAGGAGCACAGTATCGAGACCTTCCTCATCCTGCGCTGCACCCAGAAGCGGAAA
GAAGAGAAGGCCATGATCGCCAAGATGAACCGCCAGAGAACCAACTCCATCGGGCACAAC
CCACCACACTGGGGGGCTGAGCGCCCCTTCTACAACCACCTGGGTGGCAACCAGGTGTCC
AAGGAGATGAAGCGGATGGGCTTTGAAGACCCCAAGGACAAGAACGCCCAGGAGAGTGCG
AACCCTGAGGATGAAGTGGATGAGTTTCTGGGCCGTGCCATTGACGCCAGGAGCATTGAT
AGGCTTCGGTCTGAGCACGTCCGCAAGTTCCTCCTGACCTTCAGGGAGCCTGACTTAGAG
AAGAAGTACTCCAAGCAGGTAGACGACCGATTTGGTGCCTATGTGGCGTGTGCCTCGCTC
GTCTTCCTCTTCATCTGCTTTGTCCAGATCACCATCGTGCCCCACTCCATATTCATGCTC
AGCTTCTACCTGACCTGTTCCCTGCTGCTGACCTTGGTGGTGTTTGTGTCTGTGATCTAC
TCCTGCGTAAAGCTCTTCCCCTCCCCACTGCAGACCCTCTCCAGGAAGATCGTGCGGTCC
AAGATGAACAGCACCCTGGTTGGGGTGTTCACCATCACCCTGGTGTTCCTGGCGGCTTTT
GTCAACATGTTCACGTGCAACTCCAGGGACCTGCTGGGCTGCTTGGCACAGGAGCACAAC
ATCAGCGCGAGCCAGGTCAACGCGTGTCACGTGGCGGAGTCGGCCGTCAACTACAGCCTG
GGCGATGAGCAGGGCTTCTGTGGCAGCCCCTGGCCCAACTGCAACTTCCCCGAGTACTTC
ACCTACAGCGTGCTGCTCAGCCTGCTGGCCTGCTCCGTGTTCCTGCAGATCAGCTGCATC
GGGAAGCTGGTGCTCATGCTGGCCATCGAGCTCATCTACGTGCTCATCGTGGAGGTGCCA
GGTGTCACGCTCTTCGACAACGCCGACCTGCTGGTCACCGCCAACGCCATAGACTTCTTC
AACAACGGGACCTCCCAGTGCCCTGAGCATGCAACCAAGGTGGCATTGAAGGTGGTGACG
CCCATCATCATCTCAGTCTTTGTGCTGGCCCTGTACCTGCACGCCCAGCAGGTGGAGTCC
ACTGCCCGCCTCGACTTCCTCTGGAAACTGCAGGCCACAGAGGAGAAAGAGGAGATGGAG
GAGCTGCAGGCCTACAACCGGCGGCTGCTGCACAACATCCTGCCCAAGGACGTGGCCGCT
CACTTCCTGGCCCGCGAGCGGCGCAATGATGAGCTCTACTATCAGTCCTGTGAGTGTGTG
GCGGTCATGTTCGCCTCCATCGCCAACTTCTCCGAGTTCTACGTTGAGCTGGAGGCCAAC
AACGAGGGTGTCGAGTGCCTGCGGCTACTCAATGAGATCATCGCTGACTTTGATGAGATC
ATCAGCGAGGATCGGTTCCGGCAGCTGGAGAAGATCAAGACCATCGGCAGCACCTACATG
GCTGCCTCCGGCCTCAACGACTCTACCTACGACAAGGTGGGCAAGACCCACATCAAGGCA
CTGGCCGACTTTGCCATGAAGCTGATGGACCAGATGAAGTACATCAATGAGCACTCCTTC
AACAACTTCCAGATGAAGATCGGGCTCAACATCGGCCCCGTGGTGGCCGGGGTGATAGGG
GCACGAAAGCCTCAGTACGACATCTGGGGCAATACCGTGAACGTGGCCAGCCGCATGGAC
AGCACCGGTGTACCCGACCGCATCCAGGTCACCACAGACATGTACCAGGTGCTGGCTGCC
AACACGTACCAGCTGGAGTGCCGGGGCGTGGTCAAGGTCAAGGGCAAAGGCGAGATGATG
ACCTACTTCCTCAATGGAGGGCCCCCGCTCAGTTAG
GenBank Gene IDAF497517
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:236
Chromosome Location3
Locus3q13.2-q21
References
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